Tags

Type your tag names separated by a space and hit enter

Early life insult from cigarette smoke may be predictive of chronic diseases later in life.

Abstract

Evidence is rapidly accumulating that links cigarette smoke (CS) exposure in utero with the development of a variety of disease pathologies in the older offspring including, type 2 diabetes, obesity, certain childhood cancers and respiratory disorders. The role that the fetal environment plays in these late-onset outcomes and the underlying cellular/molecular mechanisms by which these CS-induced effects may occur are currently unknown. Although we are becoming more aware of the fact that prenatal insult can underlie childhood/adult diseases, critical knowledge gaps still exist including gene-environment interactions, and how a CS-induced imbalance in immune dynamics (i.e. TH1/TH2) might affect asthma development and/or exacerbation later in life. In this mini-review we introduce the concept of sexual dimorphism in CS-induced late-onset disease outcomes, as well as explore the mechanisms by which CS exposure in utero can lead to cardiovascular, cancer and respiratory abnormalities in the exposed offspring. By addressing such questions using animal models, appropriate intervention strategies can be developed that will help to protect children's health and their long-term quality of life.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Nelson Institute of Environmental Health, NYU School of Medicine, Tuxedo, NY 10987, USA.

    , , ,

    Source

    MeSH

    Animals
    Cardiovascular Diseases
    Chronic Disease
    Female
    Genetic Predisposition to Disease
    Humans
    Models, Animal
    Neoplasms
    Pregnancy
    Prenatal Exposure Delayed Effects
    Respiratory Tract Diseases
    Risk Assessment
    Risk Factors
    Sex Factors
    Smoking
    Time Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19604068

    Citation

    Doherty, S P., et al. "Early Life Insult From Cigarette Smoke May Be Predictive of Chronic Diseases Later in Life." Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, vol. 14 Suppl 1, 2009, pp. 97-101.
    Doherty SP, Grabowski J, Hoffman C, et al. Early life insult from cigarette smoke may be predictive of chronic diseases later in life. Biomarkers. 2009;14 Suppl 1:97-101.
    Doherty, S. P., Grabowski, J., Hoffman, C., Ng, S. P., & Zelikoff, J. T. (2009). Early life insult from cigarette smoke may be predictive of chronic diseases later in life. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 14 Suppl 1, pp. 97-101. doi:10.1080/13547500902965898.
    Doherty SP, et al. Early Life Insult From Cigarette Smoke May Be Predictive of Chronic Diseases Later in Life. Biomarkers. 2009;14 Suppl 1:97-101. PubMed PMID: 19604068.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Early life insult from cigarette smoke may be predictive of chronic diseases later in life. AU - Doherty,S P, AU - Grabowski,J, AU - Hoffman,C, AU - Ng,S P, AU - Zelikoff,J T, PY - 2009/7/17/entrez PY - 2009/10/22/pubmed PY - 2010/1/29/medline SP - 97 EP - 101 JF - Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals JO - Biomarkers VL - 14 Suppl 1 N2 - Evidence is rapidly accumulating that links cigarette smoke (CS) exposure in utero with the development of a variety of disease pathologies in the older offspring including, type 2 diabetes, obesity, certain childhood cancers and respiratory disorders. The role that the fetal environment plays in these late-onset outcomes and the underlying cellular/molecular mechanisms by which these CS-induced effects may occur are currently unknown. Although we are becoming more aware of the fact that prenatal insult can underlie childhood/adult diseases, critical knowledge gaps still exist including gene-environment interactions, and how a CS-induced imbalance in immune dynamics (i.e. TH1/TH2) might affect asthma development and/or exacerbation later in life. In this mini-review we introduce the concept of sexual dimorphism in CS-induced late-onset disease outcomes, as well as explore the mechanisms by which CS exposure in utero can lead to cardiovascular, cancer and respiratory abnormalities in the exposed offspring. By addressing such questions using animal models, appropriate intervention strategies can be developed that will help to protect children's health and their long-term quality of life. SN - 1366-5804 UR - https://www.unboundmedicine.com/medline/citation/19604068/Early_life_insult_from_cigarette_smoke_may_be_predictive_of_chronic_diseases_later_in_life_ L2 - http://www.tandfonline.com/doi/full/10.1080/13547500902965898 DB - PRIME DP - Unbound Medicine ER -