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Is type 2 diabetes mellitus a cause of severe erectile dysfunction in patients with metabolic syndrome?

Abstract

OBJECTIVES

To determine the effect of type 2 diabetes mellitus (T2DM) as a major risk factor for severe erectile dysfunction (ED) in patients with metabolic syndrome (MS).

METHODS

The study included 93 patients aged 30-70 years who had MS and ED. MS patients were divided into 2 groups: 37 patients with neither T2DM nor abnormal fasting glucose level (group 1) and 56 patients with T2DM (group 2). The severity of ED was determined according to the first 5-question version of the International Index of Erectile Function (IIEF-5). The MS was defined according to the 2005 International Diabetes Federation consensus definition. Logistic regression analysis, t test, and chi(2) tests were used to investigate the impact of T2DM on ED severity.

RESULTS

The mean age of the patients was 55.5 years (P = .313). Eleven patients in group 1 (29.7%) and 42 patients in group 2 (75%) had severe ED (IIEF-5 score <or=7; P < .001). Abnormal blood pressure (BP), serum high-density lipoprotein (HDL), and serum triglyceride (TG) ratios were found to be 48.6%, 75.7%, and 86.5% in group 1 and 51.8%, 53.6% and 73.2% in group 2, respectively (P(BP) = .933; P(HDL) = .053; P(TG) = .205). The IIEF-5 scores were higher in group 1 patients than in group 2 patients (12.6 vs. 7.5; P(IIEF-5) < .001). Presence of T2DM was significantly associated with severe ED, and the relative risk was as high as 7.1 (P(T2DM) < .001).

CONCLUSIONS

In our study, the presence of T2DM was strongly associated with severe ED in patients with MS. We believe that components of MS should be taken into consideration in the diagnosis and treatment of ED.

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  • Authors+Show Affiliations

    ,

    Third Department of Urology, Ankara Numune Research and Training Hospital, Ministry of Health, Ankara, Turkey. anaunaki3600@yahoo.com

    , , , ,

    Source

    Urology 74:3 2009 Sep pg 561-4

    MeSH

    Adult
    Aged
    Diabetes Mellitus, Type 2
    Erectile Dysfunction
    Humans
    Male
    Metabolic Syndrome
    Middle Aged
    Risk Factors
    Severity of Illness Index

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19604566

    Citation

    Aslan, Yilmaz, et al. "Is Type 2 Diabetes Mellitus a Cause of Severe Erectile Dysfunction in Patients With Metabolic Syndrome?" Urology, vol. 74, no. 3, 2009, pp. 561-4.
    Aslan Y, Sezgin T, Tuncel A, et al. Is type 2 diabetes mellitus a cause of severe erectile dysfunction in patients with metabolic syndrome? Urology. 2009;74(3):561-4.
    Aslan, Y., Sezgin, T., Tuncel, A., Tekdogan, U. Y., Guler, S., & Atan, A. (2009). Is type 2 diabetes mellitus a cause of severe erectile dysfunction in patients with metabolic syndrome? Urology, 74(3), pp. 561-4. doi:10.1016/j.urology.2009.02.073.
    Aslan Y, et al. Is Type 2 Diabetes Mellitus a Cause of Severe Erectile Dysfunction in Patients With Metabolic Syndrome. Urology. 2009;74(3):561-4. PubMed PMID: 19604566.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Is type 2 diabetes mellitus a cause of severe erectile dysfunction in patients with metabolic syndrome? AU - Aslan,Yilmaz, AU - Sezgin,Tezcan, AU - Tuncel,Altug, AU - Tekdogan,Umit Y, AU - Guler,Serdar, AU - Atan,Ali, Y1 - 2009/07/14/ PY - 2008/11/30/received PY - 2009/01/30/revised PY - 2009/02/04/accepted PY - 2009/7/17/entrez PY - 2009/7/17/pubmed PY - 2009/9/17/medline SP - 561 EP - 4 JF - Urology JO - Urology VL - 74 IS - 3 N2 - OBJECTIVES: To determine the effect of type 2 diabetes mellitus (T2DM) as a major risk factor for severe erectile dysfunction (ED) in patients with metabolic syndrome (MS). METHODS: The study included 93 patients aged 30-70 years who had MS and ED. MS patients were divided into 2 groups: 37 patients with neither T2DM nor abnormal fasting glucose level (group 1) and 56 patients with T2DM (group 2). The severity of ED was determined according to the first 5-question version of the International Index of Erectile Function (IIEF-5). The MS was defined according to the 2005 International Diabetes Federation consensus definition. Logistic regression analysis, t test, and chi(2) tests were used to investigate the impact of T2DM on ED severity. RESULTS: The mean age of the patients was 55.5 years (P = .313). Eleven patients in group 1 (29.7%) and 42 patients in group 2 (75%) had severe ED (IIEF-5 score <or=7; P < .001). Abnormal blood pressure (BP), serum high-density lipoprotein (HDL), and serum triglyceride (TG) ratios were found to be 48.6%, 75.7%, and 86.5% in group 1 and 51.8%, 53.6% and 73.2% in group 2, respectively (P(BP) = .933; P(HDL) = .053; P(TG) = .205). The IIEF-5 scores were higher in group 1 patients than in group 2 patients (12.6 vs. 7.5; P(IIEF-5) < .001). Presence of T2DM was significantly associated with severe ED, and the relative risk was as high as 7.1 (P(T2DM) < .001). CONCLUSIONS: In our study, the presence of T2DM was strongly associated with severe ED in patients with MS. We believe that components of MS should be taken into consideration in the diagnosis and treatment of ED. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/19604566/Is_type_2_diabetes_mellitus_a_cause_of_severe_erectile_dysfunction_in_patients_with_metabolic_syndrome L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(09)00398-7 DB - PRIME DP - Unbound Medicine ER -