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Soy protein reduces serum LDL cholesterol and the LDL cholesterol:HDL cholesterol and apolipoprotein B:apolipoprotein A-I ratios in adults with type 2 diabetes.
J Nutr. 2009 Sep; 139(9):1700-6.JN

Abstract

Type 2 diabetes is highly prevalent in North America and is associated with increased risk of cardiovascular disease (CVD). Evidence supports a role for soy protein in the reduction of serum lipids related to CVD risk; however, few studies have focused on adults with type 2 diabetes who are not on lipid-lowering medications and/or do not have diabetic complications. The purpose of this study was to determine the effect of soy protein isolate (SPI) consumption on serum lipids in adults with diet-controlled type 2 diabetes. Using a double-blind, randomized, crossover, placebo-controlled intervention study design, adults with diet-controlled type 2 diabetes (n = 29) consumed SPI (80 mg/d aglycone isoflavones) or milk protein isolate (MPI) for 57 d each separated by a 28-d washout period. Twenty-four-hour urine samples were collected on d 54-56 of each treatment for analysis of isoflavones and blood was collected on d 1 and 57 of each treatment and analyzed for serum lipids and apolipoproteins. SPI consumption increased urinary isoflavones compared with MPI. SPI consumption reduced serum LDL cholesterol (P = 0.04), LDL cholesterol:HDL cholesterol (P = 0.02), and apolipoprotein B:apolipoprotein A-I (P = 0.05) compared with MPI. SPI did not affect serum total cholesterol, HDL cholesterol, triacylglycerol, apolipoprotein B, or apolipoprotein A-I. These data demonstrate that consumption of soy protein can modulate some serum lipids in a direction beneficial for CVD risk in adults with type 2 diabetes.

Authors+Show Affiliations

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19605528

Citation

Pipe, Elizabeth A., et al. "Soy Protein Reduces Serum LDL Cholesterol and the LDL cholesterol:HDL Cholesterol and Apolipoprotein B:apolipoprotein A-I Ratios in Adults With Type 2 Diabetes." The Journal of Nutrition, vol. 139, no. 9, 2009, pp. 1700-6.
Pipe EA, Gobert CP, Capes SE, et al. Soy protein reduces serum LDL cholesterol and the LDL cholesterol:HDL cholesterol and apolipoprotein B:apolipoprotein A-I ratios in adults with type 2 diabetes. J Nutr. 2009;139(9):1700-6.
Pipe, E. A., Gobert, C. P., Capes, S. E., Darlington, G. A., Lampe, J. W., & Duncan, A. M. (2009). Soy protein reduces serum LDL cholesterol and the LDL cholesterol:HDL cholesterol and apolipoprotein B:apolipoprotein A-I ratios in adults with type 2 diabetes. The Journal of Nutrition, 139(9), 1700-6. https://doi.org/10.3945/jn.109.109595
Pipe EA, et al. Soy Protein Reduces Serum LDL Cholesterol and the LDL cholesterol:HDL Cholesterol and Apolipoprotein B:apolipoprotein A-I Ratios in Adults With Type 2 Diabetes. J Nutr. 2009;139(9):1700-6. PubMed PMID: 19605528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy protein reduces serum LDL cholesterol and the LDL cholesterol:HDL cholesterol and apolipoprotein B:apolipoprotein A-I ratios in adults with type 2 diabetes. AU - Pipe,Elizabeth A, AU - Gobert,Colleen P, AU - Capes,Sarah E, AU - Darlington,Gerarda A, AU - Lampe,Johanna W, AU - Duncan,Alison M, Y1 - 2009/07/15/ PY - 2009/7/17/entrez PY - 2009/7/17/pubmed PY - 2009/9/18/medline SP - 1700 EP - 6 JF - The Journal of nutrition JO - J Nutr VL - 139 IS - 9 N2 - Type 2 diabetes is highly prevalent in North America and is associated with increased risk of cardiovascular disease (CVD). Evidence supports a role for soy protein in the reduction of serum lipids related to CVD risk; however, few studies have focused on adults with type 2 diabetes who are not on lipid-lowering medications and/or do not have diabetic complications. The purpose of this study was to determine the effect of soy protein isolate (SPI) consumption on serum lipids in adults with diet-controlled type 2 diabetes. Using a double-blind, randomized, crossover, placebo-controlled intervention study design, adults with diet-controlled type 2 diabetes (n = 29) consumed SPI (80 mg/d aglycone isoflavones) or milk protein isolate (MPI) for 57 d each separated by a 28-d washout period. Twenty-four-hour urine samples were collected on d 54-56 of each treatment for analysis of isoflavones and blood was collected on d 1 and 57 of each treatment and analyzed for serum lipids and apolipoproteins. SPI consumption increased urinary isoflavones compared with MPI. SPI consumption reduced serum LDL cholesterol (P = 0.04), LDL cholesterol:HDL cholesterol (P = 0.02), and apolipoprotein B:apolipoprotein A-I (P = 0.05) compared with MPI. SPI did not affect serum total cholesterol, HDL cholesterol, triacylglycerol, apolipoprotein B, or apolipoprotein A-I. These data demonstrate that consumption of soy protein can modulate some serum lipids in a direction beneficial for CVD risk in adults with type 2 diabetes. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/19605528/Soy_protein_reduces_serum_LDL_cholesterol_and_the_LDL_cholesterol:HDL_cholesterol_and_apolipoprotein_B:apolipoprotein_A_I_ratios_in_adults_with_type_2_diabetes_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.109.109595 DB - PRIME DP - Unbound Medicine ER -