Tags

Type your tag names separated by a space and hit enter

The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction.

Abstract

Epidemiological studies demonstrated a relationship between low birth weight mainly caused by intrauterine growth restriction (IUGR) and adult metabolic disorders. The concept of metabolic programming centers on the idea that nutritional and hormonal status during the key period of development determines the long-term control of energy balance by programming future feeding behavior and energy expenditure. The present study examined the consequence of early or late "catch-up growth" after IUGR on feeding behavior and metabolic cues of male offspring of rat dams exposed to protein restriction during gestation and/or lactation. Our results suggest that early catch-up growth may be favorable for fasting metabolic parameters at weaning, as no differences were observed on plasma leptin, triglyceride, glucose, and insulin levels compared with controls. In contrast, if pups remained malnourished until weaning, low insulin concentration was detected and was accompanied by hyperphagia associated with a large increase in hypothalamic NPY and AgRP mRNA expression. At adult age, on a regular chow diet, only the meal structure was modified by fetal programming. The two IUGR groups demonstrated a reduced meal duration that enhanced the speed of food ingestion and consequently increased the rest period associated to the satiety state without changes in the hypothalamic expression of appetite neuropeptides. Our findings demonstrate that in IUGR, regardless of postnatal growth magnitude, metabolic programming occurred in utero and was responsible for both feeding behavior alteration and postprandial higher insulin level in adults. Additionally, catch-up growth immediately after early malnutrition could be a key point for the programming of postprandial hyperleptinemia.

Authors+Show Affiliations

Institut National de la Recherche Agronomique, UMR 1280 Physiologie des Adaptations Nutritionnelles, Université de Nantes, Nantes, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19605764

Citation

Coupé, Bérengère, et al. "The Timing of "catch-up Growth" Affects Metabolism and Appetite Regulation in Male Rats Born With Intrauterine Growth Restriction." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 297, no. 3, 2009, pp. R813-24.
Coupé B, Grit I, Darmaun D, et al. The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2009;297(3):R813-24.
Coupé, B., Grit, I., Darmaun, D., & Parnet, P. (2009). The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 297(3), pp. R813-24. doi:10.1152/ajpregu.00201.2009.
Coupé B, et al. The Timing of "catch-up Growth" Affects Metabolism and Appetite Regulation in Male Rats Born With Intrauterine Growth Restriction. Am J Physiol Regul Integr Comp Physiol. 2009;297(3):R813-24. PubMed PMID: 19605764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction. AU - Coupé,Bérengère, AU - Grit,Isabelle, AU - Darmaun,Dominique, AU - Parnet,Patricia, Y1 - 2009/07/15/ PY - 2009/7/17/entrez PY - 2009/7/17/pubmed PY - 2009/9/11/medline SP - R813 EP - 24 JF - American journal of physiology. Regulatory, integrative and comparative physiology JO - Am. J. Physiol. Regul. Integr. Comp. Physiol. VL - 297 IS - 3 N2 - Epidemiological studies demonstrated a relationship between low birth weight mainly caused by intrauterine growth restriction (IUGR) and adult metabolic disorders. The concept of metabolic programming centers on the idea that nutritional and hormonal status during the key period of development determines the long-term control of energy balance by programming future feeding behavior and energy expenditure. The present study examined the consequence of early or late "catch-up growth" after IUGR on feeding behavior and metabolic cues of male offspring of rat dams exposed to protein restriction during gestation and/or lactation. Our results suggest that early catch-up growth may be favorable for fasting metabolic parameters at weaning, as no differences were observed on plasma leptin, triglyceride, glucose, and insulin levels compared with controls. In contrast, if pups remained malnourished until weaning, low insulin concentration was detected and was accompanied by hyperphagia associated with a large increase in hypothalamic NPY and AgRP mRNA expression. At adult age, on a regular chow diet, only the meal structure was modified by fetal programming. The two IUGR groups demonstrated a reduced meal duration that enhanced the speed of food ingestion and consequently increased the rest period associated to the satiety state without changes in the hypothalamic expression of appetite neuropeptides. Our findings demonstrate that in IUGR, regardless of postnatal growth magnitude, metabolic programming occurred in utero and was responsible for both feeding behavior alteration and postprandial higher insulin level in adults. Additionally, catch-up growth immediately after early malnutrition could be a key point for the programming of postprandial hyperleptinemia. SN - 1522-1490 UR - https://www.unboundmedicine.com/medline/citation/19605764/The_timing_of_"catch_up_growth"_affects_metabolism_and_appetite_regulation_in_male_rats_born_with_intrauterine_growth_restriction_ L2 - http://www.physiology.org/doi/full/10.1152/ajpregu.00201.2009?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -