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Fish oil lipid emulsions and immune response: what clinicians need to know.
Nutr Clin Pract 2009 Aug-Sep; 24(4):487-99NC

Abstract

Current evidence indicates that omega-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid and docosahexaenoic acid found in fish oil, can prevent the development of inflammatory diseases by affecting different steps of the immune response. The capacity of omega-3 PUFAs to modulate synthesis of eicosanoids, activity of nuclear receptor and nuclear transcription factors, and production of resolvins may also mitigate inflammatory processes already present. Parenteral infusion of omega-3 PUFAs is advantageous, particularly in severely ill patients, because the fatty acids are rapidly incorporated by cells. In addition, when fatty acids are given parenterally, there are no losses from digestion and absorption as there are with enteral infusion. Recently, lipid emulsions enriched with omega-3 fish oil have been introduced as a component of parenteral nutrition. Currently, there is one lipid emulsion that contains only fish oil; it is infused together with conventionally used lipid emulsions. Other commercially available lipid emulsions contain fish oil in a fat mixture; one contains 10% fish oil and another 15% fish oil. Relevant experimental and clinical data from studies evaluating fish oil lipid emulsions are discussed in the present review. Administration of fish oil lipid emulsion, when compared with soybean oil lipid emulsion (rich in omega-6 PUFA), decreases the length of hospital and intensive care unit stay in surgical patients.

Authors+Show Affiliations

Laboratory of Nutrition and Metabolic Surgery of the Digestive System, Gastroenterology Department, University of São Paulo Medical School, Brazil. metanutri@terra.com.brNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19605803

Citation

Waitzberg, Dan Linetzky, and Raquel Susana Torrinhas. "Fish Oil Lipid Emulsions and Immune Response: what Clinicians Need to Know." Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, vol. 24, no. 4, 2009, pp. 487-99.
Waitzberg DL, Torrinhas RS. Fish oil lipid emulsions and immune response: what clinicians need to know. Nutr Clin Pract. 2009;24(4):487-99.
Waitzberg, D. L., & Torrinhas, R. S. (2009). Fish oil lipid emulsions and immune response: what clinicians need to know. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 24(4), pp. 487-99. doi:10.1177/0884533609339071.
Waitzberg DL, Torrinhas RS. Fish Oil Lipid Emulsions and Immune Response: what Clinicians Need to Know. Nutr Clin Pract. 2009;24(4):487-99. PubMed PMID: 19605803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish oil lipid emulsions and immune response: what clinicians need to know. AU - Waitzberg,Dan Linetzky, AU - Torrinhas,Raquel Susana, PY - 2009/7/17/entrez PY - 2009/7/17/pubmed PY - 2009/10/2/medline SP - 487 EP - 99 JF - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JO - Nutr Clin Pract VL - 24 IS - 4 N2 - Current evidence indicates that omega-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid and docosahexaenoic acid found in fish oil, can prevent the development of inflammatory diseases by affecting different steps of the immune response. The capacity of omega-3 PUFAs to modulate synthesis of eicosanoids, activity of nuclear receptor and nuclear transcription factors, and production of resolvins may also mitigate inflammatory processes already present. Parenteral infusion of omega-3 PUFAs is advantageous, particularly in severely ill patients, because the fatty acids are rapidly incorporated by cells. In addition, when fatty acids are given parenterally, there are no losses from digestion and absorption as there are with enteral infusion. Recently, lipid emulsions enriched with omega-3 fish oil have been introduced as a component of parenteral nutrition. Currently, there is one lipid emulsion that contains only fish oil; it is infused together with conventionally used lipid emulsions. Other commercially available lipid emulsions contain fish oil in a fat mixture; one contains 10% fish oil and another 15% fish oil. Relevant experimental and clinical data from studies evaluating fish oil lipid emulsions are discussed in the present review. Administration of fish oil lipid emulsion, when compared with soybean oil lipid emulsion (rich in omega-6 PUFA), decreases the length of hospital and intensive care unit stay in surgical patients. SN - 0884-5336 UR - https://www.unboundmedicine.com/medline/citation/19605803/Fish_oil_lipid_emulsions_and_immune_response:_what_clinicians_need_to_know_ L2 - https://doi.org/10.1177/0884533609339071 DB - PRIME DP - Unbound Medicine ER -