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Antidiabetic effects of scoparic acid D isolated from Scoparia dulcis in rats with streptozotocin-induced diabetes.
Nat Prod Res. 2009; 23(16):1528-40.NP

Abstract

We evaluated the antihyperglycaemic effect of scoparic acid D (SAD), a diterpenoid isolated from the ethanol extract of Scoparia dulcis in streptozotocin (STZ)-induced diabetic male Wistar rats. SAD was administered orally at a dose of 10, 20 and 40 mg kg(-1) bodyweight for 15 days. At the end of the experimental period, the SAD-treated STZ diabetic rats showed decreased levels of glucose as compared with diabetic control rats. The improvement in blood glucose levels of SAD-treated rats was associated with a significant increase in plasma insulin levels. SAD at a dose of 20 mg kg(-1) bodyweight exhibited a significant effect when compared with other doses. Further, the effect of SAD was tested on STZ-treated rat insulinoma cell lines (RINm5F cells) and isolated islets in vitro. SAD at a dose of 20 microg mL(-1) evoked two-fold stimulation of insulin secretion from isolated islets, indicating its insulin secretagogue activity. Further, SAD protected STZ-mediated cytotoxicity and nitric oxide (NO) production in RINm5F cells. The present study thus confirms the antihyperglycaemic effect of SAD and also demonstrated the consistently strong cytoprotective properties of SAD.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Tamil Nadu, India. drlathamuniappan@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19606382

Citation

Latha, Muniappan, et al. "Antidiabetic Effects of Scoparic Acid D Isolated From Scoparia Dulcis in Rats With Streptozotocin-induced Diabetes." Natural Product Research, vol. 23, no. 16, 2009, pp. 1528-40.
Latha M, Pari L, Ramkumar KM, et al. Antidiabetic effects of scoparic acid D isolated from Scoparia dulcis in rats with streptozotocin-induced diabetes. Nat Prod Res. 2009;23(16):1528-40.
Latha, M., Pari, L., Ramkumar, K. M., Rajaguru, P., Suresh, T., Dhanabal, T., Sitasawad, S., & Bhonde, R. (2009). Antidiabetic effects of scoparic acid D isolated from Scoparia dulcis in rats with streptozotocin-induced diabetes. Natural Product Research, 23(16), 1528-40. https://doi.org/10.1080/14786410902726126
Latha M, et al. Antidiabetic Effects of Scoparic Acid D Isolated From Scoparia Dulcis in Rats With Streptozotocin-induced Diabetes. Nat Prod Res. 2009;23(16):1528-40. PubMed PMID: 19606382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic effects of scoparic acid D isolated from Scoparia dulcis in rats with streptozotocin-induced diabetes. AU - Latha,Muniappan, AU - Pari,Leelavinothan, AU - Ramkumar,Kunga Mohan, AU - Rajaguru,Palanisamy, AU - Suresh,Thangaraj, AU - Dhanabal,Thangavel, AU - Sitasawad,Sandhya, AU - Bhonde,Ramesh, PY - 2009/7/17/entrez PY - 2009/7/17/pubmed PY - 2010/1/14/medline SP - 1528 EP - 40 JF - Natural product research JO - Nat Prod Res VL - 23 IS - 16 N2 - We evaluated the antihyperglycaemic effect of scoparic acid D (SAD), a diterpenoid isolated from the ethanol extract of Scoparia dulcis in streptozotocin (STZ)-induced diabetic male Wistar rats. SAD was administered orally at a dose of 10, 20 and 40 mg kg(-1) bodyweight for 15 days. At the end of the experimental period, the SAD-treated STZ diabetic rats showed decreased levels of glucose as compared with diabetic control rats. The improvement in blood glucose levels of SAD-treated rats was associated with a significant increase in plasma insulin levels. SAD at a dose of 20 mg kg(-1) bodyweight exhibited a significant effect when compared with other doses. Further, the effect of SAD was tested on STZ-treated rat insulinoma cell lines (RINm5F cells) and isolated islets in vitro. SAD at a dose of 20 microg mL(-1) evoked two-fold stimulation of insulin secretion from isolated islets, indicating its insulin secretagogue activity. Further, SAD protected STZ-mediated cytotoxicity and nitric oxide (NO) production in RINm5F cells. The present study thus confirms the antihyperglycaemic effect of SAD and also demonstrated the consistently strong cytoprotective properties of SAD. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/19606382/Antidiabetic_effects_of_scoparic_acid_D_isolated_from_Scoparia_dulcis_in_rats_with_streptozotocin_induced_diabetes_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786410902726126 DB - PRIME DP - Unbound Medicine ER -