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Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense.
J Nat Prod. 2009 Aug; 72(8):1447-52.JN

Abstract

Biyouyanagiol (1), an acylphloroglucinol-related compound having a unique cyclopenta-1,3-dione moiety, was isolated from a Japanese traditional medicinal plant, Hypericum chinense, together with three new spiro-lactone-related derivatives, biyouyanagin B (2), 5,6-dihydrohyperolactone D (3), and 4-hydroxyhyperolactone D (4). Their structures were established on the basis of spectroscopic evidence. In a cytotoxicity assay against human cancer cell lines including multidrug-resistant (MDR) cancer cell lines, several compounds demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Tanaka N
Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
Kashiwada Y
No affiliation info available
Kim SY
No affiliation info available
Hashida W
No affiliation info available
Sekiya M
No affiliation info available
Ikeshiro Y
No affiliation info available
Takaishi Y
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicColchicineDrug Resistance, MultipleDrug Screening Assays, AntitumorHumansHypericumJapanKB CellsLactonesMolecular StructurePlant LeavesPlants, MedicinalSesquiterpenesSpiro Compounds

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19606850

Citation

Tanaka, Naonobu, et al. "Acylphloroglucinol, Biyouyanagiol, Biyouyanagin B, and Related Spiro-lactones From Hypericum Chinense." Journal of Natural Products, vol. 72, no. 8, 2009, pp. 1447-52.
Tanaka N, Kashiwada Y, Kim SY, et al. Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense. J Nat Prod. 2009;72(8):1447-52.
Tanaka, N., Kashiwada, Y., Kim, S. Y., Hashida, W., Sekiya, M., Ikeshiro, Y., & Takaishi, Y. (2009). Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense. Journal of Natural Products, 72(8), 1447-52. https://doi.org/10.1021/np900109y
Tanaka N, et al. Acylphloroglucinol, Biyouyanagiol, Biyouyanagin B, and Related Spiro-lactones From Hypericum Chinense. J Nat Prod. 2009;72(8):1447-52. PubMed PMID: 19606850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense. AU - Tanaka,Naonobu, AU - Kashiwada,Yoshiki, AU - Kim,Sang Yong, AU - Hashida,Waka, AU - Sekiya,Michiko, AU - Ikeshiro,Yasumasa, AU - Takaishi,Yoshihisa, PY - 2009/7/18/entrez PY - 2009/7/18/pubmed PY - 2009/10/15/medline SP - 1447 EP - 52 JF - Journal of natural products JO - J Nat Prod VL - 72 IS - 8 N2 - Biyouyanagiol (1), an acylphloroglucinol-related compound having a unique cyclopenta-1,3-dione moiety, was isolated from a Japanese traditional medicinal plant, Hypericum chinense, together with three new spiro-lactone-related derivatives, biyouyanagin B (2), 5,6-dihydrohyperolactone D (3), and 4-hydroxyhyperolactone D (4). Their structures were established on the basis of spectroscopic evidence. In a cytotoxicity assay against human cancer cell lines including multidrug-resistant (MDR) cancer cell lines, several compounds demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/19606850/Acylphloroglucinol_biyouyanagiol_biyouyanagin_B_and_related_spiro_lactones_from_Hypericum_chinense_ L2 - https://doi.org/10.1021/np900109y DB - PRIME DP - Unbound Medicine ER -