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Single-pill combination of amlodipine and valsartan in the management of hypertension.
Expert Opin Pharmacother. 2009 Aug; 10(12):1979-94.EO

Abstract

Combination therapy is increasingly recommended for selected patients with hypertension to facilitate prompt attainment and maintenance of goal blood pressure (BP). Single-pill combination therapy simplifies treatment and optimizes long-term compliance. Amlodipine, a dihydropyridine calcium antagonist, and valsartan, an angiotensin receptor blocker, are well-established antihypertensive agents with complementary mechanisms of action. This combination lowers BP significantly more than either of its components, and valsartan reduces the incidence of dose-related amlodipine-induced edema. Rigorous clinical trial data have proven the BP-lowering efficacy and high tolerability of the amlodipine/valsartan combination in patients with moderate to severe hypertension as well as other difficult-to-treat populations. Amlodipine/valsartan is indicated as initial therapy in patients who are unlikely to be controlled with a single drug and as second-line therapy in patients not responding adequately to monotherapy.

Authors+Show Affiliations

Department of Internal Medicine, Wayne State University School of Medicine, 4201 St. Antoine, Suite 2E, Detroit, MI 48201, USA. jflack@med.wayne.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19606937

Citation

Flack, John M., and Robert Hilkert. "Single-pill Combination of Amlodipine and Valsartan in the Management of Hypertension." Expert Opinion On Pharmacotherapy, vol. 10, no. 12, 2009, pp. 1979-94.
Flack JM, Hilkert R. Single-pill combination of amlodipine and valsartan in the management of hypertension. Expert Opin Pharmacother. 2009;10(12):1979-94.
Flack, J. M., & Hilkert, R. (2009). Single-pill combination of amlodipine and valsartan in the management of hypertension. Expert Opinion On Pharmacotherapy, 10(12), 1979-94. https://doi.org/10.1517/14656560903120899
Flack JM, Hilkert R. Single-pill Combination of Amlodipine and Valsartan in the Management of Hypertension. Expert Opin Pharmacother. 2009;10(12):1979-94. PubMed PMID: 19606937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single-pill combination of amlodipine and valsartan in the management of hypertension. AU - Flack,John M, AU - Hilkert,Robert, PY - 2009/7/18/entrez PY - 2009/7/18/pubmed PY - 2009/10/1/medline SP - 1979 EP - 94 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 10 IS - 12 N2 - Combination therapy is increasingly recommended for selected patients with hypertension to facilitate prompt attainment and maintenance of goal blood pressure (BP). Single-pill combination therapy simplifies treatment and optimizes long-term compliance. Amlodipine, a dihydropyridine calcium antagonist, and valsartan, an angiotensin receptor blocker, are well-established antihypertensive agents with complementary mechanisms of action. This combination lowers BP significantly more than either of its components, and valsartan reduces the incidence of dose-related amlodipine-induced edema. Rigorous clinical trial data have proven the BP-lowering efficacy and high tolerability of the amlodipine/valsartan combination in patients with moderate to severe hypertension as well as other difficult-to-treat populations. Amlodipine/valsartan is indicated as initial therapy in patients who are unlikely to be controlled with a single drug and as second-line therapy in patients not responding adequately to monotherapy. SN - 1744-7666 UR - https://www.unboundmedicine.com/medline/citation/19606937/Single_pill_combination_of_amlodipine_and_valsartan_in_the_management_of_hypertension_ L2 - http://www.tandfonline.com/doi/full/10.1517/14656560903120899 DB - PRIME DP - Unbound Medicine ER -