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Free radical scavenging and antiatherogenic activities of Sesamum indicum seed extracts in chemical and biological model systems.
Food Chem Toxicol. 2009 Oct; 47(10):2507-15.FC

Abstract

An emerging consensus underscores the importance of oxidative events in vascular disease including excess production of reactive oxygen/nitrogen species (ROS/RNS), in addition to lipoprotein oxidation. Sesamum indicum has long been used extensively as a traditional food. The aim of present study was to evaluate antioxidant action of aqueous and ethanolic seed extracts from S. indicum using various in vitro ROS/RNS generated chemical and biological models. Results demonstrated that the graded-dose (25-1000 microg/ml) of aqueous and ethanolic extracts markedly scavenged the nitric oxide, superoxide, hydroxyl, 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radicals and, showed metal chelating ability as well as reducing capacity in Fe(3+)/ferricyanide complex and ferric reducing antioxidant power assays. In biological models, both extracts were found to inhibit metal-induced lipid peroxidation in mitochondrial fractions, human serum and LDL oxidation models. In lipoprotein kinetics study, both extracts significantly (P<0.05) increased lag phase time along with reduced oxidation rate and conjugated dienes production. Ethanolic extract of S. indicum showed higher amounts of total polyphenol and flavonoid content as compared to their counterpart. The IC(50) values of both extracts were compared with respective antioxidant standards. Overall, ethanolic extract of S. indicum possess strong antioxidant capacity and offering effective protection against LDL oxidation susceptibility.

Authors+Show Affiliations

BRD School of Biosciences, Sardar Patel Maidan, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India. nishantpv@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19607871

Citation

Visavadiya, Nishant P., et al. "Free Radical Scavenging and Antiatherogenic Activities of Sesamum Indicum Seed Extracts in Chemical and Biological Model Systems." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 10, 2009, pp. 2507-15.
Visavadiya NP, Soni B, Dalwadi N. Free radical scavenging and antiatherogenic activities of Sesamum indicum seed extracts in chemical and biological model systems. Food Chem Toxicol. 2009;47(10):2507-15.
Visavadiya, N. P., Soni, B., & Dalwadi, N. (2009). Free radical scavenging and antiatherogenic activities of Sesamum indicum seed extracts in chemical and biological model systems. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(10), 2507-15. https://doi.org/10.1016/j.fct.2009.07.009
Visavadiya NP, Soni B, Dalwadi N. Free Radical Scavenging and Antiatherogenic Activities of Sesamum Indicum Seed Extracts in Chemical and Biological Model Systems. Food Chem Toxicol. 2009;47(10):2507-15. PubMed PMID: 19607871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Free radical scavenging and antiatherogenic activities of Sesamum indicum seed extracts in chemical and biological model systems. AU - Visavadiya,Nishant P, AU - Soni,Badrish, AU - Dalwadi,Nirav, Y1 - 2009/07/14/ PY - 2009/04/05/received PY - 2009/06/27/revised PY - 2009/07/09/accepted PY - 2009/7/18/entrez PY - 2009/7/18/pubmed PY - 2009/12/16/medline SP - 2507 EP - 15 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 10 N2 - An emerging consensus underscores the importance of oxidative events in vascular disease including excess production of reactive oxygen/nitrogen species (ROS/RNS), in addition to lipoprotein oxidation. Sesamum indicum has long been used extensively as a traditional food. The aim of present study was to evaluate antioxidant action of aqueous and ethanolic seed extracts from S. indicum using various in vitro ROS/RNS generated chemical and biological models. Results demonstrated that the graded-dose (25-1000 microg/ml) of aqueous and ethanolic extracts markedly scavenged the nitric oxide, superoxide, hydroxyl, 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radicals and, showed metal chelating ability as well as reducing capacity in Fe(3+)/ferricyanide complex and ferric reducing antioxidant power assays. In biological models, both extracts were found to inhibit metal-induced lipid peroxidation in mitochondrial fractions, human serum and LDL oxidation models. In lipoprotein kinetics study, both extracts significantly (P<0.05) increased lag phase time along with reduced oxidation rate and conjugated dienes production. Ethanolic extract of S. indicum showed higher amounts of total polyphenol and flavonoid content as compared to their counterpart. The IC(50) values of both extracts were compared with respective antioxidant standards. Overall, ethanolic extract of S. indicum possess strong antioxidant capacity and offering effective protection against LDL oxidation susceptibility. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19607871/Free_radical_scavenging_and_antiatherogenic_activities_of_Sesamum_indicum_seed_extracts_in_chemical_and_biological_model_systems_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00336-6 DB - PRIME DP - Unbound Medicine ER -