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Anti-nociceptive and anti-inflammatory activity of sophocarpine.
J Ethnopharmacol. 2009 Sep 07; 125(2):324-9.JE

Abstract

AIM OF THE STUDY

This study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents.

MATERIALS AND METHODS

The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above study.

RESULTS

Pretreatment with a single dose of sophocarpine (20 and 40 mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30 mg/kg), xylene-induced mouse ear edema (20 and 40 mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40 mg/kg).

CONCLUSIONS

Sophocarpine possesses peripheral and central analgesic properties as well as anti-inflammatory activity on acute inflammatory processes.

Authors+Show Affiliations

College of Food Science and Engineering, Ocean University of China, Qingdao Shandong Province 266003, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19607897

Citation

Gao, Yonglin, et al. "Anti-nociceptive and Anti-inflammatory Activity of Sophocarpine." Journal of Ethnopharmacology, vol. 125, no. 2, 2009, pp. 324-9.
Gao Y, Li G, Li C, et al. Anti-nociceptive and anti-inflammatory activity of sophocarpine. J Ethnopharmacol. 2009;125(2):324-9.
Gao, Y., Li, G., Li, C., Zhu, X., Li, M., Fu, C., & Li, B. (2009). Anti-nociceptive and anti-inflammatory activity of sophocarpine. Journal of Ethnopharmacology, 125(2), 324-9. https://doi.org/10.1016/j.jep.2009.06.036
Gao Y, et al. Anti-nociceptive and Anti-inflammatory Activity of Sophocarpine. J Ethnopharmacol. 2009 Sep 7;125(2):324-9. PubMed PMID: 19607897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-nociceptive and anti-inflammatory activity of sophocarpine. AU - Gao,Yonglin, AU - Li,Guisheng, AU - Li,Chunmei, AU - Zhu,Xiaoyin, AU - Li,Min, AU - Fu,Chaolin, AU - Li,Bafang, Y1 - 2009/07/14/ PY - 2009/01/20/received PY - 2009/05/27/revised PY - 2009/06/17/accepted PY - 2009/7/18/entrez PY - 2009/7/18/pubmed PY - 2009/12/16/medline SP - 324 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 125 IS - 2 N2 - AIM OF THE STUDY: This study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents. MATERIALS AND METHODS: The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above study. RESULTS: Pretreatment with a single dose of sophocarpine (20 and 40 mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30 mg/kg), xylene-induced mouse ear edema (20 and 40 mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40 mg/kg). CONCLUSIONS: Sophocarpine possesses peripheral and central analgesic properties as well as anti-inflammatory activity on acute inflammatory processes. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19607897/Anti_nociceptive_and_anti_inflammatory_activity_of_sophocarpine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00388-2 DB - PRIME DP - Unbound Medicine ER -