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Evaluation of healing and antimicrobiological effects of herbal therapy on venous leg ulcer: pilot study.

Abstract

Venous leg ulcers represent a significant public health problem that will increase as the population ages. Numerous herbs and their extracts are potentially conducive to wound healing, including the ability to serve as an antimicrobial, antifungal, astringent, etc. A total of 32 patients with venous leg ulcers were randomized into two groups: a group with herbal therapy treatment (PT) (17 patients) and a control group (C) (15 patients). The investigation focused on five controls of parameter changes important for ulcer healing and the control of microbiological flora. Within-treatment analysis of the PT group showed that, following herbal therapy treatment, there was a significant decrease in the scores of surface leg ulcer and venous leg ulcer after week 7 of treatment (p < 0.05). In group C following topical antibiotic treatment there was no significant decrease in the surface leg ulcer. Comparing the results of decreased venous leg ulcer surface of the) PT group with the C group showed a significant difference at p < 0.05 after week 7 of treatment. The number of different types of isolated bacterial species decreased significantly (p < 0.05) after the use of herbal preparations. The results of this pilot study demonstrate the healing and antimicrobiological effects of herbal therapy on non-infected venous leg ulcer.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Clinic of Dermatology and Venereology, Clinical Center Nis, Nis, Serbia.

    , , ,

    Source

    Phytotherapy research : PTR 24:2 2010 Feb pg 277-82

    MeSH

    Administration, Cutaneous
    Aged
    Aged, 80 and over
    Anti-Bacterial Agents
    Female
    Humans
    Male
    Middle Aged
    Phytotherapy
    Pilot Projects
    Plant Preparations
    Treatment Outcome
    Varicose Ulcer
    Wound Healing

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    19610037

    Citation

    Binić, Ivana, et al. "Evaluation of Healing and Antimicrobiological Effects of Herbal Therapy On Venous Leg Ulcer: Pilot Study." Phytotherapy Research : PTR, vol. 24, no. 2, 2010, pp. 277-82.
    Binić I, Janković A, Janković D, et al. Evaluation of healing and antimicrobiological effects of herbal therapy on venous leg ulcer: pilot study. Phytother Res. 2010;24(2):277-82.
    Binić, I., Janković, A., Janković, D., Janković, I., & Vrucinić, Z. (2010). Evaluation of healing and antimicrobiological effects of herbal therapy on venous leg ulcer: pilot study. Phytotherapy Research : PTR, 24(2), pp. 277-82. doi:10.1002/ptr.2931.
    Binić I, et al. Evaluation of Healing and Antimicrobiological Effects of Herbal Therapy On Venous Leg Ulcer: Pilot Study. Phytother Res. 2010;24(2):277-82. PubMed PMID: 19610037.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evaluation of healing and antimicrobiological effects of herbal therapy on venous leg ulcer: pilot study. AU - Binić,Ivana, AU - Janković,Aleksandar, AU - Janković,Dimitrije, AU - Janković,Irena, AU - Vrucinić,Zoran, PY - 2009/7/18/entrez PY - 2009/7/18/pubmed PY - 2010/2/27/medline SP - 277 EP - 82 JF - Phytotherapy research : PTR JO - Phytother Res VL - 24 IS - 2 N2 - Venous leg ulcers represent a significant public health problem that will increase as the population ages. Numerous herbs and their extracts are potentially conducive to wound healing, including the ability to serve as an antimicrobial, antifungal, astringent, etc. A total of 32 patients with venous leg ulcers were randomized into two groups: a group with herbal therapy treatment (PT) (17 patients) and a control group (C) (15 patients). The investigation focused on five controls of parameter changes important for ulcer healing and the control of microbiological flora. Within-treatment analysis of the PT group showed that, following herbal therapy treatment, there was a significant decrease in the scores of surface leg ulcer and venous leg ulcer after week 7 of treatment (p < 0.05). In group C following topical antibiotic treatment there was no significant decrease in the surface leg ulcer. Comparing the results of decreased venous leg ulcer surface of the) PT group with the C group showed a significant difference at p < 0.05 after week 7 of treatment. The number of different types of isolated bacterial species decreased significantly (p < 0.05) after the use of herbal preparations. The results of this pilot study demonstrate the healing and antimicrobiological effects of herbal therapy on non-infected venous leg ulcer. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/19610037/Evaluation_of_healing_and_antimicrobiological_effects_of_herbal_therapy_on_venous_leg_ulcer:_pilot_study_ L2 - https://doi.org/10.1002/ptr.2931 DB - PRIME DP - Unbound Medicine ER -