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Eczematous skin reaction to atopy patch testing with cockroach in patients with atopic dermatitis.
J Investig Allergol Clin Immunol. 2009; 19(3):173-9.JI

Abstract

BACKGROUND

Aeroallergens from house dust mite (HDM) may be an important trigger in a subgroup of patients with atopic dermatitis (AD). HDM and cockroach (CR) contain cross-reactive allergens, such as tropomyosin.

OBJECTIVE

To investigate the diagnostic value of patch testing with an aeroallergen and the role of CR allergen and HDM allergen in persons with AD.

METHODS

We performed skin prick tests (SPT) with a panel of common aeroallergens and total serum immunoglobulin (Ig)E and specific IgE tests for CR and HDM on 23 patients with AD and 9 nonatopic control participants. Atopy patch tests (APT) were performed with CR and HDM extracts on clinically uninvolved skin on the back, and evaluated after 48 and 72 hours.

RESULTS

A positive APT reaction to CR was found in 10/23 (43%) patients with AD. No positive reactions were observed in the nonatopic control participants. Positive APT reactions for CR showed no significant correlation with SPT or specific IgE levels for this allergen. Twelve of the 23 (52%) patients with AD were also sensitized to HDM. There was no significant correlation between positive results for SPT, APT, and specific IgE to CR and HDM.

CONCLUSION

We demonstrate that CR allergens can induce positive patch test reactions in patients with AD. The absence of a significant correlation to SPT and specific IgE antibodies suggests that T-cell- and IgE-sensitization may be mediated by different allergens. There was no significant relationship between CR and HDM sensitivity, thus indicating no major cross-reactivity.

Authors+Show Affiliations

Michel S
University Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, University of Bern, Switzerland.
Yawalkar N
No affiliation info available
Schnyder B
No affiliation info available
Fischer B
No affiliation info available
Helbling A
No affiliation info available

MeSH

AdolescentAdultAgedAllergensAnimalsChildCockroachesCross ReactionsDermatitis, AtopicEczemaFemaleHumansImmunoglobulin EMaleMiddle AgedPatch TestsPyroglyphidaeSurveys and QuestionnairesYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19610259

Citation

Michel, S, et al. "Eczematous Skin Reaction to Atopy Patch Testing With Cockroach in Patients With Atopic Dermatitis." Journal of Investigational Allergology & Clinical Immunology, vol. 19, no. 3, 2009, pp. 173-9.
Michel S, Yawalkar N, Schnyder B, et al. Eczematous skin reaction to atopy patch testing with cockroach in patients with atopic dermatitis. J Investig Allergol Clin Immunol. 2009;19(3):173-9.
Michel, S., Yawalkar, N., Schnyder, B., Fischer, B., & Helbling, A. (2009). Eczematous skin reaction to atopy patch testing with cockroach in patients with atopic dermatitis. Journal of Investigational Allergology & Clinical Immunology, 19(3), 173-9.
Michel S, et al. Eczematous Skin Reaction to Atopy Patch Testing With Cockroach in Patients With Atopic Dermatitis. J Investig Allergol Clin Immunol. 2009;19(3):173-9. PubMed PMID: 19610259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eczematous skin reaction to atopy patch testing with cockroach in patients with atopic dermatitis. AU - Michel,S, AU - Yawalkar,N, AU - Schnyder,B, AU - Fischer,B, AU - Helbling,A, PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2009/8/11/medline SP - 173 EP - 9 JF - Journal of investigational allergology & clinical immunology JO - J Investig Allergol Clin Immunol VL - 19 IS - 3 N2 - BACKGROUND: Aeroallergens from house dust mite (HDM) may be an important trigger in a subgroup of patients with atopic dermatitis (AD). HDM and cockroach (CR) contain cross-reactive allergens, such as tropomyosin. OBJECTIVE: To investigate the diagnostic value of patch testing with an aeroallergen and the role of CR allergen and HDM allergen in persons with AD. METHODS: We performed skin prick tests (SPT) with a panel of common aeroallergens and total serum immunoglobulin (Ig)E and specific IgE tests for CR and HDM on 23 patients with AD and 9 nonatopic control participants. Atopy patch tests (APT) were performed with CR and HDM extracts on clinically uninvolved skin on the back, and evaluated after 48 and 72 hours. RESULTS: A positive APT reaction to CR was found in 10/23 (43%) patients with AD. No positive reactions were observed in the nonatopic control participants. Positive APT reactions for CR showed no significant correlation with SPT or specific IgE levels for this allergen. Twelve of the 23 (52%) patients with AD were also sensitized to HDM. There was no significant correlation between positive results for SPT, APT, and specific IgE to CR and HDM. CONCLUSION: We demonstrate that CR allergens can induce positive patch test reactions in patients with AD. The absence of a significant correlation to SPT and specific IgE antibodies suggests that T-cell- and IgE-sensitization may be mediated by different allergens. There was no significant relationship between CR and HDM sensitivity, thus indicating no major cross-reactivity. SN - 1018-9068 UR - https://www.unboundmedicine.com/medline/citation/19610259/Eczematous_skin_reaction_to_atopy_patch_testing_with_cockroach_in_patients_with_atopic_dermatitis_ DB - PRIME DP - Unbound Medicine ER -