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Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report.
J Cutan Pathol 2010; 37(6):683-6JC

Abstract

BACKGROUND

Extramammary Paget's disease (EMPD) is an uncommon skin neoplasm characterized by Paget's cells with pale-staining cytoplasm in the epidermis, and cases with distinguished acantholysis but lacking characteristic Paget's cells were rarely reported in the literature.

METHODS

An 80-year-old male with lesion on scrotum was screened histologically and immunohistologically for the diagnosis of his tumor.

RESULTS

Histological examination showed acanthosis with cellular atypia and focal acantholysis, consistent with acantholytic squamous cell carcinoma in situ (SCCIS). No characteristic Paget's cells were observed in low magnification. Immunohistochemical staining showed carcinoembryonic antigen (CEA), cytokeratin 7 (CK7) and cytokeratin 8 (CK8) to be strongly expressed in the nests and singly arranged large tumor cells, and the surrounding epidermis was positive for CK5/6 and negative for CEA. Sporadic periodic acid-schiff (PAS)-positive cells could be seen in some areas.

CONCLUSIONS

These findings strongly indicated the diagnosis of EMPD mimicking acantholytic SCCIS.

Authors+Show Affiliations

Department of Dermatology, Wuxi People's Hospital, Wuxi 214023, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19615013

Citation

Du, Xufeng, et al. "Extramammary Paget's Disease Mimicking Acantholytic Squamous Cell Carcinoma in Situ: a Case Report." Journal of Cutaneous Pathology, vol. 37, no. 6, 2010, pp. 683-6.
Du X, Yin X, Zhou N, et al. Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report. J Cutan Pathol. 2010;37(6):683-6.
Du, X., Yin, X., Zhou, N., Zhang, G., Shi, H., & Cao, S. (2010). Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report. Journal of Cutaneous Pathology, 37(6), pp. 683-6. doi:10.1111/j.1600-0560.2009.01336.x.
Du X, et al. Extramammary Paget's Disease Mimicking Acantholytic Squamous Cell Carcinoma in Situ: a Case Report. J Cutan Pathol. 2010;37(6):683-6. PubMed PMID: 19615013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report. AU - Du,Xufeng, AU - Yin,Xingping, AU - Zhou,Nan, AU - Zhang,Guolong, AU - Shi,Hejian, AU - Cao,Shuanglin, Y1 - 2009/07/14/ PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2010/9/4/medline SP - 683 EP - 6 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 37 IS - 6 N2 - BACKGROUND: Extramammary Paget's disease (EMPD) is an uncommon skin neoplasm characterized by Paget's cells with pale-staining cytoplasm in the epidermis, and cases with distinguished acantholysis but lacking characteristic Paget's cells were rarely reported in the literature. METHODS: An 80-year-old male with lesion on scrotum was screened histologically and immunohistologically for the diagnosis of his tumor. RESULTS: Histological examination showed acanthosis with cellular atypia and focal acantholysis, consistent with acantholytic squamous cell carcinoma in situ (SCCIS). No characteristic Paget's cells were observed in low magnification. Immunohistochemical staining showed carcinoembryonic antigen (CEA), cytokeratin 7 (CK7) and cytokeratin 8 (CK8) to be strongly expressed in the nests and singly arranged large tumor cells, and the surrounding epidermis was positive for CK5/6 and negative for CEA. Sporadic periodic acid-schiff (PAS)-positive cells could be seen in some areas. CONCLUSIONS: These findings strongly indicated the diagnosis of EMPD mimicking acantholytic SCCIS. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/19615013/Extramammary_Paget's_disease_mimicking_acantholytic_squamous_cell_carcinoma_in_situ:_a_case_report_ L2 - https://doi.org/10.1111/j.1600-0560.2009.01336.x DB - PRIME DP - Unbound Medicine ER -