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Obesity and metabolic syndrome-related chronic kidney disease in nondiabetic, nonhypertensive adults.
Metabolism. 2009 Dec; 58(12):1737-42.M

Abstract

Metabolic syndrome (MS) is associated with chronic kidney disease (CKD). The objective of this study is to examine the association between obesity and MS-related CKD in nondiabetic, nonhypertensive Korean adults. Korea National Health and Nutrition Examination Survey III data from 3771 nondiabetic, nonhypertensive Koreans were analyzed. Metabolic syndrome was defined according to the National Cholesterol Education Program-Adult Treatment Panel III, and CKD was diagnosed at an estimated glomerular filtration rate less than 60 mL/(min 1.73 m(2)). The crude and multivariate-adjusted odds ratios (ORs) of CKD associated with MS and its individual components were calculated using logistic regression models in a study population stratified by obesity. The prevalence of MS and CKD was 13.4% and 3.2%, respectively. The association between MS and CKD was significant in obese (OR, 2.91; 95% confidence interval [CI] = 1.34-6.34), but not nonobese (OR, 1.38; 95% CI = 0.60-3.17), subjects. In obese subjects, impaired fasting glucose (OR, 2.47; 95% CI = 1.10-5.57) and high triglyceride levels (OR, 2.42; 95% CI = 1.01-5.83) were risk factors for CKD, whereas no components were significantly associated with CKD in nonobese subjects. Our findings suggest that even in nondiabetic, nonhypertensive Korean adults, early detection and prevention of CKD in obese subjects with MS are critical.

Authors+Show Affiliations

Department of Family Medicine, Ilsan Paik Hospital, University of Inje College of Medicine. Gyeonggi-do 410-706, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19615700

Citation

Yoon, Yeong Sook, et al. "Obesity and Metabolic Syndrome-related Chronic Kidney Disease in Nondiabetic, Nonhypertensive Adults." Metabolism: Clinical and Experimental, vol. 58, no. 12, 2009, pp. 1737-42.
Yoon YS, Park HS, Yun KE, et al. Obesity and metabolic syndrome-related chronic kidney disease in nondiabetic, nonhypertensive adults. Metabolism. 2009;58(12):1737-42.
Yoon, Y. S., Park, H. S., Yun, K. E., & Kim, S. B. (2009). Obesity and metabolic syndrome-related chronic kidney disease in nondiabetic, nonhypertensive adults. Metabolism: Clinical and Experimental, 58(12), 1737-42. https://doi.org/10.1016/j.metabol.2009.05.029
Yoon YS, et al. Obesity and Metabolic Syndrome-related Chronic Kidney Disease in Nondiabetic, Nonhypertensive Adults. Metabolism. 2009;58(12):1737-42. PubMed PMID: 19615700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity and metabolic syndrome-related chronic kidney disease in nondiabetic, nonhypertensive adults. AU - Yoon,Yeong Sook, AU - Park,Hye Soon, AU - Yun,Kyung Eun, AU - Kim,Soon Bae, Y1 - 2009/07/16/ PY - 2008/10/06/received PY - 2009/05/29/accepted PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2009/12/16/medline SP - 1737 EP - 42 JF - Metabolism: clinical and experimental JO - Metabolism VL - 58 IS - 12 N2 - Metabolic syndrome (MS) is associated with chronic kidney disease (CKD). The objective of this study is to examine the association between obesity and MS-related CKD in nondiabetic, nonhypertensive Korean adults. Korea National Health and Nutrition Examination Survey III data from 3771 nondiabetic, nonhypertensive Koreans were analyzed. Metabolic syndrome was defined according to the National Cholesterol Education Program-Adult Treatment Panel III, and CKD was diagnosed at an estimated glomerular filtration rate less than 60 mL/(min 1.73 m(2)). The crude and multivariate-adjusted odds ratios (ORs) of CKD associated with MS and its individual components were calculated using logistic regression models in a study population stratified by obesity. The prevalence of MS and CKD was 13.4% and 3.2%, respectively. The association between MS and CKD was significant in obese (OR, 2.91; 95% confidence interval [CI] = 1.34-6.34), but not nonobese (OR, 1.38; 95% CI = 0.60-3.17), subjects. In obese subjects, impaired fasting glucose (OR, 2.47; 95% CI = 1.10-5.57) and high triglyceride levels (OR, 2.42; 95% CI = 1.01-5.83) were risk factors for CKD, whereas no components were significantly associated with CKD in nonobese subjects. Our findings suggest that even in nondiabetic, nonhypertensive Korean adults, early detection and prevention of CKD in obese subjects with MS are critical. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19615700/Obesity_and_metabolic_syndrome_related_chronic_kidney_disease_in_nondiabetic_nonhypertensive_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(09)00244-3 DB - PRIME DP - Unbound Medicine ER -