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Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors.
J Reprod Immunol 2009; 82(2):142-7JR

Abstract

Natural killer (NK) cells represent the major lymphocyte population in the decidua basalis of the human uterus during healthy early pregnancy. The activity of decidual NK (dNK) cells and their activation status are different from those of peripheral blood (PB)-NK cells; i.e. dNK cells exhibit a unique phenotype. Decidual NK cells have been defined as CD56(bright), CD16(neg), and more recently CD160(neg). They express a unique repertoire of NK cell receptors, identical among all donors tested. Decidual NK cells express in particular NKp46-, NKp30- and NKp44-activating receptors, contrasting with PB-NK cells which are devoid of NKp44-activating receptors. Specific engagement of each of these three so-called natural cytotoxicity receptors in dNK cells has important functional consequences in terms of cytokine, chemokine and angiogenic factor secretion as well as cytotoxic potential. Strikingly, and in contrast with PB-NK cells, engagement of NKp46- but not NKp30-activating receptor on freshly isolated dNK cells triggers cytotoxicity. Such cytotoxic potential of dNK cells is negatively controlled by NKG2A inhibitory receptor co-engagement. This suggests that in situ, dNK cells cannot kill trophoblast cells during normal pregnancy. Whether such NKG2A-mediated inhibition is abolished during pregnancies complicated by pathologies including viral infection is an interesting hypothesis that remains to be tested.

Authors+Show Affiliations

Institut National de la Santé et de la Recherche Médicale, U563, Toulouse, F-31300, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19615756

Citation

El Costa, Hicham, et al. "Effector Functions of Human Decidual NK Cells in Healthy Early Pregnancy Are Dependent On the Specific Engagement of Natural Cytotoxicity Receptors." Journal of Reproductive Immunology, vol. 82, no. 2, 2009, pp. 142-7.
El Costa H, Tabiasco J, Berrebi A, et al. Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors. J Reprod Immunol. 2009;82(2):142-7.
El Costa, H., Tabiasco, J., Berrebi, A., Parant, O., Aguerre-Girr, M., Piccinni, M. P., & Le Bouteiller, P. (2009). Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors. Journal of Reproductive Immunology, 82(2), pp. 142-7. doi:10.1016/j.jri.2009.06.123.
El Costa H, et al. Effector Functions of Human Decidual NK Cells in Healthy Early Pregnancy Are Dependent On the Specific Engagement of Natural Cytotoxicity Receptors. J Reprod Immunol. 2009;82(2):142-7. PubMed PMID: 19615756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors. AU - El Costa,Hicham, AU - Tabiasco,Julie, AU - Berrebi,Alain, AU - Parant,Olivier, AU - Aguerre-Girr,Maryse, AU - Piccinni,Marie-Pierre, AU - Le Bouteiller,Philippe, Y1 - 2009/07/16/ PY - 2009/04/02/received PY - 2009/05/27/revised PY - 2009/06/05/accepted PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2010/6/15/medline SP - 142 EP - 7 JF - Journal of reproductive immunology JO - J. Reprod. Immunol. VL - 82 IS - 2 N2 - Natural killer (NK) cells represent the major lymphocyte population in the decidua basalis of the human uterus during healthy early pregnancy. The activity of decidual NK (dNK) cells and their activation status are different from those of peripheral blood (PB)-NK cells; i.e. dNK cells exhibit a unique phenotype. Decidual NK cells have been defined as CD56(bright), CD16(neg), and more recently CD160(neg). They express a unique repertoire of NK cell receptors, identical among all donors tested. Decidual NK cells express in particular NKp46-, NKp30- and NKp44-activating receptors, contrasting with PB-NK cells which are devoid of NKp44-activating receptors. Specific engagement of each of these three so-called natural cytotoxicity receptors in dNK cells has important functional consequences in terms of cytokine, chemokine and angiogenic factor secretion as well as cytotoxic potential. Strikingly, and in contrast with PB-NK cells, engagement of NKp46- but not NKp30-activating receptor on freshly isolated dNK cells triggers cytotoxicity. Such cytotoxic potential of dNK cells is negatively controlled by NKG2A inhibitory receptor co-engagement. This suggests that in situ, dNK cells cannot kill trophoblast cells during normal pregnancy. Whether such NKG2A-mediated inhibition is abolished during pregnancies complicated by pathologies including viral infection is an interesting hypothesis that remains to be tested. SN - 1872-7603 UR - https://www.unboundmedicine.com/medline/citation/19615756/Effector_functions_of_human_decidual_NK_cells_in_healthy_early_pregnancy_are_dependent_on_the_specific_engagement_of_natural_cytotoxicity_receptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0378(09)00250-2 DB - PRIME DP - Unbound Medicine ER -