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Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats.
Exp Toxicol Pathol 2010; 62(5):471-81ET

Abstract

The aim of this study was to investigate the possible protective role of the dietary flavonoid quercetin on cadmium (Cd)-induced nephrotoxicity using biochemical and histopathological approaches. In experimental rats oral administration of CdCl(2) (5mg/kg) for 4 weeks significantly induced renal damage which was evident from the increased levels of serum urea, uric acid and creatinine with a significant (p<0.05) decrease in creatinine clearance. Cd also significantly (p<0.05) decreased the levels of urea, uric acid and creatinine in urine. Cd-induced oxidative stress in kidney tissue was indicated by the increased levels of renal lipid peroxidation markers (thiobarbituric acid reactive substances and lipid hydroperoxides) and protein carbonyl content with a significant (p<0.05) decrease in non-enzymatic (total sulphydryl group, reduced glutathione, vitamin C and vitamin E) and enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR) and glucose 6-phosphate dehydrogenase (G6PD)). Moreover the kidneys of Cd-treated rats showed tubular necrosis, degeneration, dilation, desquamation, thickening of basement membrane and luminal cast formation. Quercetin treatment markedly attenuated the Cd-induced biochemical alterations in serum, urine and renal tissue. Quercetin also ameliorated the Cd-induced pathological changes when compared with Cd-alone-treated group. These data indicate that the natural dietary antioxidant quercetin might have protective effect against Cd-induced nephrotoxicity and oxidative stress in rats.

Authors+Show Affiliations

Department of Zoology, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19615871

Citation

Renugadevi, J, and S Milton Prabu. "Quercetin Protects Against Oxidative Stress-related Renal Dysfunction By Cadmium in Rats." Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, vol. 62, no. 5, 2010, pp. 471-81.
Renugadevi J, Prabu SM. Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Exp Toxicol Pathol. 2010;62(5):471-81.
Renugadevi, J., & Prabu, S. M. (2010). Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 62(5), pp. 471-81. doi:10.1016/j.etp.2009.06.006.
Renugadevi J, Prabu SM. Quercetin Protects Against Oxidative Stress-related Renal Dysfunction By Cadmium in Rats. Exp Toxicol Pathol. 2010;62(5):471-81. PubMed PMID: 19615871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. AU - Renugadevi,J, AU - Prabu,S Milton, Y1 - 2009/07/16/ PY - 2009/04/08/received PY - 2009/05/16/revised PY - 2009/06/22/accepted PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2010/12/14/medline SP - 471 EP - 81 JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie JO - Exp. Toxicol. Pathol. VL - 62 IS - 5 N2 - The aim of this study was to investigate the possible protective role of the dietary flavonoid quercetin on cadmium (Cd)-induced nephrotoxicity using biochemical and histopathological approaches. In experimental rats oral administration of CdCl(2) (5mg/kg) for 4 weeks significantly induced renal damage which was evident from the increased levels of serum urea, uric acid and creatinine with a significant (p<0.05) decrease in creatinine clearance. Cd also significantly (p<0.05) decreased the levels of urea, uric acid and creatinine in urine. Cd-induced oxidative stress in kidney tissue was indicated by the increased levels of renal lipid peroxidation markers (thiobarbituric acid reactive substances and lipid hydroperoxides) and protein carbonyl content with a significant (p<0.05) decrease in non-enzymatic (total sulphydryl group, reduced glutathione, vitamin C and vitamin E) and enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR) and glucose 6-phosphate dehydrogenase (G6PD)). Moreover the kidneys of Cd-treated rats showed tubular necrosis, degeneration, dilation, desquamation, thickening of basement membrane and luminal cast formation. Quercetin treatment markedly attenuated the Cd-induced biochemical alterations in serum, urine and renal tissue. Quercetin also ameliorated the Cd-induced pathological changes when compared with Cd-alone-treated group. These data indicate that the natural dietary antioxidant quercetin might have protective effect against Cd-induced nephrotoxicity and oxidative stress in rats. SN - 1618-1433 UR - https://www.unboundmedicine.com/medline/citation/19615871/Quercetin_protects_against_oxidative_stress_related_renal_dysfunction_by_cadmium_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0940-2993(09)00202-4 DB - PRIME DP - Unbound Medicine ER -