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Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats.

Abstract

The aim of this study was to investigate the possible protective role of the dietary flavonoid quercetin on cadmium (Cd)-induced nephrotoxicity using biochemical and histopathological approaches. In experimental rats oral administration of CdCl(2) (5mg/kg) for 4 weeks significantly induced renal damage which was evident from the increased levels of serum urea, uric acid and creatinine with a significant (p<0.05) decrease in creatinine clearance. Cd also significantly (p<0.05) decreased the levels of urea, uric acid and creatinine in urine. Cd-induced oxidative stress in kidney tissue was indicated by the increased levels of renal lipid peroxidation markers (thiobarbituric acid reactive substances and lipid hydroperoxides) and protein carbonyl content with a significant (p<0.05) decrease in non-enzymatic (total sulphydryl group, reduced glutathione, vitamin C and vitamin E) and enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR) and glucose 6-phosphate dehydrogenase (G6PD)). Moreover the kidneys of Cd-treated rats showed tubular necrosis, degeneration, dilation, desquamation, thickening of basement membrane and luminal cast formation. Quercetin treatment markedly attenuated the Cd-induced biochemical alterations in serum, urine and renal tissue. Quercetin also ameliorated the Cd-induced pathological changes when compared with Cd-alone-treated group. These data indicate that the natural dietary antioxidant quercetin might have protective effect against Cd-induced nephrotoxicity and oxidative stress in rats.

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  • Authors+Show Affiliations

    ,

    Department of Zoology, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.

    Source

    MeSH

    Animals
    Antioxidants
    Cadmium Chloride
    Kidney Diseases
    Kidney Function Tests
    Lipid Peroxidation
    Male
    Oxidative Stress
    Quercetin
    Rats
    Rats, Wistar

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19615871

    Citation

    Renugadevi, J, and S Milton Prabu. "Quercetin Protects Against Oxidative Stress-related Renal Dysfunction By Cadmium in Rats." Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, vol. 62, no. 5, 2010, pp. 471-81.
    Renugadevi J, Prabu SM. Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Exp Toxicol Pathol. 2010;62(5):471-81.
    Renugadevi, J., & Prabu, S. M. (2010). Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 62(5), pp. 471-81. doi:10.1016/j.etp.2009.06.006.
    Renugadevi J, Prabu SM. Quercetin Protects Against Oxidative Stress-related Renal Dysfunction By Cadmium in Rats. Exp Toxicol Pathol. 2010;62(5):471-81. PubMed PMID: 19615871.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. AU - Renugadevi,J, AU - Prabu,S Milton, Y1 - 2009/07/16/ PY - 2009/04/08/received PY - 2009/05/16/revised PY - 2009/06/22/accepted PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2010/12/14/medline SP - 471 EP - 81 JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie JO - Exp. Toxicol. Pathol. VL - 62 IS - 5 N2 - The aim of this study was to investigate the possible protective role of the dietary flavonoid quercetin on cadmium (Cd)-induced nephrotoxicity using biochemical and histopathological approaches. In experimental rats oral administration of CdCl(2) (5mg/kg) for 4 weeks significantly induced renal damage which was evident from the increased levels of serum urea, uric acid and creatinine with a significant (p<0.05) decrease in creatinine clearance. Cd also significantly (p<0.05) decreased the levels of urea, uric acid and creatinine in urine. Cd-induced oxidative stress in kidney tissue was indicated by the increased levels of renal lipid peroxidation markers (thiobarbituric acid reactive substances and lipid hydroperoxides) and protein carbonyl content with a significant (p<0.05) decrease in non-enzymatic (total sulphydryl group, reduced glutathione, vitamin C and vitamin E) and enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR) and glucose 6-phosphate dehydrogenase (G6PD)). Moreover the kidneys of Cd-treated rats showed tubular necrosis, degeneration, dilation, desquamation, thickening of basement membrane and luminal cast formation. Quercetin treatment markedly attenuated the Cd-induced biochemical alterations in serum, urine and renal tissue. Quercetin also ameliorated the Cd-induced pathological changes when compared with Cd-alone-treated group. These data indicate that the natural dietary antioxidant quercetin might have protective effect against Cd-induced nephrotoxicity and oxidative stress in rats. SN - 1618-1433 UR - https://www.unboundmedicine.com/medline/citation/19615871/Quercetin_protects_against_oxidative_stress_related_renal_dysfunction_by_cadmium_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0940-2993(09)00202-4 DB - PRIME DP - Unbound Medicine ER -