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A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.

Abstract

BACKGROUND

Influenza vaccination is recommended for the elderly in many countries, but immune responses are weaker compared to younger adults.

OBJECTIVE

To investigate the impact of daily consumption of a probiotic dairy drink on the immune response to influenza vaccination in an elderly population of healthy volunteers over 70 years of age.

DESIGN

Two randomised, multicentre, double-blind, controlled studies were conducted during two vaccination seasons in 2005-2006 (pilot) and 2006-2007 (confirmatory). Eighty-six and 222 elderly volunteers consumed either a fermented dairy drink, containing the probiotic strain Lactobacillus casei DN-114 001 and yoghurt ferments (Actimel, or a non-fermented control dairy product twice daily for a period of 7 weeks (pilot) or 13 weeks (confirmatory). Vaccination occurred after 4 weeks of product consumption. Geometric mean antibody titres (GMT) against the 3 viral strains composing the vaccine (H1N1, H3N2, and B) were measured at several time intervals post-vaccination by haemagglutination inhibition test.

RESULTS

In the pilot study, the influenza-specific antibody titres increased after vaccination, being consistently higher in the probiotic product group compared to the control group under product consumption. Similarly, in the confirmatory study, titres against the B strain increased significantly more in the probiotic group than in the control group at 3, 6 and 9 weeks post-vaccination under product consumption (p=0.020). Significant differences in seroconversion between the groups by intended to treat analysis were still found 5 months after vaccination. Similar GMT results were observed for the H3N2 strain and H1N1 strain, confirming the results of the pilot study.

CONCLUSION

These studies demonstrate that daily consumption of this particular probiotic product increased relevant specific antibody responses to influenza vaccination in individuals of over 70 years of age and may therefore provide a health benefit in this population.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Centre Hospitalier de Bourg en Bresse, 01012 Bourg en Bresse, France.

    , , , ,

    Source

    Vaccine 27:41 2009 Sep 18 pg 5677-84

    MeSH

    Aged
    Aged, 80 and over
    Antibodies, Viral
    Dairy Products
    Double-Blind Method
    Female
    Hemagglutination Inhibition Tests
    Humans
    Immunologic Factors
    Influenza A Virus, H1N1 Subtype
    Influenza A Virus, H3N2 Subtype
    Influenza B virus
    Influenza Vaccines
    Lactobacillus casei
    Male
    Placebos
    Probiotics

    Pub Type(s)

    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19615959

    Citation

    Boge, Thierry, et al. "A Probiotic Fermented Dairy Drink Improves Antibody Response to Influenza Vaccination in the Elderly in Two Randomised Controlled Trials." Vaccine, vol. 27, no. 41, 2009, pp. 5677-84.
    Boge T, Rémigy M, Vaudaine S, et al. A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Vaccine. 2009;27(41):5677-84.
    Boge, T., Rémigy, M., Vaudaine, S., Tanguy, J., Bourdet-Sicard, R., & van der Werf, S. (2009). A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Vaccine, 27(41), pp. 5677-84. doi:10.1016/j.vaccine.2009.06.094.
    Boge T, et al. A Probiotic Fermented Dairy Drink Improves Antibody Response to Influenza Vaccination in the Elderly in Two Randomised Controlled Trials. Vaccine. 2009 Sep 18;27(41):5677-84. PubMed PMID: 19615959.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. AU - Boge,Thierry, AU - Rémigy,Michel, AU - Vaudaine,Sarah, AU - Tanguy,Jérôme, AU - Bourdet-Sicard,Raphaëlle, AU - van der Werf,Sylvie, Y1 - 2009/07/16/ PY - 2009/03/12/received PY - 2009/06/12/revised PY - 2009/06/29/accepted PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2009/10/17/medline SP - 5677 EP - 84 JF - Vaccine JO - Vaccine VL - 27 IS - 41 N2 - BACKGROUND: Influenza vaccination is recommended for the elderly in many countries, but immune responses are weaker compared to younger adults. OBJECTIVE: To investigate the impact of daily consumption of a probiotic dairy drink on the immune response to influenza vaccination in an elderly population of healthy volunteers over 70 years of age. DESIGN: Two randomised, multicentre, double-blind, controlled studies were conducted during two vaccination seasons in 2005-2006 (pilot) and 2006-2007 (confirmatory). Eighty-six and 222 elderly volunteers consumed either a fermented dairy drink, containing the probiotic strain Lactobacillus casei DN-114 001 and yoghurt ferments (Actimel, or a non-fermented control dairy product twice daily for a period of 7 weeks (pilot) or 13 weeks (confirmatory). Vaccination occurred after 4 weeks of product consumption. Geometric mean antibody titres (GMT) against the 3 viral strains composing the vaccine (H1N1, H3N2, and B) were measured at several time intervals post-vaccination by haemagglutination inhibition test. RESULTS: In the pilot study, the influenza-specific antibody titres increased after vaccination, being consistently higher in the probiotic product group compared to the control group under product consumption. Similarly, in the confirmatory study, titres against the B strain increased significantly more in the probiotic group than in the control group at 3, 6 and 9 weeks post-vaccination under product consumption (p=0.020). Significant differences in seroconversion between the groups by intended to treat analysis were still found 5 months after vaccination. Similar GMT results were observed for the H3N2 strain and H1N1 strain, confirming the results of the pilot study. CONCLUSION: These studies demonstrate that daily consumption of this particular probiotic product increased relevant specific antibody responses to influenza vaccination in individuals of over 70 years of age and may therefore provide a health benefit in this population. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/19615959/A_probiotic_fermented_dairy_drink_improves_antibody_response_to_influenza_vaccination_in_the_elderly_in_two_randomised_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(09)00978-5 DB - PRIME DP - Unbound Medicine ER -