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Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls.
Psychiatry Res. 2009 Sep 30; 173(3):163-9.PR

Abstract

Neuroimaging studies have revealed gray matter abnormalities in schizophrenia in various regions of the brain. It is, however, still unclear whether such abnormalities are already present in individuals at ultra-high risk (UHR) for transition into psychosis. We investigated this issue using voxel-based morphometry of structural magnetic resonance images (MRI) and compared UHR patients with first-episode patients with schizophrenia and healthy controls. Gray matter volume maps from high-resolution MR T1-weighted whole brain images were analyzed in a cross-sectional study in 30 UHR patients, 23 first-episode schizophrenic patients and 29 controls. UHR patients showed significantly lower gray matter volume in the cingulate gyrus bilaterally, in the right inferior frontal and right superior temporal gyrus, as well as in the left and right hippocampus in comparison to healthy subjects. First-episode patients with schizophrenia showed smaller gray matter volume in the cingulate cortex bilaterally, in the left orbitofrontal gyrus, in the right inferior frontal and superior temporal gyrus, in the right temporal pole, in the left and right hippocampus, in the left parahippocampus, left amygdala, and in the left fusiform gyrus compared to the UHR patients. This study provides further evidence that gray matter brain volume, especially in the anterior cingulate cortex, is already reduced in the prodromal state of schizophrenia.

Authors+Show Affiliations

Early Recognition and Therapy Centre for Psychoses Bochum (BoFit), Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr-University of Bochum, Alexandrinenstrasse 1, 44791, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19616415

Citation

Witthaus, Henning, et al. "Gray Matter Abnormalities in Subjects at Ultra-high Risk for Schizophrenia and First-episode Schizophrenic Patients Compared to Healthy Controls." Psychiatry Research, vol. 173, no. 3, 2009, pp. 163-9.
Witthaus H, Kaufmann C, Bohner G, et al. Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls. Psychiatry Res. 2009;173(3):163-9.
Witthaus, H., Kaufmann, C., Bohner, G., Ozgürdal, S., Gudlowski, Y., Gallinat, J., Ruhrmann, S., Brüne, M., Heinz, A., Klingebiel, R., & Juckel, G. (2009). Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls. Psychiatry Research, 173(3), 163-9. https://doi.org/10.1016/j.pscychresns.2008.08.002
Witthaus H, et al. Gray Matter Abnormalities in Subjects at Ultra-high Risk for Schizophrenia and First-episode Schizophrenic Patients Compared to Healthy Controls. Psychiatry Res. 2009 Sep 30;173(3):163-9. PubMed PMID: 19616415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls. AU - Witthaus,Henning, AU - Kaufmann,Christian, AU - Bohner,Georg, AU - Ozgürdal,Seza, AU - Gudlowski,Yehonala, AU - Gallinat,Jürgen, AU - Ruhrmann,Stephan, AU - Brüne,Martin, AU - Heinz,Andreas, AU - Klingebiel,Randolf, AU - Juckel,Georg, Y1 - 2009/07/17/ PY - 2007/06/26/received PY - 2008/05/02/revised PY - 2008/08/18/accepted PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2009/10/21/medline SP - 163 EP - 9 JF - Psychiatry research JO - Psychiatry Res VL - 173 IS - 3 N2 - Neuroimaging studies have revealed gray matter abnormalities in schizophrenia in various regions of the brain. It is, however, still unclear whether such abnormalities are already present in individuals at ultra-high risk (UHR) for transition into psychosis. We investigated this issue using voxel-based morphometry of structural magnetic resonance images (MRI) and compared UHR patients with first-episode patients with schizophrenia and healthy controls. Gray matter volume maps from high-resolution MR T1-weighted whole brain images were analyzed in a cross-sectional study in 30 UHR patients, 23 first-episode schizophrenic patients and 29 controls. UHR patients showed significantly lower gray matter volume in the cingulate gyrus bilaterally, in the right inferior frontal and right superior temporal gyrus, as well as in the left and right hippocampus in comparison to healthy subjects. First-episode patients with schizophrenia showed smaller gray matter volume in the cingulate cortex bilaterally, in the left orbitofrontal gyrus, in the right inferior frontal and superior temporal gyrus, in the right temporal pole, in the left and right hippocampus, in the left parahippocampus, left amygdala, and in the left fusiform gyrus compared to the UHR patients. This study provides further evidence that gray matter brain volume, especially in the anterior cingulate cortex, is already reduced in the prodromal state of schizophrenia. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/19616415/Gray_matter_abnormalities_in_subjects_at_ultra_high_risk_for_schizophrenia_and_first_episode_schizophrenic_patients_compared_to_healthy_controls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4927(08)00125-X DB - PRIME DP - Unbound Medicine ER -