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Effect of intradialytic intravenous administration of omega-3 fatty acids on nutritional status and inflammatory response in hemodialysis patients: a pilot study.
J Ren Nutr. 2009 Nov; 19(6):487-93.JR

Abstract

OBJECTIVE

Because omega-3 polyunsaturated fatty acids (PUFAs) may have anti-inflammatory properties, we tested the hypothesis that intradialytic, intravenous omega-3 PUFA treatment, combined with dietary supplementation, can modify the inflammatory response to dialysis, and influence the nutritional status of hemodialysis (HD) patients.

METHODS

Twenty HD patients with serum albumin at <39g/L received 100mL of 10% omega-3 PUFA emulsion during 11 consecutive HD sessions. Body mass index (BMI), serum albumin, transferrin, and lipids were measured before and after treatment. Serum interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) levels were determined before and after the HD session at baseline and after 4 weeks of treatment.

RESULTS

No adverse events were evident during the study. There were no significant changes in BMI, serum albumin, transferin, total and low-density lipoprotein cholesterol, and triglycerides. Predialysis hsCRP and IL-6 did not change. There was a significant increase in hsCRP (P=.01) and a tendency of IL-6 concentration to increase during the HD session before treatment (P=.067). In contrast, neither hsCRP (P=.21) nor IL-6 (P=.26) changed during the final HD session. Neither urea reduction ratio nor Kt/V changed significantly during the study, but the normalized protein catabolic ratio increased after treatment (P=.003).

CONCLUSIONS

Short-term parenteral administration of omega-3 PUFA is safe and well-tolerated by HD patients. The intervention does not significantly influence markers of inflammation or change the nutritional status of chronic HD patients, but it may attenuate the inflammatory response to HD sessions.

Authors+Show Affiliations

Department of Nephrology, Hypertension, and Kidney Transplantation, Medical University of Łódź, Łódź 91-156, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19616450

Citation

Szklarek-Kubicka, Magdalena, et al. "Effect of Intradialytic Intravenous Administration of Omega-3 Fatty Acids On Nutritional Status and Inflammatory Response in Hemodialysis Patients: a Pilot Study." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 19, no. 6, 2009, pp. 487-93.
Szklarek-Kubicka M, Fijałkowska-Morawska J, Zaremba-Drobnik D, et al. Effect of intradialytic intravenous administration of omega-3 fatty acids on nutritional status and inflammatory response in hemodialysis patients: a pilot study. J Ren Nutr. 2009;19(6):487-93.
Szklarek-Kubicka, M., Fijałkowska-Morawska, J., Zaremba-Drobnik, D., Uciński, A., Czekalski, S., & Nowicki, M. (2009). Effect of intradialytic intravenous administration of omega-3 fatty acids on nutritional status and inflammatory response in hemodialysis patients: a pilot study. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 19(6), 487-93. https://doi.org/10.1053/j.jrn.2009.05.007
Szklarek-Kubicka M, et al. Effect of Intradialytic Intravenous Administration of Omega-3 Fatty Acids On Nutritional Status and Inflammatory Response in Hemodialysis Patients: a Pilot Study. J Ren Nutr. 2009;19(6):487-93. PubMed PMID: 19616450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of intradialytic intravenous administration of omega-3 fatty acids on nutritional status and inflammatory response in hemodialysis patients: a pilot study. AU - Szklarek-Kubicka,Magdalena, AU - Fijałkowska-Morawska,Jolanta, AU - Zaremba-Drobnik,Danuta, AU - Uciński,Andrzej, AU - Czekalski,Stanisław, AU - Nowicki,Michał, Y1 - 2009/07/17/ PY - 2008/11/08/received PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2010/1/21/medline SP - 487 EP - 93 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 19 IS - 6 N2 - OBJECTIVE: Because omega-3 polyunsaturated fatty acids (PUFAs) may have anti-inflammatory properties, we tested the hypothesis that intradialytic, intravenous omega-3 PUFA treatment, combined with dietary supplementation, can modify the inflammatory response to dialysis, and influence the nutritional status of hemodialysis (HD) patients. METHODS: Twenty HD patients with serum albumin at <39g/L received 100mL of 10% omega-3 PUFA emulsion during 11 consecutive HD sessions. Body mass index (BMI), serum albumin, transferrin, and lipids were measured before and after treatment. Serum interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) levels were determined before and after the HD session at baseline and after 4 weeks of treatment. RESULTS: No adverse events were evident during the study. There were no significant changes in BMI, serum albumin, transferin, total and low-density lipoprotein cholesterol, and triglycerides. Predialysis hsCRP and IL-6 did not change. There was a significant increase in hsCRP (P=.01) and a tendency of IL-6 concentration to increase during the HD session before treatment (P=.067). In contrast, neither hsCRP (P=.21) nor IL-6 (P=.26) changed during the final HD session. Neither urea reduction ratio nor Kt/V changed significantly during the study, but the normalized protein catabolic ratio increased after treatment (P=.003). CONCLUSIONS: Short-term parenteral administration of omega-3 PUFA is safe and well-tolerated by HD patients. The intervention does not significantly influence markers of inflammation or change the nutritional status of chronic HD patients, but it may attenuate the inflammatory response to HD sessions. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/19616450/Effect_of_intradialytic_intravenous_administration_of_omega_3_fatty_acids_on_nutritional_status_and_inflammatory_response_in_hemodialysis_patients:_a_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(09)00139-3 DB - PRIME DP - Unbound Medicine ER -