Tags

Type your tag names separated by a space and hit enter

MDMA-induced serotonergic neurotoxicity enhances aggressiveness in low- but not high-aggressive rats.
Eur J Pharmacol. 2009 Sep 15; 618(1-3):22-7.EJ

Abstract

Ecstasy or 3,4-methylenedioxymethamphetamine (MDMA) is a frequently (ab)used recreational drug for its acute euphoric effects but on the long-term may cause neurotoxic damage to serotonin (5-hydroxytryptamine; 5-HT) nerve endings in the brain. Since decreased brain 5-HT function has been strongly associated with several impulse control disorders like hostility and violent aggression, ecstasy users might be at risk developing this form of psychopathology. The present study examined the ability of a MDMA administration protocol (3 x 6 mg/kg, with 3h intervals at 25 degrees C ambient temperature), that previously was shown to partially deplete brain serotonin levels, to increase offensive aggressive behavior in male Wild-type Groningen (WTG) rats. This rat strain is known for its broad individual variation in offensive aggression. Resident-intruder aggression was assessed 5 days before and 23 days after MDMA administration. On day 28, MDMA neurotoxicity to 5-HT nerve terminals was assessed by quantification of serotonin reuptake transporter (SERT) immuno-positive axons in defined brain regions. Based on their expressed aggression level in the initial aggression test, rats were divided into low (<10% aggression), high (>50% aggression) or medium aggressive (10-50%) groups. The study demonstrated that MDMA treatment increased aggressiveness in only low aggressive rats and not in medium and high aggressive animals. Irrespective of their initial aggressiveness, MDMA significantly reduced the number of SERT-positive axons in all animals. In conclusion, vulnerability for increased aggression long after a single MDMA treatment is dependent on the individual's trait aggressiveness but not on the degree of MDMA-induced serotonergic neurotoxicity.

Authors+Show Affiliations

Department of Behavioral Physiology, Biological Center, University of Groningen, Haren, The Netherlands. A.E.Wallinga@rug.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19616536

Citation

Wallinga, Alinde E., et al. "MDMA-induced Serotonergic Neurotoxicity Enhances Aggressiveness in Low- but Not High-aggressive Rats." European Journal of Pharmacology, vol. 618, no. 1-3, 2009, pp. 22-7.
Wallinga AE, ten Voorde AM, de Boer SF, et al. MDMA-induced serotonergic neurotoxicity enhances aggressiveness in low- but not high-aggressive rats. Eur J Pharmacol. 2009;618(1-3):22-7.
Wallinga, A. E., ten Voorde, A. M., de Boer, S. F., Koolhaas, J. M., & Buwalda, B. (2009). MDMA-induced serotonergic neurotoxicity enhances aggressiveness in low- but not high-aggressive rats. European Journal of Pharmacology, 618(1-3), 22-7. https://doi.org/10.1016/j.ejphar.2009.07.006
Wallinga AE, et al. MDMA-induced Serotonergic Neurotoxicity Enhances Aggressiveness in Low- but Not High-aggressive Rats. Eur J Pharmacol. 2009 Sep 15;618(1-3):22-7. PubMed PMID: 19616536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MDMA-induced serotonergic neurotoxicity enhances aggressiveness in low- but not high-aggressive rats. AU - Wallinga,Alinde E, AU - ten Voorde,Anna M, AU - de Boer,Sietse F, AU - Koolhaas,Jaap M, AU - Buwalda,Bauke, Y1 - 2009/07/17/ PY - 2008/10/29/received PY - 2009/06/26/revised PY - 2009/07/09/accepted PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2010/1/6/medline SP - 22 EP - 7 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 618 IS - 1-3 N2 - Ecstasy or 3,4-methylenedioxymethamphetamine (MDMA) is a frequently (ab)used recreational drug for its acute euphoric effects but on the long-term may cause neurotoxic damage to serotonin (5-hydroxytryptamine; 5-HT) nerve endings in the brain. Since decreased brain 5-HT function has been strongly associated with several impulse control disorders like hostility and violent aggression, ecstasy users might be at risk developing this form of psychopathology. The present study examined the ability of a MDMA administration protocol (3 x 6 mg/kg, with 3h intervals at 25 degrees C ambient temperature), that previously was shown to partially deplete brain serotonin levels, to increase offensive aggressive behavior in male Wild-type Groningen (WTG) rats. This rat strain is known for its broad individual variation in offensive aggression. Resident-intruder aggression was assessed 5 days before and 23 days after MDMA administration. On day 28, MDMA neurotoxicity to 5-HT nerve terminals was assessed by quantification of serotonin reuptake transporter (SERT) immuno-positive axons in defined brain regions. Based on their expressed aggression level in the initial aggression test, rats were divided into low (<10% aggression), high (>50% aggression) or medium aggressive (10-50%) groups. The study demonstrated that MDMA treatment increased aggressiveness in only low aggressive rats and not in medium and high aggressive animals. Irrespective of their initial aggressiveness, MDMA significantly reduced the number of SERT-positive axons in all animals. In conclusion, vulnerability for increased aggression long after a single MDMA treatment is dependent on the individual's trait aggressiveness but not on the degree of MDMA-induced serotonergic neurotoxicity. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/19616536/MDMA_induced_serotonergic_neurotoxicity_enhances_aggressiveness_in_low__but_not_high_aggressive_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(09)00598-6 DB - PRIME DP - Unbound Medicine ER -