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Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: a novel nitric oxide mechanism.
Food Chem Toxicol. 2009 Oct; 47(10):2522-30.FC

Abstract

Huntington's disease is a neurodegenerative disorder characterized by symptoms like chorea and dementia. There is no exact therapeutic agent available to manage and cure this disease. 3-Nitropropionic acid, a neurotoxin causes gait and memory impairment which leads to oxidative damage and upsets glutathione defense in animals. 3-NP model is a useful tool to develop suitable therapeutic agent in the treatment of Huntington's disease. Present study compares the effects of lycopene and epigallocatechin-3-gallate (EGCG) on memory impairment and disturbs glutathione system against 3-NP treatment. 3-NP treatment significantly impaired memory as assessed in Morris water maze and elevated plus maze tasks. On the 15 day, the levels of reduced glutathione, total glutathione and glutathione-S-transferase were also significantly decreased in the striatum, hippocampus and cortex areas of the brain. The treatment with lycopene (2.5, 5 and 10mg/kg) and EGCG (10, 20 and 40 mg/kg) significantly improved memory and restored glutathione system functioning. Further, L-arginine and L-NAME pretreatment with the sub effective dose of lycopene (5mg/kg) and EGCG (20mg/kg) reversed and potentiate their protective effects respectively. In conclusion, lycopene and EGCG could be used to mange 3-NP induced behavioral and biochemical alterations by involving nitric oxide pathways.

Authors+Show Affiliations

Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160 014, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19616597

Citation

Kumar, Puneet, and Anil Kumar. "Effect of Lycopene and Epigallocatechin-3-gallate Against 3-nitropropionic Acid Induced Cognitive Dysfunction and Glutathione Depletion in Rat: a Novel Nitric Oxide Mechanism." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 10, 2009, pp. 2522-30.
Kumar P, Kumar A. Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: a novel nitric oxide mechanism. Food Chem Toxicol. 2009;47(10):2522-30.
Kumar, P., & Kumar, A. (2009). Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: a novel nitric oxide mechanism. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(10), 2522-30. https://doi.org/10.1016/j.fct.2009.07.011
Kumar P, Kumar A. Effect of Lycopene and Epigallocatechin-3-gallate Against 3-nitropropionic Acid Induced Cognitive Dysfunction and Glutathione Depletion in Rat: a Novel Nitric Oxide Mechanism. Food Chem Toxicol. 2009;47(10):2522-30. PubMed PMID: 19616597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: a novel nitric oxide mechanism. AU - Kumar,Puneet, AU - Kumar,Anil, Y1 - 2009/07/17/ PY - 2009/05/07/received PY - 2009/07/07/revised PY - 2009/07/10/accepted PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2009/12/16/medline SP - 2522 EP - 30 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 10 N2 - Huntington's disease is a neurodegenerative disorder characterized by symptoms like chorea and dementia. There is no exact therapeutic agent available to manage and cure this disease. 3-Nitropropionic acid, a neurotoxin causes gait and memory impairment which leads to oxidative damage and upsets glutathione defense in animals. 3-NP model is a useful tool to develop suitable therapeutic agent in the treatment of Huntington's disease. Present study compares the effects of lycopene and epigallocatechin-3-gallate (EGCG) on memory impairment and disturbs glutathione system against 3-NP treatment. 3-NP treatment significantly impaired memory as assessed in Morris water maze and elevated plus maze tasks. On the 15 day, the levels of reduced glutathione, total glutathione and glutathione-S-transferase were also significantly decreased in the striatum, hippocampus and cortex areas of the brain. The treatment with lycopene (2.5, 5 and 10mg/kg) and EGCG (10, 20 and 40 mg/kg) significantly improved memory and restored glutathione system functioning. Further, L-arginine and L-NAME pretreatment with the sub effective dose of lycopene (5mg/kg) and EGCG (20mg/kg) reversed and potentiate their protective effects respectively. In conclusion, lycopene and EGCG could be used to mange 3-NP induced behavioral and biochemical alterations by involving nitric oxide pathways. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19616597/Effect_of_lycopene_and_epigallocatechin_3_gallate_against_3_nitropropionic_acid_induced_cognitive_dysfunction_and_glutathione_depletion_in_rat:_a_novel_nitric_oxide_mechanism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00338-X DB - PRIME DP - Unbound Medicine ER -