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Lack of prompt expansion of cytomegalovirus pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia and DNAemia during pre-emptive therapy in allogeneic hematopoietic stem cell transplant recipients.
Bone Marrow Transplant. 2010 Mar; 45(3):543-9.BM

Abstract

Rising levels of cytomegalovirus (CMV) DNAemia and/or pp65 antigenemia have been observed during pre-emptive ganciclovir therapy in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT). We assessed the incidence of this event in our series, and investigated whether its occurrence was associated with an impairment in the CMV-specific T-cell response. A total of 36 allo-SCT recipients experienced one or more episodes of active CMV infection (n=68) that were pre-emptively treated with val(ganciclovir). Rising levels of antigenemia and DNAemia, and an isolated increase in antigenemia, were observed in 39.7 and 2.9% of all episodes, respectively. Receipt of corticosteroids was associated with rising levels of antigenemia and DNAemia. Median increases of 12- and 6.8-fold of IFNgamma CD8(+) T and IFNgamma CD4(+) T cells, respectively, were observed at a median of 16.5 days after initiation of therapy in episodes with decreasing levels in antigenemia and DNAemia. In contrast, the numbers of both T-cell subsets at a median of 13.5 days after initiation of therapy did not differ significantly from those of pre-treatment samples in episodes with rising levels of antigenemia and DNAemia. Lack of prompt expansion of CMV pp65 and IE-1-specific IFNgamma CD8(+) and CD4(+) T cells is associated with rising levels in antigenemia and DNAemia during pre-emptive therapy.

Authors+Show Affiliations

Microbiology Service, Hospital Clínico Universitario, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19617905

Citation

Tormo, N, et al. "Lack of Prompt Expansion of Cytomegalovirus Pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T Cells Is Associated With Rising Levels of Pp65 Antigenemia and DNAemia During Pre-emptive Therapy in Allogeneic Hematopoietic Stem Cell Transplant Recipients." Bone Marrow Transplantation, vol. 45, no. 3, 2010, pp. 543-9.
Tormo N, Solano C, Benet I, et al. Lack of prompt expansion of cytomegalovirus pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia and DNAemia during pre-emptive therapy in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2010;45(3):543-9.
Tormo, N., Solano, C., Benet, I., Clari, M. A., Nieto, J., de la Cámara, R., López, J., López-Aldeguer, N., Hernández-Boluda, J. C., Remigia, M. J., Garcia-Noblejas, A., Gimeno, C., & Navarro, D. (2010). Lack of prompt expansion of cytomegalovirus pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia and DNAemia during pre-emptive therapy in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplantation, 45(3), 543-9. https://doi.org/10.1038/bmt.2009.172
Tormo N, et al. Lack of Prompt Expansion of Cytomegalovirus Pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T Cells Is Associated With Rising Levels of Pp65 Antigenemia and DNAemia During Pre-emptive Therapy in Allogeneic Hematopoietic Stem Cell Transplant Recipients. Bone Marrow Transplant. 2010;45(3):543-9. PubMed PMID: 19617905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of prompt expansion of cytomegalovirus pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia and DNAemia during pre-emptive therapy in allogeneic hematopoietic stem cell transplant recipients. AU - Tormo,N, AU - Solano,C, AU - Benet,I, AU - Clari,M A, AU - Nieto,J, AU - de la Cámara,R, AU - López,J, AU - López-Aldeguer,N, AU - Hernández-Boluda,J C, AU - Remigia,M J, AU - Garcia-Noblejas,A, AU - Gimeno,C, AU - Navarro,D, Y1 - 2009/07/20/ PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2010/6/4/medline SP - 543 EP - 9 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 45 IS - 3 N2 - Rising levels of cytomegalovirus (CMV) DNAemia and/or pp65 antigenemia have been observed during pre-emptive ganciclovir therapy in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT). We assessed the incidence of this event in our series, and investigated whether its occurrence was associated with an impairment in the CMV-specific T-cell response. A total of 36 allo-SCT recipients experienced one or more episodes of active CMV infection (n=68) that were pre-emptively treated with val(ganciclovir). Rising levels of antigenemia and DNAemia, and an isolated increase in antigenemia, were observed in 39.7 and 2.9% of all episodes, respectively. Receipt of corticosteroids was associated with rising levels of antigenemia and DNAemia. Median increases of 12- and 6.8-fold of IFNgamma CD8(+) T and IFNgamma CD4(+) T cells, respectively, were observed at a median of 16.5 days after initiation of therapy in episodes with decreasing levels in antigenemia and DNAemia. In contrast, the numbers of both T-cell subsets at a median of 13.5 days after initiation of therapy did not differ significantly from those of pre-treatment samples in episodes with rising levels of antigenemia and DNAemia. Lack of prompt expansion of CMV pp65 and IE-1-specific IFNgamma CD8(+) and CD4(+) T cells is associated with rising levels in antigenemia and DNAemia during pre-emptive therapy. SN - 1476-5365 UR - https://www.unboundmedicine.com/medline/citation/19617905/Lack_of_prompt_expansion_of_cytomegalovirus_pp65_and_IE_1_specific_IFNgamma_CD8+_and_CD4+_T_cells_is_associated_with_rising_levels_of_pp65_antigenemia_and_DNAemia_during_pre_emptive_therapy_in_allogeneic_hematopoietic_stem_cell_transplant_recipients_ L2 - https://doi.org/10.1038/bmt.2009.172 DB - PRIME DP - Unbound Medicine ER -