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Factors associated with insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes.
Exp Clin Endocrinol Diabetes. 2009 Nov; 117(10):600-4.EC

Abstract

OBJECTIVE

To investigate the changes of insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes mellitus (FHD) and analyze its related factors.

METHODS

The study included 159 adolescents aged 13-15 years. Anthropometric- measurements, including height, weight and waist. Blood samples were collected and fasting plasma glucose (FPG), serum lipids, true insulin (TI) and fasting plasma ghrelin were assayed. They were divided into four groups according to body mass index (BMI) and FHD: 40 non-obese adolescents without FHD in group A; 40 overweight and obese adolescents without FHD in group B; 40 non-obese adolescents with FHD in group C; 39 overweight and obese adolescents with FHD in group D.

RESULTS

Group B, C and D had significantly higher levels of HOMA-IR and HOMA-beta index than group A, especially Group D (p<0.01). Group C and D had significantly higher levels of FPG and lower levels of ghrelin than group A (p<0.01). HOMA-IR showed positive correlation with BMI (r=0.445), waist (r=0.435), waist-to-height ratio (WHtR)(r=0.471) (p<0.01). Ghrelin showed negative correlation with FPG (r=-0.339), TI (r=-0.237) and HOMA-IR (r=-0.269) (p<0.01). In multiple linear regression analysis, WHtR (beta=4.925, p=0.000) and FHD (beta=0.492, p=0.000) were significant independent predictors for HOMA-IR. FHD (beta=-289.856, p=0.000) and FPG (beta=-228.203, p=0.001) were significant independent predictors for ghrelin.

CONCLUSION

This study showed that the subjects with FHD and obesity who are predisposed to diabetes have insulin resistance in adolescent stage. The lower ghrelin levels in subjects with FHD may be the result of elevated FPG.

Authors+Show Affiliations

The First Hospital of Qinhuangdao, Endocrionology, Qinhuangado, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19618346

Citation

Liu, Bo-wei, et al. "Factors Associated With Insulin Resistance and Fasting Plasma Ghrelin Levels in Adolescents With Obesity and Family History of Type 2 Diabetes." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 117, no. 10, 2009, pp. 600-4.
Liu BW, Lu Q, Ma CM, et al. Factors associated with insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes. Exp Clin Endocrinol Diabetes. 2009;117(10):600-4.
Liu, B. W., Lu, Q., Ma, C. M., Wang, S. Y., Lou, D. H., Lou, X. L., & Yin, F. Z. (2009). Factors associated with insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 117(10), 600-4. https://doi.org/10.1055/s-0029-1225353
Liu BW, et al. Factors Associated With Insulin Resistance and Fasting Plasma Ghrelin Levels in Adolescents With Obesity and Family History of Type 2 Diabetes. Exp Clin Endocrinol Diabetes. 2009;117(10):600-4. PubMed PMID: 19618346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes. AU - Liu,Bo-wei, AU - Lu,Quiang, AU - Ma,Chun-ming, AU - Wang,Shu-yi, AU - Lou,Dong-hui, AU - Lou,Xiao-li, AU - Yin,Fu-zai, Y1 - 2009/07/17/ PY - 2009/7/21/entrez PY - 2009/7/21/pubmed PY - 2010/1/27/medline SP - 600 EP - 4 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp. Clin. Endocrinol. Diabetes VL - 117 IS - 10 N2 - OBJECTIVE: To investigate the changes of insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes mellitus (FHD) and analyze its related factors. METHODS: The study included 159 adolescents aged 13-15 years. Anthropometric- measurements, including height, weight and waist. Blood samples were collected and fasting plasma glucose (FPG), serum lipids, true insulin (TI) and fasting plasma ghrelin were assayed. They were divided into four groups according to body mass index (BMI) and FHD: 40 non-obese adolescents without FHD in group A; 40 overweight and obese adolescents without FHD in group B; 40 non-obese adolescents with FHD in group C; 39 overweight and obese adolescents with FHD in group D. RESULTS: Group B, C and D had significantly higher levels of HOMA-IR and HOMA-beta index than group A, especially Group D (p<0.01). Group C and D had significantly higher levels of FPG and lower levels of ghrelin than group A (p<0.01). HOMA-IR showed positive correlation with BMI (r=0.445), waist (r=0.435), waist-to-height ratio (WHtR)(r=0.471) (p<0.01). Ghrelin showed negative correlation with FPG (r=-0.339), TI (r=-0.237) and HOMA-IR (r=-0.269) (p<0.01). In multiple linear regression analysis, WHtR (beta=4.925, p=0.000) and FHD (beta=0.492, p=0.000) were significant independent predictors for HOMA-IR. FHD (beta=-289.856, p=0.000) and FPG (beta=-228.203, p=0.001) were significant independent predictors for ghrelin. CONCLUSION: This study showed that the subjects with FHD and obesity who are predisposed to diabetes have insulin resistance in adolescent stage. The lower ghrelin levels in subjects with FHD may be the result of elevated FPG. SN - 1439-3646 UR - https://www.unboundmedicine.com/medline/citation/19618346/Factors_associated_with_insulin_resistance_and_fasting_plasma_ghrelin_levels_in_adolescents_with_obesity_and_family_history_of_type_2_diabetes_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1225353 DB - PRIME DP - Unbound Medicine ER -