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Molecular epidemiology of H5N1 avian influenza.
Rev Sci Tech. 2009 Apr; 28(1):39-47.RS

Abstract

The highly pathogenic Asian H5N1 influenza virus that was first detected in Guangdong in the People's Republic of China (China) in 1996 is unique in having spread to humans and other mammalian species. To date, this virus has not consistently transmitted between any mammalian species but the continued spread and evolution of these viruses in domestic poultry across Eurasia presents a continuing pandemic threat. These viruses have caused devastation in domestic poultry and have killed over 60% of infected humans. The H5N1 viruses are unique in having evolved into multiple clades and subclades by reassortment with other influenza viruses in the epicentre of southern China, and accumulation of point mutations has resulted in antigenic differences between the clades. Three waves of spread have occurred, wave one to East Asia and Southeast Asia, wave two through Qinghai Lake, China, to Europe, India and Africa, and wave three to Southeast Asia again. This paper deals with the molecular epidemiology of the evolution of the multiplicity of H5N1 clades. The continuing evolution of these H5N1 viruses and the possible establishment of secondary epicentres in Indonesia, Egypt and Nigeria present a continuing threat to poultry and people globally.

Authors+Show Affiliations

State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19618617

Citation

Guan, Y, et al. "Molecular Epidemiology of H5N1 Avian Influenza." Revue Scientifique Et Technique (International Office of Epizootics), vol. 28, no. 1, 2009, pp. 39-47.
Guan Y, Smith GJ, Webby R, et al. Molecular epidemiology of H5N1 avian influenza. Rev - Off Int Epizoot. 2009;28(1):39-47.
Guan, Y., Smith, G. J., Webby, R., & Webster, R. G. (2009). Molecular epidemiology of H5N1 avian influenza. Revue Scientifique Et Technique (International Office of Epizootics), 28(1), 39-47.
Guan Y, et al. Molecular Epidemiology of H5N1 Avian Influenza. Rev - Off Int Epizoot. 2009;28(1):39-47. PubMed PMID: 19618617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular epidemiology of H5N1 avian influenza. AU - Guan,Y, AU - Smith,G J D, AU - Webby,R, AU - Webster,R G, PY - 2009/7/22/entrez PY - 2009/7/22/pubmed PY - 2009/8/19/medline SP - 39 EP - 47 JF - Revue scientifique et technique (International Office of Epizootics) JO - Rev. - Off. Int. Epizoot. VL - 28 IS - 1 N2 - The highly pathogenic Asian H5N1 influenza virus that was first detected in Guangdong in the People's Republic of China (China) in 1996 is unique in having spread to humans and other mammalian species. To date, this virus has not consistently transmitted between any mammalian species but the continued spread and evolution of these viruses in domestic poultry across Eurasia presents a continuing pandemic threat. These viruses have caused devastation in domestic poultry and have killed over 60% of infected humans. The H5N1 viruses are unique in having evolved into multiple clades and subclades by reassortment with other influenza viruses in the epicentre of southern China, and accumulation of point mutations has resulted in antigenic differences between the clades. Three waves of spread have occurred, wave one to East Asia and Southeast Asia, wave two through Qinghai Lake, China, to Europe, India and Africa, and wave three to Southeast Asia again. This paper deals with the molecular epidemiology of the evolution of the multiplicity of H5N1 clades. The continuing evolution of these H5N1 viruses and the possible establishment of secondary epicentres in Indonesia, Egypt and Nigeria present a continuing threat to poultry and people globally. SN - 0253-1933 UR - https://www.unboundmedicine.com/medline/citation/19618617/Molecular_epidemiology_of_H5N1_avian_influenza_ L2 - http://dx.doi.org/10.20506/rst.28.1.1868 DB - PRIME DP - Unbound Medicine ER -