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Magnetic marker monitoring: high resolution real-time tracking of oral solid dosage forms in the gastrointestinal tract.
Eur J Pharm Biopharm. 2010 Jan; 74(1):93-101.EJ

Abstract

Knowledge about the performance of dosage forms in the gastrointestinal tract is essential for the development of new oral delivery systems, as well as for the choice of the optimal formulation technology. Magnetic Marker Monitoring (MMM) is an imaging technology for the investigation of the behaviour of solid oral dosage forms within the gastrointestinal tract, which is based on the labelling of solid dosage forms as a magnetic dipole and determination of the location, orientation and strength of the dipole after oral administration using measurement equipment and localization methods that are established in biomagnetism. MMM enables the investigation of the performance of solid dosage forms in the gastrointestinal tract with a temporal resolution in the range of a few milliseconds and a spatial resolution in 3D in the range of some millimetres. Thereby, MMM provides real-time tracking of dosage forms in the gastrointestinal tract. MMM is also suitable for the determination of dosage form disintegration and for quantitative measurement of in vivo drug release in case of appropriate extended release dosage forms like hydrogel-forming matrix tablets. The combination of MMM with pharmacokinetic measurements (pharmacomagnetography) enables the determination of in vitro-in vivo correlations (IVIC) and the delineation of absorption sites in the gastrointestinal tract.

Authors+Show Affiliations

Department of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, D-17487 Greifswald, Germany. werner.weitschies@uni-greifswald.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19619649

Citation

Weitschies, Werner, et al. "Magnetic Marker Monitoring: High Resolution Real-time Tracking of Oral Solid Dosage Forms in the Gastrointestinal Tract." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 74, no. 1, 2010, pp. 93-101.
Weitschies W, Blume H, Mönnikes H. Magnetic marker monitoring: high resolution real-time tracking of oral solid dosage forms in the gastrointestinal tract. Eur J Pharm Biopharm. 2010;74(1):93-101.
Weitschies, W., Blume, H., & Mönnikes, H. (2010). Magnetic marker monitoring: high resolution real-time tracking of oral solid dosage forms in the gastrointestinal tract. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 74(1), 93-101. https://doi.org/10.1016/j.ejpb.2009.07.007
Weitschies W, Blume H, Mönnikes H. Magnetic Marker Monitoring: High Resolution Real-time Tracking of Oral Solid Dosage Forms in the Gastrointestinal Tract. Eur J Pharm Biopharm. 2010;74(1):93-101. PubMed PMID: 19619649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic marker monitoring: high resolution real-time tracking of oral solid dosage forms in the gastrointestinal tract. AU - Weitschies,Werner, AU - Blume,Henning, AU - Mönnikes,Hubert, Y1 - 2009/07/18/ PY - 2009/04/23/received PY - 2009/07/08/revised PY - 2009/07/14/accepted PY - 2009/7/22/entrez PY - 2009/7/22/pubmed PY - 2010/4/7/medline SP - 93 EP - 101 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 74 IS - 1 N2 - Knowledge about the performance of dosage forms in the gastrointestinal tract is essential for the development of new oral delivery systems, as well as for the choice of the optimal formulation technology. Magnetic Marker Monitoring (MMM) is an imaging technology for the investigation of the behaviour of solid oral dosage forms within the gastrointestinal tract, which is based on the labelling of solid dosage forms as a magnetic dipole and determination of the location, orientation and strength of the dipole after oral administration using measurement equipment and localization methods that are established in biomagnetism. MMM enables the investigation of the performance of solid dosage forms in the gastrointestinal tract with a temporal resolution in the range of a few milliseconds and a spatial resolution in 3D in the range of some millimetres. Thereby, MMM provides real-time tracking of dosage forms in the gastrointestinal tract. MMM is also suitable for the determination of dosage form disintegration and for quantitative measurement of in vivo drug release in case of appropriate extended release dosage forms like hydrogel-forming matrix tablets. The combination of MMM with pharmacokinetic measurements (pharmacomagnetography) enables the determination of in vitro-in vivo correlations (IVIC) and the delineation of absorption sites in the gastrointestinal tract. SN - 1873-3441 UR - https://www.unboundmedicine.com/medline/citation/19619649/Magnetic_marker_monitoring:_high_resolution_real_time_tracking_of_oral_solid_dosage_forms_in_the_gastrointestinal_tract_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(09)00215-X DB - PRIME DP - Unbound Medicine ER -