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Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release.
Acta Biomater. 2010 Feb; 6(2):486-93.AB

Abstract

Poly(2-hydroxyethyl methacrylate) hydrogels containing beta-cyclodextrin (pHEMA/beta-CD) have been investigated as a platform for sustained release of ophthalmic drugs. First of all, pHEMA/beta-CD hydrogel membranes and contact lenses were prepared by photopolymerization of HEMA, mono-methacrylated beta-CD (mono-MA-beta-CD) and trimethylolpropane trimethacrylate using a cast molding process. The hydrogels were characterized by Fourier transform infrared spectroscopy, equilibrium swelling ratio (ESR) and tensile tester. The results showed that the incorporation of beta-CD in the hydrogels increased the ESR and tensile strength. Then, puerarin was used as a model to evaluate drug loading and in vitro and in vivo release behavior of the pHEMA/beta-CD hydrogels. It was revealed that puerarin loading and in vitro release rate were dependent on beta-CD content in the pHEMA/beta-CD hydrogels. In rabbit eyes the pHEMA/beta-CD hydrogel contact lenses exhibited longer mean residence times (MRT(F)) of puerarin in tear fluid than that of pHEMA contact lenses and 1% puerarin eye drops. The puerarin concentration in the aqueous humor of rabbit reached a maximum of 0.81microg ml(-1) after wearing the pHEMA/beta-CD contact lens, which had been presoaked in 0.802mg ml(-1) puerarin solution for 4.81h. Also, the pHEMA/beta-CD contact lenses had a higher drug bioavailability in aqueous humor than puerarin eye drops. The data demonstrate that pHEMA/beta-CD hydrogel contact lenses can effectively deliver puerarin through the cornea.

Authors+Show Affiliations

Biomaterials and Drug Delivery Laboratories, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19619677

Citation

Xu, Jinku, et al. "Cyclodextrin-containing Hydrogels for Contact Lenses as a Platform for Drug Incorporation and Release." Acta Biomaterialia, vol. 6, no. 2, 2010, pp. 486-93.
Xu J, Li X, Sun F. Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release. Acta Biomater. 2010;6(2):486-93.
Xu, J., Li, X., & Sun, F. (2010). Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release. Acta Biomaterialia, 6(2), 486-93. https://doi.org/10.1016/j.actbio.2009.07.021
Xu J, Li X, Sun F. Cyclodextrin-containing Hydrogels for Contact Lenses as a Platform for Drug Incorporation and Release. Acta Biomater. 2010;6(2):486-93. PubMed PMID: 19619677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release. AU - Xu,Jinku, AU - Li,Xinsong, AU - Sun,Fuqian, Y1 - 2009/07/18/ PY - 2009/02/15/received PY - 2009/05/31/revised PY - 2009/07/15/accepted PY - 2009/7/22/entrez PY - 2009/7/22/pubmed PY - 2010/4/30/medline SP - 486 EP - 93 JF - Acta biomaterialia JO - Acta Biomater VL - 6 IS - 2 N2 - Poly(2-hydroxyethyl methacrylate) hydrogels containing beta-cyclodextrin (pHEMA/beta-CD) have been investigated as a platform for sustained release of ophthalmic drugs. First of all, pHEMA/beta-CD hydrogel membranes and contact lenses were prepared by photopolymerization of HEMA, mono-methacrylated beta-CD (mono-MA-beta-CD) and trimethylolpropane trimethacrylate using a cast molding process. The hydrogels were characterized by Fourier transform infrared spectroscopy, equilibrium swelling ratio (ESR) and tensile tester. The results showed that the incorporation of beta-CD in the hydrogels increased the ESR and tensile strength. Then, puerarin was used as a model to evaluate drug loading and in vitro and in vivo release behavior of the pHEMA/beta-CD hydrogels. It was revealed that puerarin loading and in vitro release rate were dependent on beta-CD content in the pHEMA/beta-CD hydrogels. In rabbit eyes the pHEMA/beta-CD hydrogel contact lenses exhibited longer mean residence times (MRT(F)) of puerarin in tear fluid than that of pHEMA contact lenses and 1% puerarin eye drops. The puerarin concentration in the aqueous humor of rabbit reached a maximum of 0.81microg ml(-1) after wearing the pHEMA/beta-CD contact lens, which had been presoaked in 0.802mg ml(-1) puerarin solution for 4.81h. Also, the pHEMA/beta-CD contact lenses had a higher drug bioavailability in aqueous humor than puerarin eye drops. The data demonstrate that pHEMA/beta-CD hydrogel contact lenses can effectively deliver puerarin through the cornea. SN - 1878-7568 UR - https://www.unboundmedicine.com/medline/citation/19619677/Cyclodextrin_containing_hydrogels_for_contact_lenses_as_a_platform_for_drug_incorporation_and_release_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1742-7061(09)00307-9 DB - PRIME DP - Unbound Medicine ER -