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[Discriminatory validity and association of the mini-mental test (MMSE) and the memory alteration test (M@T) with a neuropsychological battery in patients with amnestic mild cognitive impairment and Alzheimer's disease].
Rev Neurol 2009 Aug 16-31; 49(4):169-74RN

Abstract

AIMS

To establish the discriminatory validity of the mini-mental test (MMSE) and the memory alteration test (M@T) for the diagnosis of amnestic mild cognitive impairment (aMCI) and probable Alzheimer's disease (AD), and also to study the association between the results obtained in screening tests, a neuropsychological battery and a functional questionnaire in healthy persons and in patients with aMCI and AD.

SUBJECTS AND METHODS

We evaluated 27 normal controls, 27 patients with aMCI and 35 patients with AD using the MMSE and a memory screening test, the M@T, a neuropsychological battery and a questionnaire on functional activities of daily living. Pearson correlation coefficients were used to evaluate the relations between the scores on the M@T and the MMSE and the neuropsychological tests. The area below the curve, the sensitivity and the specificity were calculated for the screening tests.

RESULTS

In patients with aMCI, the scores on the M@T and the MMSE were strongly associated with the performance in the episodic memory tests in frontal tests and with the scores on the functional questionnaire, but not with tests that evaluated praxias and perceptive functions. In patients with AD, the scores on the M@T and the MMSE were associated with results in semantic memory, language, executive functions and praxias, but not with perceptive tests and functional questionnaires.

CONCLUSIONS

In patients with aMCI and AD, the association between MMSE and M@T only correlate with some cognitive functions, without there being any association with other cognitive functions. Therefore, screening tests cannot be used as the only instrument for evaluating the cognitive status in patients with suspected dementia.

Authors+Show Affiliations

Unidad de Alzheimer y otros trastornos cognitivos, Servicio de Neurología, Instituto de Neurociencias, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain. lrami@clinic.ub.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

19621317

Citation

Rami, L, et al. "[Discriminatory Validity and Association of the Mini-mental Test (MMSE) and the Memory Alteration Test (M@T) With a Neuropsychological Battery in Patients With Amnestic Mild Cognitive Impairment and Alzheimer's Disease]." Revista De Neurologia, vol. 49, no. 4, 2009, pp. 169-74.
Rami L, Bosch B, Valls-Pedret C, et al. [Discriminatory validity and association of the mini-mental test (MMSE) and the memory alteration test (M@T) with a neuropsychological battery in patients with amnestic mild cognitive impairment and Alzheimer's disease]. Rev Neurol. 2009;49(4):169-74.
Rami, L., Bosch, B., Valls-Pedret, C., Caprile, C., Sánchez-Valle Díaz, R., & Molinuevo, J. L. (2009). [Discriminatory validity and association of the mini-mental test (MMSE) and the memory alteration test (M@T) with a neuropsychological battery in patients with amnestic mild cognitive impairment and Alzheimer's disease]. Revista De Neurologia, 49(4), pp. 169-74.
Rami L, et al. [Discriminatory Validity and Association of the Mini-mental Test (MMSE) and the Memory Alteration Test (M@T) With a Neuropsychological Battery in Patients With Amnestic Mild Cognitive Impairment and Alzheimer's Disease]. Rev Neurol. 2009;49(4):169-74. PubMed PMID: 19621317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Discriminatory validity and association of the mini-mental test (MMSE) and the memory alteration test (M@T) with a neuropsychological battery in patients with amnestic mild cognitive impairment and Alzheimer's disease]. AU - Rami,L, AU - Bosch,B, AU - Valls-Pedret,C, AU - Caprile,C, AU - Sánchez-Valle Díaz,R, AU - Molinuevo,J L, PY - 2009/7/22/entrez PY - 2009/7/22/pubmed PY - 2009/10/29/medline SP - 169 EP - 74 JF - Revista de neurologia JO - Rev Neurol VL - 49 IS - 4 N2 - AIMS: To establish the discriminatory validity of the mini-mental test (MMSE) and the memory alteration test (M@T) for the diagnosis of amnestic mild cognitive impairment (aMCI) and probable Alzheimer's disease (AD), and also to study the association between the results obtained in screening tests, a neuropsychological battery and a functional questionnaire in healthy persons and in patients with aMCI and AD. SUBJECTS AND METHODS: We evaluated 27 normal controls, 27 patients with aMCI and 35 patients with AD using the MMSE and a memory screening test, the M@T, a neuropsychological battery and a questionnaire on functional activities of daily living. Pearson correlation coefficients were used to evaluate the relations between the scores on the M@T and the MMSE and the neuropsychological tests. The area below the curve, the sensitivity and the specificity were calculated for the screening tests. RESULTS: In patients with aMCI, the scores on the M@T and the MMSE were strongly associated with the performance in the episodic memory tests in frontal tests and with the scores on the functional questionnaire, but not with tests that evaluated praxias and perceptive functions. In patients with AD, the scores on the M@T and the MMSE were associated with results in semantic memory, language, executive functions and praxias, but not with perceptive tests and functional questionnaires. CONCLUSIONS: In patients with aMCI and AD, the association between MMSE and M@T only correlate with some cognitive functions, without there being any association with other cognitive functions. Therefore, screening tests cannot be used as the only instrument for evaluating the cognitive status in patients with suspected dementia. SN - 1576-6578 UR - https://www.unboundmedicine.com/medline/citation/19621317/[Discriminatory_validity_and_association_of_the_mini_mental_test__MMSE__and_the_memory_alteration_test__M@T__with_a_neuropsychological_battery_in_patients_with_amnestic_mild_cognitive_impairment_and_Alzheimer's_disease]_ L2 - http://www.revneurol.com/LinkOut/formMedLine.asp?Refer=2008623&Revista=RevNeurol DB - PRIME DP - Unbound Medicine ER -