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Microcirculatory modifications of psoriatic lesions during topical therapy.
Skin Res Technol. 2009 May; 15(2):135-8.SR

Abstract

BACKGROUND/PURPOSE

Videocapillaroscopy (VCP) can be used to explore microcirculatory modifications in skin diseases. Psoriasis presents a specifically altered capillaroscopic pattern with 'bushy' capillaries and a disarranged microangioarchitecture. The aim of the present study is to compare the clinical and capillaroscopic modifications of a psoriatic target lesion during topical therapy.

METHODS

Thirty patients with chronic plaque psoriasis were included in the study. Clinical and capillaroscopic modifications in comparable lesions of the elbows were analyzed during different topical therapies (calcipotriol, betamethasone dipropionate and calcipotriol plus betamethasone dipropionate) at baseline, and after 15 and 30 days of therapy. A clinical global score (modified Psoriasis Area Severity Index), the mecapillary density per square mm and the mean diameter of capillary loops were measured.

RESULTS

Topical therapy with combined betamethasone dipropionate and calcipotriol induced a higher decrease in erythema, infiltration and desquamation (P<0.001), and a significant reduction of the mean 'bush' diameter (P<0.001) and capillary number/mm(2) (P<0.05) compared with betamethasone and calcipotriol alone. Microvascular restoration to a normal pattern, as detected by VCP, was faster than clinical improvement (P<0.05).

CONCLUSION

Videocapillaroscopy is an easily executable and non-invasive technique that detects early microcirculatory changes in psoriasis during topical therapy.

Authors+Show Affiliations

Department of Biomedical and Surgical Sciences, Section of Dermatology and Venereology, University of Verona, Verona, Italy. prosina@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

19622121

Citation

Rosina, Paolo, et al. "Microcirculatory Modifications of Psoriatic Lesions During Topical Therapy." Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), vol. 15, no. 2, 2009, pp. 135-8.
Rosina P, Giovannini A, Gisondi P, et al. Microcirculatory modifications of psoriatic lesions during topical therapy. Skin Res Technol. 2009;15(2):135-8.
Rosina, P., Giovannini, A., Gisondi, P., & Girolomoni, G. (2009). Microcirculatory modifications of psoriatic lesions during topical therapy. Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 15(2), 135-8. https://doi.org/10.1111/j.1600-0846.2008.00336.x
Rosina P, et al. Microcirculatory Modifications of Psoriatic Lesions During Topical Therapy. Skin Res Technol. 2009;15(2):135-8. PubMed PMID: 19622121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microcirculatory modifications of psoriatic lesions during topical therapy. AU - Rosina,Paolo, AU - Giovannini,Andrea, AU - Gisondi,Paolo, AU - Girolomoni,Giampiero, Y1 - 2009/01/13/ PY - 2009/7/23/entrez PY - 2009/7/23/pubmed PY - 2009/10/9/medline SP - 135 EP - 8 JF - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) JO - Skin Res Technol VL - 15 IS - 2 N2 - BACKGROUND/PURPOSE: Videocapillaroscopy (VCP) can be used to explore microcirculatory modifications in skin diseases. Psoriasis presents a specifically altered capillaroscopic pattern with 'bushy' capillaries and a disarranged microangioarchitecture. The aim of the present study is to compare the clinical and capillaroscopic modifications of a psoriatic target lesion during topical therapy. METHODS: Thirty patients with chronic plaque psoriasis were included in the study. Clinical and capillaroscopic modifications in comparable lesions of the elbows were analyzed during different topical therapies (calcipotriol, betamethasone dipropionate and calcipotriol plus betamethasone dipropionate) at baseline, and after 15 and 30 days of therapy. A clinical global score (modified Psoriasis Area Severity Index), the mecapillary density per square mm and the mean diameter of capillary loops were measured. RESULTS: Topical therapy with combined betamethasone dipropionate and calcipotriol induced a higher decrease in erythema, infiltration and desquamation (P<0.001), and a significant reduction of the mean 'bush' diameter (P<0.001) and capillary number/mm(2) (P<0.05) compared with betamethasone and calcipotriol alone. Microvascular restoration to a normal pattern, as detected by VCP, was faster than clinical improvement (P<0.05). CONCLUSION: Videocapillaroscopy is an easily executable and non-invasive technique that detects early microcirculatory changes in psoriasis during topical therapy. SN - 1600-0846 UR - https://www.unboundmedicine.com/medline/citation/19622121/Microcirculatory_modifications_of_psoriatic_lesions_during_topical_therapy_ L2 - https://doi.org/10.1111/j.1600-0846.2008.00336.x DB - PRIME DP - Unbound Medicine ER -