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Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome.
Gastroenterology 2009; 137(5):1621-7G

Abstract

BACKGROUND & AIMS

Lynch syndrome is the most common hereditary colorectal cancer (CRC) syndrome. Some previous estimates of lifetime risk for CRC and endometrial cancer (EC) did not control for ascertainment and were susceptible to bias toward overestimated risk.

METHODS

We studied 147 families with mismatch repair gene mutations (55 MLH1, 81 MSH2, and 11 MSH6) identified at 2 US cancer genetics clinics. Age-specific cumulative risks (penetrance) and hazard ratio (HR) estimates of CRC and EC risks were calculated and compared with the general population using modified segregation analysis. The likelihood for each pedigree was conditioned on the proband and first-degree relatives affected with CRC to reduce ascertainment bias and overestimation of penetrance.

RESULTS

We analyzed 628 cases of CRC, diagnosed at the median ages of 42 and 47 years for men and women, respectively. The cumulative risk of CRC was 66.08% (95% confidence interval [CI], 59.47%-76.17%) for men and 42.71% (95% CI, 36.57%-52.83%) for women, with overall HRs of 148.4 and 51.1, respectively. CRC risk was highest for males with mutations in MLH1. There were 155 cases of EC, diagnosed at a median age of 47.5 years. The cumulative risk of EC was 39.39% (95% CI, 30.78%-46.94%) with an overall HR of 39.0 (95% CI, 30.4-50.2). For women, the cumulative risk of CRC or EC was 73.42% (95% CI, 63.76%-80.54%).

CONCLUSIONS

Lifetime risks of CRC and EC in mismatch repair gene mutation carriers are high even after adjusting for ascertainment. These estimates are valuable for patients and providers; specialized cancer surveillance is necessary.

Authors+Show Affiliations

Brigham and Women's Hospital, Boston, Massachusetts; Dana-Farber Cancer Institute, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19622357

Citation

Stoffel, Elena, et al. "Calculation of Risk of Colorectal and Endometrial Cancer Among Patients With Lynch Syndrome." Gastroenterology, vol. 137, no. 5, 2009, pp. 1621-7.
Stoffel E, Mukherjee B, Raymond VM, et al. Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome. Gastroenterology. 2009;137(5):1621-7.
Stoffel, E., Mukherjee, B., Raymond, V. M., Tayob, N., Kastrinos, F., Sparr, J., ... Gruber, S. B. (2009). Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome. Gastroenterology, 137(5), pp. 1621-7. doi:10.1053/j.gastro.2009.07.039.
Stoffel E, et al. Calculation of Risk of Colorectal and Endometrial Cancer Among Patients With Lynch Syndrome. Gastroenterology. 2009;137(5):1621-7. PubMed PMID: 19622357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome. AU - Stoffel,Elena, AU - Mukherjee,Bhramar, AU - Raymond,Victoria M, AU - Tayob,Nabihah, AU - Kastrinos,Fay, AU - Sparr,Jennifer, AU - Wang,Fei, AU - Bandipalliam,Prathap, AU - Syngal,Sapna, AU - Gruber,Stephen B, Y1 - 2009/07/18/ PY - 2009/05/08/received PY - 2009/06/26/revised PY - 2009/07/08/accepted PY - 2009/7/23/entrez PY - 2009/7/23/pubmed PY - 2009/12/16/medline SP - 1621 EP - 7 JF - Gastroenterology JO - Gastroenterology VL - 137 IS - 5 N2 - BACKGROUND & AIMS: Lynch syndrome is the most common hereditary colorectal cancer (CRC) syndrome. Some previous estimates of lifetime risk for CRC and endometrial cancer (EC) did not control for ascertainment and were susceptible to bias toward overestimated risk. METHODS: We studied 147 families with mismatch repair gene mutations (55 MLH1, 81 MSH2, and 11 MSH6) identified at 2 US cancer genetics clinics. Age-specific cumulative risks (penetrance) and hazard ratio (HR) estimates of CRC and EC risks were calculated and compared with the general population using modified segregation analysis. The likelihood for each pedigree was conditioned on the proband and first-degree relatives affected with CRC to reduce ascertainment bias and overestimation of penetrance. RESULTS: We analyzed 628 cases of CRC, diagnosed at the median ages of 42 and 47 years for men and women, respectively. The cumulative risk of CRC was 66.08% (95% confidence interval [CI], 59.47%-76.17%) for men and 42.71% (95% CI, 36.57%-52.83%) for women, with overall HRs of 148.4 and 51.1, respectively. CRC risk was highest for males with mutations in MLH1. There were 155 cases of EC, diagnosed at a median age of 47.5 years. The cumulative risk of EC was 39.39% (95% CI, 30.78%-46.94%) with an overall HR of 39.0 (95% CI, 30.4-50.2). For women, the cumulative risk of CRC or EC was 73.42% (95% CI, 63.76%-80.54%). CONCLUSIONS: Lifetime risks of CRC and EC in mismatch repair gene mutation carriers are high even after adjusting for ascertainment. These estimates are valuable for patients and providers; specialized cancer surveillance is necessary. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/19622357/Calculation_of_risk_of_colorectal_and_endometrial_cancer_among_patients_with_Lynch_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(09)01158-5 DB - PRIME DP - Unbound Medicine ER -