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Influence of tonic and burst transcranial magnetic stimulation characteristics on acute inhibition of subjective tinnitus.
Otol Neurotol. 2009 Sep; 30(6):697-703.ON

Abstract

OBJECTIVE

Transcranial magnetic stimulation (TMS) is already broadly used in different areas of neuroscience research. In the last years, special attention was drawn to TMS in tinnitus. The aim of our study is to investigate the stimulation characteristics of TMS in tinnitus patients, in particular the effect of tonic and burst stimulation of the superior temporal lobe.

STUDY DESIGN

Prospective sham-controlled study.

SETTING

Tertiary referral center.

PATIENTS

Fifty tinnitus patients were included in the study. Thirty-one patients had pure-tone tinnitus, and 19 patients had noise-like tinnitus.

STUDY DESIGN

Transcranial magnetic stimulation was performed in 1 session of 200 pulses at different frequencies. Stimuli were delivered to the auditory cortex region contralateral to the tinnitus side. Tonic and burst stimulations were delivered at different frequencies. Patients were asked to rate the acute tinnitus reduction after TMS on a visual analog scale.

MAIN OUTCOME MEASURE

Acutely perceived tinnitus reduction immediately after TMS, scored by the patient on a visual analogue scale ranging from 0 to 100%.

RESULTS

Tinnitus reduction increased when stimulation intensity was higher relative to the patient's motor threshold. Nevertheless, this stimulation intensity was shown only to account for 10% of this increased tinnitus reduction, meaning that up to 90% of this effect should be ascribed to other factors than stimulation intensity alone. Different reactions on TMS were found in bilateral tinnitus patients compared with unilateral tinnitus patients.

CONCLUSION

Several parameters determine the amount of tinnitus reduction after TMS. An increased stimulation intensity relative to the patient's motor threshold only accounts for 10% of this effect. Our data also suggest different pathophysiologic mechanisms for unilateral and bilateral tinnitus.

Authors+Show Affiliations

University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium. olivier.meeus@uza.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19623097

Citation

Meeus, Olivier, et al. "Influence of Tonic and Burst Transcranial Magnetic Stimulation Characteristics On Acute Inhibition of Subjective Tinnitus." Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, vol. 30, no. 6, 2009, pp. 697-703.
Meeus O, Blaivie C, Ost J, et al. Influence of tonic and burst transcranial magnetic stimulation characteristics on acute inhibition of subjective tinnitus. Otol Neurotol. 2009;30(6):697-703.
Meeus, O., Blaivie, C., Ost, J., De Ridder, D., & Van de Heyning, P. (2009). Influence of tonic and burst transcranial magnetic stimulation characteristics on acute inhibition of subjective tinnitus. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 30(6), 697-703. https://doi.org/10.1097/MAO.0b013e3181b05023
Meeus O, et al. Influence of Tonic and Burst Transcranial Magnetic Stimulation Characteristics On Acute Inhibition of Subjective Tinnitus. Otol Neurotol. 2009;30(6):697-703. PubMed PMID: 19623097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of tonic and burst transcranial magnetic stimulation characteristics on acute inhibition of subjective tinnitus. AU - Meeus,Olivier, AU - Blaivie,Catherine, AU - Ost,Jan, AU - De Ridder,Dirk, AU - Van de Heyning,Paul, PY - 2009/7/23/entrez PY - 2009/7/23/pubmed PY - 2009/11/17/medline SP - 697 EP - 703 JF - Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology JO - Otol Neurotol VL - 30 IS - 6 N2 - OBJECTIVE: Transcranial magnetic stimulation (TMS) is already broadly used in different areas of neuroscience research. In the last years, special attention was drawn to TMS in tinnitus. The aim of our study is to investigate the stimulation characteristics of TMS in tinnitus patients, in particular the effect of tonic and burst stimulation of the superior temporal lobe. STUDY DESIGN: Prospective sham-controlled study. SETTING: Tertiary referral center. PATIENTS: Fifty tinnitus patients were included in the study. Thirty-one patients had pure-tone tinnitus, and 19 patients had noise-like tinnitus. STUDY DESIGN: Transcranial magnetic stimulation was performed in 1 session of 200 pulses at different frequencies. Stimuli were delivered to the auditory cortex region contralateral to the tinnitus side. Tonic and burst stimulations were delivered at different frequencies. Patients were asked to rate the acute tinnitus reduction after TMS on a visual analog scale. MAIN OUTCOME MEASURE: Acutely perceived tinnitus reduction immediately after TMS, scored by the patient on a visual analogue scale ranging from 0 to 100%. RESULTS: Tinnitus reduction increased when stimulation intensity was higher relative to the patient's motor threshold. Nevertheless, this stimulation intensity was shown only to account for 10% of this increased tinnitus reduction, meaning that up to 90% of this effect should be ascribed to other factors than stimulation intensity alone. Different reactions on TMS were found in bilateral tinnitus patients compared with unilateral tinnitus patients. CONCLUSION: Several parameters determine the amount of tinnitus reduction after TMS. An increased stimulation intensity relative to the patient's motor threshold only accounts for 10% of this effect. Our data also suggest different pathophysiologic mechanisms for unilateral and bilateral tinnitus. SN - 1537-4505 UR - https://www.unboundmedicine.com/medline/citation/19623097/Influence_of_tonic_and_burst_transcranial_magnetic_stimulation_characteristics_on_acute_inhibition_of_subjective_tinnitus_ L2 - https://doi.org/10.1097/MAO.0b013e3181b05023 DB - PRIME DP - Unbound Medicine ER -