Tags

Type your tag names separated by a space and hit enter

Phytochemical investigation and cytotoxic evaluation of the components of the medicinal plant Ligularia atroviolacea.
Chem Biodivers. 2009 Jul; 6(7):1053-65.CB

Abstract

A phytochemical investigation of the roots of Ligularia atroviolacea resulted in the isolation of 24 compounds including seven new eremophilanoids named eremophila-3,7(11),8-triene-12,8;14,6alpha-diolide (1), 3beta-(angeloyloxy)eremophil-7(11)-en-12,8beta-olid-14-oic acid (2), 1alpha-chloro-10beta-hydroxy-6beta-(2-methylpropanoyloxy)-9-oxo-7,8-furoeremophilane (3), (10betaH)-8-oxoeremophila-3(4),6(7)-diene-12,14-dioic acid (4), (10alphaH)-8-oxoeremophila-3(4),6(7)-diene-12,14-dioic acid (5), 8beta-[eremophila-3',7'(11')-diene-12',8'alpha;14',6'alpha-diolide]eremophila-3,7(11)-diene-12,8alpha;14,6alpha-diolide (6), and ligulatrovine A (7), eleven known eremophilanoids, 8-18, four steroids, one glucose derivative, and one fatty acid. The structures of these compounds were elucidated by spectroscopic methods including 2D-NMR experiments. The structure of 3 was also established by an X-ray diffraction study. The in vitro cytotoxicity evaluation of selected compounds was performed on seven cultured tumor cell lines, i.e., KB, BEL-7404, A549, HL-60, HeLa, CNE, and P-388D1. The preliminary taxonomy of this species was also discussed, and the possible biogenesis of a dimer possessing a new noreremophilanoid type skeleton, 7, is presented in a preliminary form.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Wang X
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China.
Sun L
No affiliation info available
Huang K
No affiliation info available
Shi S
No affiliation info available
Zhang L
No affiliation info available
Xu J
No affiliation info available
Peng H
No affiliation info available
Sun X
No affiliation info available
Wang L
No affiliation info available
Wu X
No affiliation info available
Zhao Y
No affiliation info available
Li X
No affiliation info available
Stöckigt J
No affiliation info available
Qu J
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicAsteraceaeCell Line, TumorCrystallography, X-RayDrug Screening Assays, AntitumorHumansMagnetic Resonance SpectroscopyMolecular ConformationOrganic ChemicalsPlant ExtractsPlant RootsPlants, Medicinal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19623551

Citation

Wang, Xiaoyu, et al. "Phytochemical Investigation and Cytotoxic Evaluation of the Components of the Medicinal Plant Ligularia Atroviolacea." Chemistry & Biodiversity, vol. 6, no. 7, 2009, pp. 1053-65.
Wang X, Sun L, Huang K, et al. Phytochemical investigation and cytotoxic evaluation of the components of the medicinal plant Ligularia atroviolacea. Chem Biodivers. 2009;6(7):1053-65.
Wang, X., Sun, L., Huang, K., Shi, S., Zhang, L., Xu, J., Peng, H., Sun, X., Wang, L., Wu, X., Zhao, Y., Li, X., Stöckigt, J., & Qu, J. (2009). Phytochemical investigation and cytotoxic evaluation of the components of the medicinal plant Ligularia atroviolacea. Chemistry & Biodiversity, 6(7), 1053-65. https://doi.org/10.1002/cbdv.200800128
Wang X, et al. Phytochemical Investigation and Cytotoxic Evaluation of the Components of the Medicinal Plant Ligularia Atroviolacea. Chem Biodivers. 2009;6(7):1053-65. PubMed PMID: 19623551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemical investigation and cytotoxic evaluation of the components of the medicinal plant Ligularia atroviolacea. AU - Wang,Xiaoyu, AU - Sun,Lianli, AU - Huang,Kexin, AU - Shi,Shuyun, AU - Zhang,Lijuan, AU - Xu,Juanhua, AU - Peng,Hua, AU - Sun,Xianfeng, AU - Wang,Liwei, AU - Wu,Xiumei, AU - Zhao,Yu, AU - Li,Xiaokun, AU - Stöckigt,Joachim, AU - Qu,Jia, PY - 2009/7/23/entrez PY - 2009/7/23/pubmed PY - 2009/10/27/medline SP - 1053 EP - 65 JF - Chemistry & biodiversity JO - Chem Biodivers VL - 6 IS - 7 N2 - A phytochemical investigation of the roots of Ligularia atroviolacea resulted in the isolation of 24 compounds including seven new eremophilanoids named eremophila-3,7(11),8-triene-12,8;14,6alpha-diolide (1), 3beta-(angeloyloxy)eremophil-7(11)-en-12,8beta-olid-14-oic acid (2), 1alpha-chloro-10beta-hydroxy-6beta-(2-methylpropanoyloxy)-9-oxo-7,8-furoeremophilane (3), (10betaH)-8-oxoeremophila-3(4),6(7)-diene-12,14-dioic acid (4), (10alphaH)-8-oxoeremophila-3(4),6(7)-diene-12,14-dioic acid (5), 8beta-[eremophila-3',7'(11')-diene-12',8'alpha;14',6'alpha-diolide]eremophila-3,7(11)-diene-12,8alpha;14,6alpha-diolide (6), and ligulatrovine A (7), eleven known eremophilanoids, 8-18, four steroids, one glucose derivative, and one fatty acid. The structures of these compounds were elucidated by spectroscopic methods including 2D-NMR experiments. The structure of 3 was also established by an X-ray diffraction study. The in vitro cytotoxicity evaluation of selected compounds was performed on seven cultured tumor cell lines, i.e., KB, BEL-7404, A549, HL-60, HeLa, CNE, and P-388D1. The preliminary taxonomy of this species was also discussed, and the possible biogenesis of a dimer possessing a new noreremophilanoid type skeleton, 7, is presented in a preliminary form. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/19623551/Phytochemical_investigation_and_cytotoxic_evaluation_of_the_components_of_the_medicinal_plant_Ligularia_atroviolacea_ L2 - https://doi.org/10.1002/cbdv.200800128 DB - PRIME DP - Unbound Medicine ER -