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[Endometriosis. Pathophysiological background for treatment].

Abstract

Endometriosis is the third cause of gynecological morbidity and the complications are associated to ectopically endometrial tissue implantation. The interest on this disease is the functional disability and its association with sterility. It has been established that endometrial growth is estrogen-dependent and that progesterone inhibits the cellular proliferation mediated by estrogens, therefore in endometriosis there is not an adequate response to hormonal signals that control the proliferative activity. It has been described that peritoneal fluid in women with endometriosis has high concentrations of cytokines, growth factors and activated macrophages, which have been shown to have adverse effects on fertility. Therefore, these are not the only causes of infertility since it has been described that women with endometriosis seem to have poor ovarian reserve and ovular quality. When there is infertility, the tendency is to treat the endometriosis due to the changes caused by ectopic tissue presented at the immunological level and in the structure of genital organs, which disturbs the conception process. It has been observed that endometriosis recurs after a surgical procedure. For this reason we should be consider all therapeutic possibilities.

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Authors+Show Affiliations

,

Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México, Mexico. mhernandezvalencia@prodigy.net.mx

Source

MeSH

Endometriosis
Female
Humans

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

19624966

Citation

Hernández-Valencia, Marcelino, and Arturo Zárate. "[Endometriosis. Pathophysiological Background for Treatment]." Revista Medica Del Instituto Mexicano Del Seguro Social, vol. 47, no. 1, 2009, pp. 57-60.
Hernández-Valencia M, Zárate A. [Endometriosis. Pathophysiological background for treatment]. Rev Med Inst Mex Seguro Soc. 2009;47(1):57-60.
Hernández-Valencia, M., & Zárate, A. (2009). [Endometriosis. Pathophysiological background for treatment]. Revista Medica Del Instituto Mexicano Del Seguro Social, 47(1), pp. 57-60.
Hernández-Valencia M, Zárate A. [Endometriosis. Pathophysiological Background for Treatment]. Rev Med Inst Mex Seguro Soc. 2009;47(1):57-60. PubMed PMID: 19624966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Endometriosis. Pathophysiological background for treatment]. AU - Hernández-Valencia,Marcelino, AU - Zárate,Arturo, PY - 2009/7/24/entrez PY - 2009/7/25/pubmed PY - 2010/8/27/medline SP - 57 EP - 60 JF - Revista medica del Instituto Mexicano del Seguro Social JO - Rev Med Inst Mex Seguro Soc VL - 47 IS - 1 N2 - Endometriosis is the third cause of gynecological morbidity and the complications are associated to ectopically endometrial tissue implantation. The interest on this disease is the functional disability and its association with sterility. It has been established that endometrial growth is estrogen-dependent and that progesterone inhibits the cellular proliferation mediated by estrogens, therefore in endometriosis there is not an adequate response to hormonal signals that control the proliferative activity. It has been described that peritoneal fluid in women with endometriosis has high concentrations of cytokines, growth factors and activated macrophages, which have been shown to have adverse effects on fertility. Therefore, these are not the only causes of infertility since it has been described that women with endometriosis seem to have poor ovarian reserve and ovular quality. When there is infertility, the tendency is to treat the endometriosis due to the changes caused by ectopic tissue presented at the immunological level and in the structure of genital organs, which disturbs the conception process. It has been observed that endometriosis recurs after a surgical procedure. For this reason we should be consider all therapeutic possibilities. SN - 0443-5117 UR - https://www.unboundmedicine.com/medline/citation/19624966/[Endometriosis__Pathophysiological_background_for_treatment]_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -