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Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry.
Respir Med. 2010 Jan; 104(1):34-9.RM

Abstract

BACKGROUND

ADAM8 (a disintegrin and a metalloprotease 8) has been linked to asthma and eosinophilic pneumonia (EP). ADAM8 cleaves a variety of substrates and is a sheddase for CD23, the low affinity IgE receptor. The concentration of soluble ADAM8 (sADAM8) is increased in bronchoalveolar lavage fluid (BALF) from patients with smoking-induced acute eosinophilic pneumonia (AEP) and chronic eosinophilic pneumonia (CEP), but not drug-induced EP (Drug-EP). In AEP, the BALF sADAM8 concentration significantly correlates with the soluble CD23 concentration (sCD23).

METHODS

To evaluate the involvement of ADAM8 in the pathogenesis of eosinophilic pneumonia, we measured the concentrations of sADAM8 and its substrate, soluble CD23 (sCD23), in serum from patients with AEP, CEP, and Drug-EP. We also measured the change in the sADAM8 concentration after a provocation test.

RESULTS

In contrast to the BALF findings, serum sADAM8 concentrations were increased in Drug-EP (mean+/-SEM; 639.6+/-49.15) and serum ADAM8 levels correlated positively with the serum sCD23 levels in patients with Drug-EP (P=0.0080, R(2)=0.8465). Serum sADAM8 concentrations were also increased in AEP (409+/-76.91) and CEP (644.7+/-87.03). Serum ADAM8 concentrations were also elevated after the provocation test.

CONCLUSION

Serum ADAM8 concentrations were elevated in Drug-EP, although the sADAM8 concentrations were not increased in the BALF in Drug-EP. Thus, the pathogenesis of AEP and Drug-EP may be distinct with regard to allergen exposure; AEP may be caused by the inhalation of antigens, whereas Drug-EP may be caused by bloodstream antigens. These findings indicate that ADAM8 levels reflect the route of eosinophilic inflammation in EP.

Authors+Show Affiliations

Division of Respiratory Disease, Osaka Minami Medical Center, Kidohigashimachi 2-1, Kawachinagano city, Osaka 586-8521, Japan. matsuno@med.oita-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19625177

Citation

Matsuno, Osamu, et al. "Increased Serum ADAM8 Concentration in Patients With Drug-induced Eosinophilic pneumonia-ADAM8 Expression Depends On a the Allergen Route of Entry." Respiratory Medicine, vol. 104, no. 1, 2010, pp. 34-9.
Matsuno O, Ono E, Ueno T, et al. Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry. Respir Med. 2010;104(1):34-9.
Matsuno, O., Ono, E., Ueno, T., Takenaka, R., Nishitake, T., Hiroshige, S., Miyazaki, E., Kumamoto, T., & Higuchi, Y. (2010). Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry. Respiratory Medicine, 104(1), 34-9. https://doi.org/10.1016/j.rmed.2009.06.018
Matsuno O, et al. Increased Serum ADAM8 Concentration in Patients With Drug-induced Eosinophilic pneumonia-ADAM8 Expression Depends On a the Allergen Route of Entry. Respir Med. 2010;104(1):34-9. PubMed PMID: 19625177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry. AU - Matsuno,Osamu, AU - Ono,Emiko, AU - Ueno,Takuya, AU - Takenaka,Ryuichi, AU - Nishitake,Takahiro, AU - Hiroshige,Shigeo, AU - Miyazaki,Eishi, AU - Kumamoto,Toshihide, AU - Higuchi,Yasunori, Y1 - 2009/07/21/ PY - 2009/05/12/received PY - 2009/06/25/revised PY - 2009/06/26/accepted PY - 2009/7/24/entrez PY - 2009/7/25/pubmed PY - 2010/9/10/medline SP - 34 EP - 9 JF - Respiratory medicine JO - Respir Med VL - 104 IS - 1 N2 - BACKGROUND: ADAM8 (a disintegrin and a metalloprotease 8) has been linked to asthma and eosinophilic pneumonia (EP). ADAM8 cleaves a variety of substrates and is a sheddase for CD23, the low affinity IgE receptor. The concentration of soluble ADAM8 (sADAM8) is increased in bronchoalveolar lavage fluid (BALF) from patients with smoking-induced acute eosinophilic pneumonia (AEP) and chronic eosinophilic pneumonia (CEP), but not drug-induced EP (Drug-EP). In AEP, the BALF sADAM8 concentration significantly correlates with the soluble CD23 concentration (sCD23). METHODS: To evaluate the involvement of ADAM8 in the pathogenesis of eosinophilic pneumonia, we measured the concentrations of sADAM8 and its substrate, soluble CD23 (sCD23), in serum from patients with AEP, CEP, and Drug-EP. We also measured the change in the sADAM8 concentration after a provocation test. RESULTS: In contrast to the BALF findings, serum sADAM8 concentrations were increased in Drug-EP (mean+/-SEM; 639.6+/-49.15) and serum ADAM8 levels correlated positively with the serum sCD23 levels in patients with Drug-EP (P=0.0080, R(2)=0.8465). Serum sADAM8 concentrations were also increased in AEP (409+/-76.91) and CEP (644.7+/-87.03). Serum ADAM8 concentrations were also elevated after the provocation test. CONCLUSION: Serum ADAM8 concentrations were elevated in Drug-EP, although the sADAM8 concentrations were not increased in the BALF in Drug-EP. Thus, the pathogenesis of AEP and Drug-EP may be distinct with regard to allergen exposure; AEP may be caused by the inhalation of antigens, whereas Drug-EP may be caused by bloodstream antigens. These findings indicate that ADAM8 levels reflect the route of eosinophilic inflammation in EP. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/19625177/Increased_serum_ADAM8_concentration_in_patients_with_drug_induced_eosinophilic_pneumonia_ADAM8_expression_depends_on_a_the_allergen_route_of_entry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(09)00222-4 DB - PRIME DP - Unbound Medicine ER -