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Effect of family history on the incidence of varicose veins: a population-based follow-up study in Finland.

Abstract

In the literature, the estimates of high risk of family history for varicose veins are based on prevalence rates from cross-sectional studies. The purpose of this study was to compare such prevalence rates with incidence rates from our longitudinal follow-up study to find out whether there is a difference due to the methodology. A validated questionnaire was used in 3 middle-aged cohorts (n = 6874) in Tampere, Finland. Positive family history was more common both in men (prevalence odds ratio 6.6; 95% confidence interval, 4.7-9.3) and women (4.9; 95% confidence interval, 4.0-6.0) with varicose veins compared to those without. However, positive family history was linked much less with the incidence of varicose veins than the prevalence of varicose veins in women (incidence odds ratio 1.8; 95% confidence interval, 1.1-2.8) and men 1.4 (95% confidence interval, 0.7-2.6). There is likely to be a hereditary component of varicose veins, but it is substantially less than usually proposed in literature.

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  • Authors+Show Affiliations

    ,

    Tampere School of Public Health, 33014 University of Tampere, Finland. tiina.jukkola@uta.fi

    , , ,

    Source

    Angiology 60:4 pg 487-91

    MeSH

    Adult
    Aged
    Female
    Finland
    Follow-Up Studies
    Genetic Predisposition to Disease
    Humans
    Incidence
    Logistic Models
    Longitudinal Studies
    Male
    Middle Aged
    Odds Ratio
    Pedigree
    Population Surveillance
    Risk Assessment
    Risk Factors
    Sex Factors
    Surveys and Questionnaires
    Varicose Veins

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19625267

    Citation

    Ahti, Tiina M., et al. "Effect of Family History On the Incidence of Varicose Veins: a Population-based Follow-up Study in Finland." Angiology, vol. 60, no. 4, 2009, pp. 487-91.
    Ahti TM, Mäkivaara LA, Luukkaala T, et al. Effect of family history on the incidence of varicose veins: a population-based follow-up study in Finland. Angiology. 2009;60(4):487-91.
    Ahti, T. M., Mäkivaara, L. A., Luukkaala, T., Hakama, M., & Laurikka, J. O. (2009). Effect of family history on the incidence of varicose veins: a population-based follow-up study in Finland. Angiology, 60(4), pp. 487-91. doi:10.1177/0003319709335510.
    Ahti TM, et al. Effect of Family History On the Incidence of Varicose Veins: a Population-based Follow-up Study in Finland. Angiology. 2009;60(4):487-91. PubMed PMID: 19625267.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of family history on the incidence of varicose veins: a population-based follow-up study in Finland. AU - Ahti,Tiina M, AU - Mäkivaara,Liisa A, AU - Luukkaala,Tiina, AU - Hakama,Matti, AU - Laurikka,Jari O, Y1 - 2009/07/21/ PY - 2009/7/24/entrez PY - 2009/7/25/pubmed PY - 2009/10/2/medline SP - 487 EP - 91 JF - Angiology JO - Angiology VL - 60 IS - 4 N2 - In the literature, the estimates of high risk of family history for varicose veins are based on prevalence rates from cross-sectional studies. The purpose of this study was to compare such prevalence rates with incidence rates from our longitudinal follow-up study to find out whether there is a difference due to the methodology. A validated questionnaire was used in 3 middle-aged cohorts (n = 6874) in Tampere, Finland. Positive family history was more common both in men (prevalence odds ratio 6.6; 95% confidence interval, 4.7-9.3) and women (4.9; 95% confidence interval, 4.0-6.0) with varicose veins compared to those without. However, positive family history was linked much less with the incidence of varicose veins than the prevalence of varicose veins in women (incidence odds ratio 1.8; 95% confidence interval, 1.1-2.8) and men 1.4 (95% confidence interval, 0.7-2.6). There is likely to be a hereditary component of varicose veins, but it is substantially less than usually proposed in literature. SN - 1940-1574 UR - https://www.unboundmedicine.com/medline/citation/19625267/Effect_of_family_history_on_the_incidence_of_varicose_veins:_a_population_based_follow_up_study_in_Finland_ L2 - http://journals.sagepub.com/doi/full/10.1177/0003319709335510?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -