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Effects of Guilingji on brain monoamines and their metabolites in mice.
Acta Med Okayama. 1991 Aug; 45(4):217-22.AM

Abstract

Guillingji powder, a complex prescription of traditional Chinese medicines, has been pharmacologically shown to be a possible anti-aging agent, and also used for the treatment of male hypogonadism and female dysgenesis. Since the levels of numerous brain monoamines and their metabolites such as norepinephrine (NE), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) have been correlated with aging, we examined the effects of Guilingji powder and its extract on such monoamines and metabolites in the cerebrum and the cerebellum of mice using HPLC-ECD. The results showed that dietary intake of Guilingji powder had the effect of increasing the NE level and the DOPAC/DA ratio, and decreasing the 5-HT level and 5-HT/NE ratio in the cerebrum. In the cerebellum, the powder did not produce any changes in the levels of the compounds investigated. The extract of Guilingji, on the other hand, not only increased the NE level and the DOPAC/DA ratio but also the 5-HIAA/5-HT ratio in the cerebrum. However, the extract did not decrease the 5-HT in the cerebrum, although it decreased the 5-HT/NE. Unlike the powder, the extract had an effect in the cerebellum, which increased the DOPAC/DA ratio. These results suggest that Guilingji may have the action of modulating the levels and the metabolism of monoamines.

Authors+Show Affiliations

Liu JK
Department of Neurochemistry, Okayama University Medical School, Japan.
Kabuto H
No affiliation info available
Hiramatsu M
No affiliation info available
Mori A
No affiliation info available

MeSH

AnimalsBiogenic MonoaminesBrain ChemistryChromatography, High Pressure LiquidDrugs, Chinese HerbalMaleMiceMice, Inbred Strains

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1962529

Citation

Liu, J K., et al. "Effects of Guilingji On Brain Monoamines and Their Metabolites in Mice." Acta Medica Okayama, vol. 45, no. 4, 1991, pp. 217-22.
Liu JK, Kabuto H, Hiramatsu M, et al. Effects of Guilingji on brain monoamines and their metabolites in mice. Acta Med Okayama. 1991;45(4):217-22.
Liu, J. K., Kabuto, H., Hiramatsu, M., & Mori, A. (1991). Effects of Guilingji on brain monoamines and their metabolites in mice. Acta Medica Okayama, 45(4), 217-22.
Liu JK, et al. Effects of Guilingji On Brain Monoamines and Their Metabolites in Mice. Acta Med Okayama. 1991;45(4):217-22. PubMed PMID: 1962529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Guilingji on brain monoamines and their metabolites in mice. AU - Liu,J K, AU - Kabuto,H, AU - Hiramatsu,M, AU - Mori,A, PY - 1991/8/1/pubmed PY - 1991/8/1/medline PY - 1991/8/1/entrez SP - 217 EP - 22 JF - Acta medica Okayama JO - Acta Med Okayama VL - 45 IS - 4 N2 - Guillingji powder, a complex prescription of traditional Chinese medicines, has been pharmacologically shown to be a possible anti-aging agent, and also used for the treatment of male hypogonadism and female dysgenesis. Since the levels of numerous brain monoamines and their metabolites such as norepinephrine (NE), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) have been correlated with aging, we examined the effects of Guilingji powder and its extract on such monoamines and metabolites in the cerebrum and the cerebellum of mice using HPLC-ECD. The results showed that dietary intake of Guilingji powder had the effect of increasing the NE level and the DOPAC/DA ratio, and decreasing the 5-HT level and 5-HT/NE ratio in the cerebrum. In the cerebellum, the powder did not produce any changes in the levels of the compounds investigated. The extract of Guilingji, on the other hand, not only increased the NE level and the DOPAC/DA ratio but also the 5-HIAA/5-HT ratio in the cerebrum. However, the extract did not decrease the 5-HT in the cerebrum, although it decreased the 5-HT/NE. Unlike the powder, the extract had an effect in the cerebellum, which increased the DOPAC/DA ratio. These results suggest that Guilingji may have the action of modulating the levels and the metabolism of monoamines. SN - 0386-300X UR - https://www.unboundmedicine.com/medline/citation/1962529/Effects_of_Guilingji_on_brain_monoamines_and_their_metabolites_in_mice_ DB - PRIME DP - Unbound Medicine ER -