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Dietary fiber intake and risk of breast cancer in postmenopausal women: the National Institutes of Health-AARP Diet and Health Study.

Abstract

BACKGROUND

Although dietary fiber has been hypothesized to lower risk of breast cancer by modulating estrogen metabolism, the association between dietary fiber intake and risk of breast cancer by hormone receptor status is unclear.

OBJECTIVE

The objective was to examine the relation of dietary fiber intake to breast cancer by hormone receptor status and histologic type among postmenopausal women in the National Institutes of Health-AARP Diet and Health Study (n = 185,598; mean age: 62 y).

DESIGN

Dietary intakes were assessed with a food-frequency questionnaire. Incident breast cancer cases were identified through linkage with state cancer registries. Cox proportional hazard models were used to estimate relative risks (RRs) and 2-sided 95% CIs.

RESULTS

During an average of 7 y of follow-up, 5461 breast cancer cases were identified, of which 3341 cases had estrogen receptor (ER) and progesterone receptor (PR) status. Dietary fiber intake was inversely associated with breast cancer risk [RR for the highest quintile (Q5) compared with the lowest quintile (Q1): 0.87; 95% CI: 0.77, 0.98; P for trend: 0.02]. The inverse association appeared to be stronger for ER(-)/PR(-) tumors (RR(Q5vsQ1): 0.56; 95% CI: 0.35, 0.90; P for trend: 0.008; 366 cases) than for ER(+)/PR(+) tumors (RR(Q5vsQ1): 0.95; 95% CI: 0.76, 1.20; P for trend: 0.47; 1641 cases). The RR(Q5vsQ1) of lobular tumors was 0.66 (95% CI: 0.44, 0.97; P for trend: 0.04), and the RR(Q5vsQ1) of ductal tumors was 0.90 (95% CI: 0.77, 1.04; P for trend: 0.10). Fiber from grains, fruit, vegetables, and beans was not related to breast cancer.

CONCLUSION

Our findings suggest that dietary fiber can play a role in preventing breast cancer through nonestrogen pathways among postmenopausal women.

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  • Authors+Show Affiliations

    ,

    Divisions of Cancer Epidemiology and Genetics and Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA. parkyik@mail.nih.gov

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    Source

    MeSH

    Aged
    Breast Neoplasms
    Carcinoma, Ductal
    Carcinoma, Lobular
    Diet
    Diet Surveys
    Dietary Fiber
    Edible Grain
    Fabaceae
    Female
    Follow-Up Studies
    Fruit
    Humans
    Middle Aged
    Postmenopause
    Proportional Hazards Models
    Receptors, Estrogen
    Receptors, Progesterone
    Risk Factors
    Surveys and Questionnaires
    United States
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    19625685

    Citation

    Park, Yikyung, et al. "Dietary Fiber Intake and Risk of Breast Cancer in Postmenopausal Women: the National Institutes of Health-AARP Diet and Health Study." The American Journal of Clinical Nutrition, vol. 90, no. 3, 2009, pp. 664-71.
    Park Y, Brinton LA, Subar AF, et al. Dietary fiber intake and risk of breast cancer in postmenopausal women: the National Institutes of Health-AARP Diet and Health Study. Am J Clin Nutr. 2009;90(3):664-71.
    Park, Y., Brinton, L. A., Subar, A. F., Hollenbeck, A., & Schatzkin, A. (2009). Dietary fiber intake and risk of breast cancer in postmenopausal women: the National Institutes of Health-AARP Diet and Health Study. The American Journal of Clinical Nutrition, 90(3), pp. 664-71. doi:10.3945/ajcn.2009.27758.
    Park Y, et al. Dietary Fiber Intake and Risk of Breast Cancer in Postmenopausal Women: the National Institutes of Health-AARP Diet and Health Study. Am J Clin Nutr. 2009;90(3):664-71. PubMed PMID: 19625685.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fiber intake and risk of breast cancer in postmenopausal women: the National Institutes of Health-AARP Diet and Health Study. AU - Park,Yikyung, AU - Brinton,Louise A, AU - Subar,Amy F, AU - Hollenbeck,Albert, AU - Schatzkin,Arthur, Y1 - 2009/07/22/ PY - 2009/7/24/entrez PY - 2009/7/25/pubmed PY - 2009/9/30/medline SP - 664 EP - 71 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 90 IS - 3 N2 - BACKGROUND: Although dietary fiber has been hypothesized to lower risk of breast cancer by modulating estrogen metabolism, the association between dietary fiber intake and risk of breast cancer by hormone receptor status is unclear. OBJECTIVE: The objective was to examine the relation of dietary fiber intake to breast cancer by hormone receptor status and histologic type among postmenopausal women in the National Institutes of Health-AARP Diet and Health Study (n = 185,598; mean age: 62 y). DESIGN: Dietary intakes were assessed with a food-frequency questionnaire. Incident breast cancer cases were identified through linkage with state cancer registries. Cox proportional hazard models were used to estimate relative risks (RRs) and 2-sided 95% CIs. RESULTS: During an average of 7 y of follow-up, 5461 breast cancer cases were identified, of which 3341 cases had estrogen receptor (ER) and progesterone receptor (PR) status. Dietary fiber intake was inversely associated with breast cancer risk [RR for the highest quintile (Q5) compared with the lowest quintile (Q1): 0.87; 95% CI: 0.77, 0.98; P for trend: 0.02]. The inverse association appeared to be stronger for ER(-)/PR(-) tumors (RR(Q5vsQ1): 0.56; 95% CI: 0.35, 0.90; P for trend: 0.008; 366 cases) than for ER(+)/PR(+) tumors (RR(Q5vsQ1): 0.95; 95% CI: 0.76, 1.20; P for trend: 0.47; 1641 cases). The RR(Q5vsQ1) of lobular tumors was 0.66 (95% CI: 0.44, 0.97; P for trend: 0.04), and the RR(Q5vsQ1) of ductal tumors was 0.90 (95% CI: 0.77, 1.04; P for trend: 0.10). Fiber from grains, fruit, vegetables, and beans was not related to breast cancer. CONCLUSION: Our findings suggest that dietary fiber can play a role in preventing breast cancer through nonestrogen pathways among postmenopausal women. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19625685/Dietary_fiber_intake_and_risk_of_breast_cancer_in_postmenopausal_women:_the_National_Institutes_of_Health_AARP_Diet_and_Health_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.27758 DB - PRIME DP - Unbound Medicine ER -