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Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men.

Abstract

Investigations suggest a protective role of n-3 polyunsaturated fatty acids (PUFA) but opposing roles of n-6 PUFA in inflammation, but the effects in vivo the human are not clear. We therefore tested the hypothesis that higher intakes of n-3 PUFA and n-6 PUFA are associated with lower levels of inflammation among a population consuming a diet high in PUFA. This study aimed to assess the association between PUFA intake and serum C-reactive protein (CRP) concentrations in a group of Japanese employees. The study subjects were 300 men and 211 women aged 21 to 67 years working in 2 municipal offices of Japan. We measured the serum high-sensitivity CRP concentrations by the latex agglutination nephelometry method and assessed dietary habits by a validated self-administered diet history questionnaire. We analyzed the data using multiple linear regression analysis with adjustment for potential confounding variables. Mean serum CRP concentrations tended to decrease as the intake of eicosapentaenoic acid, docosahexaenoic acid, or their combination increased in men and women, although none of these relationships was statistically significant. In men, there were statistically significant inverse relationships between dietary intake of n-3 or n-6 PUFA and serum CRP concentrations (P for trend = .03 and .008, respectively). Among specific PUFA, only alpha-linolenic acid and linoleic acid showed clear inverse relationships (P for trend = .001 and .003, respectively) in men. The results suggest that increased intake of not only alpha-linolenic acid (n-3 PUFA) but also linoleic acid (n-6 PUFA) has a beneficial effect on systemic inflammation in men.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan. kalpana@ri.imcj.go.jp

    , , , , ,

    Source

    Nutrition research (New York, N.Y.) 29:6 2009 Jun pg 363-70

    MeSH

    Adult
    Age Factors
    Aged
    Alcoholic Beverages
    Biomarkers
    Body Mass Index
    C-Reactive Protein
    Cardiovascular Diseases
    Cross-Sectional Studies
    Diet
    Diet Surveys
    Dietary Fats, Unsaturated
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Female
    Humans
    Inflammation
    Japan
    Linoleic Acid
    Male
    Middle Aged
    Motor Activity
    Multivariate Analysis
    Selection Bias
    Sex Characteristics
    Smoking
    Surveys and Questionnaires
    alpha-Linolenic Acid

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19628101

    Citation

    Poudel-Tandukar, Kalpana, et al. "Dietary Intakes of Alpha-linolenic and Linoleic Acids Are Inversely Associated With Serum C-reactive Protein Levels Among Japanese Men." Nutrition Research (New York, N.Y.), vol. 29, no. 6, 2009, pp. 363-70.
    Poudel-Tandukar K, Nanri A, Matsushita Y, et al. Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. Nutr Res. 2009;29(6):363-70.
    Poudel-Tandukar, K., Nanri, A., Matsushita, Y., Sasaki, S., Ohta, M., Sato, M., & Mizoue, T. (2009). Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. Nutrition Research (New York, N.Y.), 29(6), pp. 363-70. doi:10.1016/j.nutres.2009.05.012.
    Poudel-Tandukar K, et al. Dietary Intakes of Alpha-linolenic and Linoleic Acids Are Inversely Associated With Serum C-reactive Protein Levels Among Japanese Men. Nutr Res. 2009;29(6):363-70. PubMed PMID: 19628101.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. AU - Poudel-Tandukar,Kalpana, AU - Nanri,Akiko, AU - Matsushita,Yumi, AU - Sasaki,Satoshi, AU - Ohta,Masanori, AU - Sato,Masao, AU - Mizoue,Tetsuya, PY - 2009/04/06/received PY - 2009/05/26/revised PY - 2009/05/28/accepted PY - 2009/7/25/entrez PY - 2009/7/25/pubmed PY - 2009/9/15/medline SP - 363 EP - 70 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 29 IS - 6 N2 - Investigations suggest a protective role of n-3 polyunsaturated fatty acids (PUFA) but opposing roles of n-6 PUFA in inflammation, but the effects in vivo the human are not clear. We therefore tested the hypothesis that higher intakes of n-3 PUFA and n-6 PUFA are associated with lower levels of inflammation among a population consuming a diet high in PUFA. This study aimed to assess the association between PUFA intake and serum C-reactive protein (CRP) concentrations in a group of Japanese employees. The study subjects were 300 men and 211 women aged 21 to 67 years working in 2 municipal offices of Japan. We measured the serum high-sensitivity CRP concentrations by the latex agglutination nephelometry method and assessed dietary habits by a validated self-administered diet history questionnaire. We analyzed the data using multiple linear regression analysis with adjustment for potential confounding variables. Mean serum CRP concentrations tended to decrease as the intake of eicosapentaenoic acid, docosahexaenoic acid, or their combination increased in men and women, although none of these relationships was statistically significant. In men, there were statistically significant inverse relationships between dietary intake of n-3 or n-6 PUFA and serum CRP concentrations (P for trend = .03 and .008, respectively). Among specific PUFA, only alpha-linolenic acid and linoleic acid showed clear inverse relationships (P for trend = .001 and .003, respectively) in men. The results suggest that increased intake of not only alpha-linolenic acid (n-3 PUFA) but also linoleic acid (n-6 PUFA) has a beneficial effect on systemic inflammation in men. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19628101/Dietary_intakes_of_alpha_linolenic_and_linoleic_acids_are_inversely_associated_with_serum_C_reactive_protein_levels_among_Japanese_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(09)00090-6 DB - PRIME DP - Unbound Medicine ER -