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Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men.
Nutr Res 2009; 29(6):363-70NR

Abstract

Investigations suggest a protective role of n-3 polyunsaturated fatty acids (PUFA) but opposing roles of n-6 PUFA in inflammation, but the effects in vivo the human are not clear. We therefore tested the hypothesis that higher intakes of n-3 PUFA and n-6 PUFA are associated with lower levels of inflammation among a population consuming a diet high in PUFA. This study aimed to assess the association between PUFA intake and serum C-reactive protein (CRP) concentrations in a group of Japanese employees. The study subjects were 300 men and 211 women aged 21 to 67 years working in 2 municipal offices of Japan. We measured the serum high-sensitivity CRP concentrations by the latex agglutination nephelometry method and assessed dietary habits by a validated self-administered diet history questionnaire. We analyzed the data using multiple linear regression analysis with adjustment for potential confounding variables. Mean serum CRP concentrations tended to decrease as the intake of eicosapentaenoic acid, docosahexaenoic acid, or their combination increased in men and women, although none of these relationships was statistically significant. In men, there were statistically significant inverse relationships between dietary intake of n-3 or n-6 PUFA and serum CRP concentrations (P for trend = .03 and .008, respectively). Among specific PUFA, only alpha-linolenic acid and linoleic acid showed clear inverse relationships (P for trend = .001 and .003, respectively) in men. The results suggest that increased intake of not only alpha-linolenic acid (n-3 PUFA) but also linoleic acid (n-6 PUFA) has a beneficial effect on systemic inflammation in men.

Authors+Show Affiliations

Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan. kalpana@ri.imcj.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19628101

Citation

Poudel-Tandukar, Kalpana, et al. "Dietary Intakes of Alpha-linolenic and Linoleic Acids Are Inversely Associated With Serum C-reactive Protein Levels Among Japanese Men." Nutrition Research (New York, N.Y.), vol. 29, no. 6, 2009, pp. 363-70.
Poudel-Tandukar K, Nanri A, Matsushita Y, et al. Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. Nutr Res. 2009;29(6):363-70.
Poudel-Tandukar, K., Nanri, A., Matsushita, Y., Sasaki, S., Ohta, M., Sato, M., & Mizoue, T. (2009). Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. Nutrition Research (New York, N.Y.), 29(6), pp. 363-70. doi:10.1016/j.nutres.2009.05.012.
Poudel-Tandukar K, et al. Dietary Intakes of Alpha-linolenic and Linoleic Acids Are Inversely Associated With Serum C-reactive Protein Levels Among Japanese Men. Nutr Res. 2009;29(6):363-70. PubMed PMID: 19628101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. AU - Poudel-Tandukar,Kalpana, AU - Nanri,Akiko, AU - Matsushita,Yumi, AU - Sasaki,Satoshi, AU - Ohta,Masanori, AU - Sato,Masao, AU - Mizoue,Tetsuya, PY - 2009/04/06/received PY - 2009/05/26/revised PY - 2009/05/28/accepted PY - 2009/7/25/entrez PY - 2009/7/25/pubmed PY - 2009/9/15/medline SP - 363 EP - 70 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 29 IS - 6 N2 - Investigations suggest a protective role of n-3 polyunsaturated fatty acids (PUFA) but opposing roles of n-6 PUFA in inflammation, but the effects in vivo the human are not clear. We therefore tested the hypothesis that higher intakes of n-3 PUFA and n-6 PUFA are associated with lower levels of inflammation among a population consuming a diet high in PUFA. This study aimed to assess the association between PUFA intake and serum C-reactive protein (CRP) concentrations in a group of Japanese employees. The study subjects were 300 men and 211 women aged 21 to 67 years working in 2 municipal offices of Japan. We measured the serum high-sensitivity CRP concentrations by the latex agglutination nephelometry method and assessed dietary habits by a validated self-administered diet history questionnaire. We analyzed the data using multiple linear regression analysis with adjustment for potential confounding variables. Mean serum CRP concentrations tended to decrease as the intake of eicosapentaenoic acid, docosahexaenoic acid, or their combination increased in men and women, although none of these relationships was statistically significant. In men, there were statistically significant inverse relationships between dietary intake of n-3 or n-6 PUFA and serum CRP concentrations (P for trend = .03 and .008, respectively). Among specific PUFA, only alpha-linolenic acid and linoleic acid showed clear inverse relationships (P for trend = .001 and .003, respectively) in men. The results suggest that increased intake of not only alpha-linolenic acid (n-3 PUFA) but also linoleic acid (n-6 PUFA) has a beneficial effect on systemic inflammation in men. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19628101/Dietary_intakes_of_alpha_linolenic_and_linoleic_acids_are_inversely_associated_with_serum_C_reactive_protein_levels_among_Japanese_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(09)00090-6 DB - PRIME DP - Unbound Medicine ER -