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Effect of fluvastatin on progression of coronary atherosclerotic plaque evaluated by virtual histology intravascular ultrasound.
JACC Cardiovasc Interv. 2009 Jul; 2(7):689-96.JC

Abstract

OBJECTIVES

The aim of this study was to evaluate the effect of treatment with statins on the progression of coronary atherosclerotic plaques of a nonculprit vessel by serial volumetric virtual histology (VH) intravascular ultrasound (IVUS).

BACKGROUND

Recent clinical trials have demonstrated a reduction of atherosclerotic plaque, yet whether statin therapy affects the change in components of plaque remains unknown.

METHODS

This study was a nonrandomized and nonblinded design. Eighty patients with stable angina pectoris were divided into either the fluvastatin group (n = 40) or the control group (n = 40) according to their total or low-density lipoprotein (LDL) cholesterol level. The volume of each plaque component (dense calcium, fibrous tissue, fibro-fatty, or necrotic core) was evaluated at baseline and at 12-month follow-up.

RESULTS

The LDL cholesterol and high-sensitivity C-reactive protein (hsCRP) levels in the fluvastatin group were significantly decreased at time of follow-up. In VH IVUS findings, fibro-fatty volume was significantly decreased (baseline 80.1 +/- 57.9 mm(3) vs. follow-up 32.5 +/- 27.7 mm(3), p < 0.0001) and fibrous tissue volume was increased (baseline 146.5 +/- 85.6 mm(3) vs. follow-up 163.3 +/- 94.5 mm(3), p < 0.0001) in the fluvastatin group. In the control group, the volumes of all plaque components without fibrous tissue were significantly increased. Change in fibro-fatty volume has a significant correlation with a change in LDL cholesterol level (R = 0.703, p < 0.0001) and change in hsCRP level (R = 0.357, p = 0.006).

CONCLUSIONS

One-year lipid-lowering therapy by fluvastatin showed significant regression of plaque volume and alterations in atherosclerotic plaque composition with a significant reduction of fibro-fatty volume.

Authors+Show Affiliations

Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan. nasu@heartcenter.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

19628194

Citation

Nasu, Kenya, et al. "Effect of Fluvastatin On Progression of Coronary Atherosclerotic Plaque Evaluated By Virtual Histology Intravascular Ultrasound." JACC. Cardiovascular Interventions, vol. 2, no. 7, 2009, pp. 689-96.
Nasu K, Tsuchikane E, Katoh O, et al. Effect of fluvastatin on progression of coronary atherosclerotic plaque evaluated by virtual histology intravascular ultrasound. JACC Cardiovasc Interv. 2009;2(7):689-96.
Nasu, K., Tsuchikane, E., Katoh, O., Tanaka, N., Kimura, M., Ehara, M., Kinoshita, Y., Matsubara, T., Matsuo, H., Asakura, K., Asakura, Y., Terashima, M., Takayama, T., Honye, J., Hirayama, A., Saito, S., & Suzuki, T. (2009). Effect of fluvastatin on progression of coronary atherosclerotic plaque evaluated by virtual histology intravascular ultrasound. JACC. Cardiovascular Interventions, 2(7), 689-96. https://doi.org/10.1016/j.jcin.2009.04.016
Nasu K, et al. Effect of Fluvastatin On Progression of Coronary Atherosclerotic Plaque Evaluated By Virtual Histology Intravascular Ultrasound. JACC Cardiovasc Interv. 2009;2(7):689-96. PubMed PMID: 19628194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fluvastatin on progression of coronary atherosclerotic plaque evaluated by virtual histology intravascular ultrasound. AU - Nasu,Kenya, AU - Tsuchikane,Etsuo, AU - Katoh,Osamu, AU - Tanaka,Nobuyoshi, AU - Kimura,Masashi, AU - Ehara,Mariko, AU - Kinoshita,Yoshihisa, AU - Matsubara,Tetsuo, AU - Matsuo,Hitoshi, AU - Asakura,Keiko, AU - Asakura,Yasushi, AU - Terashima,Mitsuyasu, AU - Takayama,Tadateru, AU - Honye,Junko, AU - Hirayama,Atsushi, AU - Saito,Satoshi, AU - Suzuki,Takahiko, PY - 2009/04/06/received PY - 2009/04/19/accepted PY - 2009/7/25/entrez PY - 2009/7/25/pubmed PY - 2009/10/3/medline SP - 689 EP - 96 JF - JACC. Cardiovascular interventions JO - JACC Cardiovasc Interv VL - 2 IS - 7 N2 - OBJECTIVES: The aim of this study was to evaluate the effect of treatment with statins on the progression of coronary atherosclerotic plaques of a nonculprit vessel by serial volumetric virtual histology (VH) intravascular ultrasound (IVUS). BACKGROUND: Recent clinical trials have demonstrated a reduction of atherosclerotic plaque, yet whether statin therapy affects the change in components of plaque remains unknown. METHODS: This study was a nonrandomized and nonblinded design. Eighty patients with stable angina pectoris were divided into either the fluvastatin group (n = 40) or the control group (n = 40) according to their total or low-density lipoprotein (LDL) cholesterol level. The volume of each plaque component (dense calcium, fibrous tissue, fibro-fatty, or necrotic core) was evaluated at baseline and at 12-month follow-up. RESULTS: The LDL cholesterol and high-sensitivity C-reactive protein (hsCRP) levels in the fluvastatin group were significantly decreased at time of follow-up. In VH IVUS findings, fibro-fatty volume was significantly decreased (baseline 80.1 +/- 57.9 mm(3) vs. follow-up 32.5 +/- 27.7 mm(3), p < 0.0001) and fibrous tissue volume was increased (baseline 146.5 +/- 85.6 mm(3) vs. follow-up 163.3 +/- 94.5 mm(3), p < 0.0001) in the fluvastatin group. In the control group, the volumes of all plaque components without fibrous tissue were significantly increased. Change in fibro-fatty volume has a significant correlation with a change in LDL cholesterol level (R = 0.703, p < 0.0001) and change in hsCRP level (R = 0.357, p = 0.006). CONCLUSIONS: One-year lipid-lowering therapy by fluvastatin showed significant regression of plaque volume and alterations in atherosclerotic plaque composition with a significant reduction of fibro-fatty volume. SN - 1876-7605 UR - https://www.unboundmedicine.com/medline/citation/19628194/Effect_of_fluvastatin_on_progression_of_coronary_atherosclerotic_plaque_evaluated_by_virtual_histology_intravascular_ultrasound_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1936-8798(09)00325-2 DB - PRIME DP - Unbound Medicine ER -