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Dietary glycemic index is inversely associated with the risk of Parkinson's disease: a case-control study in Japan.

Abstract

OBJECTIVE

High glycemic index (GI) or glycemic load (GL) carbohydrates might be expected to decrease the risk of Parkinson's disease (PD) by an insulin-induced increase in brain dopamine. We conducted a hospital-based case-control study in Japan to examine associations between dietary GI and GL and other dietary carbohydrate variables, including intake of available carbohydrate and dietary fiber, and PD.

METHODS

Patients with PD diagnosed using the U.K. Parkinson's Disease Society Brain Bank criteria (n=249) and controls without neurodegenerative diseases (n=368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semiquantitative, comprehensive diet history questionnaire.

RESULTS

After adjustment for potential dietary and non-dietary confounding factors, dietary GI was significantly inversely associated with the risk of PD. Multivariate odds ratios (95% confidence intervals) for PD in the first, second, third, and fourth quartiles of dietary GI were 1.00 (reference), 1.03 (0.64-1.66), 0.68 (0.41-1.15), and 0.61 (0.34-1.09), respectively (P for trend=0.04). Conversely, no significant association was observed for other dietary carbohydrates, including dietary GL (P for trend=0.77), available carbohydrate intake (P for trend=0.28), or dietary fiber intake (P for trend=0.73).

CONCLUSION

This preliminary case-control study based on current dietary habits found an independent inverse relation between dietary GI and PD. Considering the plausibility of the putative mechanism, further investigation using a case-control design with accurate assessment of past dietary habits or a prospective design is warranted.

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  • Authors+Show Affiliations

    ,

    Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo, Tokyo, Japan.

    , , , , , , , , , , , , , ,

    Source

    MeSH

    Aged
    Case-Control Studies
    Diet
    Diet Records
    Dietary Carbohydrates
    Dietary Fiber
    Female
    Glycemic Index
    Hospitals
    Humans
    Japan
    Male
    Middle Aged
    Odds Ratio
    Parkinson Disease
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19628370

    Citation

    Murakami, Kentaro, et al. "Dietary Glycemic Index Is Inversely Associated With the Risk of Parkinson's Disease: a Case-control Study in Japan." Nutrition (Burbank, Los Angeles County, Calif.), vol. 26, no. 5, 2010, pp. 515-21.
    Murakami K, Miyake Y, Sasaki S, et al. Dietary glycemic index is inversely associated with the risk of Parkinson's disease: a case-control study in Japan. Nutrition. 2010;26(5):515-21.
    Murakami, K., Miyake, Y., Sasaki, S., Tanaka, K., Fukushima, W., Kiyohara, C., ... Nagai, M. (2010). Dietary glycemic index is inversely associated with the risk of Parkinson's disease: a case-control study in Japan. Nutrition (Burbank, Los Angeles County, Calif.), 26(5), pp. 515-21. doi:10.1016/j.nut.2009.05.021.
    Murakami K, et al. Dietary Glycemic Index Is Inversely Associated With the Risk of Parkinson's Disease: a Case-control Study in Japan. Nutrition. 2010;26(5):515-21. PubMed PMID: 19628370.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary glycemic index is inversely associated with the risk of Parkinson's disease: a case-control study in Japan. AU - Murakami,Kentaro, AU - Miyake,Yoshihiro, AU - Sasaki,Satoshi, AU - Tanaka,Keiko, AU - Fukushima,Wakaba, AU - Kiyohara,Chikako, AU - Tsuboi,Yoshio, AU - Yamada,Tatsuo, AU - Oeda,Tomoko, AU - Miki,Takami, AU - Kawamura,Nobutoshi, AU - Sakae,Nobutaka, AU - Fukuyama,Hidenao, AU - Hirota,Yoshio, AU - Nagai,Masaki, AU - ,, Y1 - 2009/07/22/ PY - 2009/01/15/received PY - 2009/05/29/revised PY - 2009/05/29/accepted PY - 2009/7/25/entrez PY - 2009/7/25/pubmed PY - 2010/6/29/medline SP - 515 EP - 21 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 26 IS - 5 N2 - OBJECTIVE: High glycemic index (GI) or glycemic load (GL) carbohydrates might be expected to decrease the risk of Parkinson's disease (PD) by an insulin-induced increase in brain dopamine. We conducted a hospital-based case-control study in Japan to examine associations between dietary GI and GL and other dietary carbohydrate variables, including intake of available carbohydrate and dietary fiber, and PD. METHODS: Patients with PD diagnosed using the U.K. Parkinson's Disease Society Brain Bank criteria (n=249) and controls without neurodegenerative diseases (n=368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semiquantitative, comprehensive diet history questionnaire. RESULTS: After adjustment for potential dietary and non-dietary confounding factors, dietary GI was significantly inversely associated with the risk of PD. Multivariate odds ratios (95% confidence intervals) for PD in the first, second, third, and fourth quartiles of dietary GI were 1.00 (reference), 1.03 (0.64-1.66), 0.68 (0.41-1.15), and 0.61 (0.34-1.09), respectively (P for trend=0.04). Conversely, no significant association was observed for other dietary carbohydrates, including dietary GL (P for trend=0.77), available carbohydrate intake (P for trend=0.28), or dietary fiber intake (P for trend=0.73). CONCLUSION: This preliminary case-control study based on current dietary habits found an independent inverse relation between dietary GI and PD. Considering the plausibility of the putative mechanism, further investigation using a case-control design with accurate assessment of past dietary habits or a prospective design is warranted. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/19628370/Dietary_glycemic_index_is_inversely_associated_with_the_risk_of_Parkinson's_disease:_a_case_control_study_in_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(09)00242-1 DB - PRIME DP - Unbound Medicine ER -