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Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes.
Eur J Endocrinol. 2009 Oct; 161(4):567-73.EJ

Abstract

OBJECTIVE

To investigate the effects of unacylated ghrelin (UAG) and co-administration of acylated ghrelin (AG) and UAG in morbid obesity, a condition characterized by insulin resistance and low GH levels.

DESIGN AND METHOD

Eight morbidly obese non-diabetic subjects were treated with either UAG 200 microg, UAG 100 microg in combination with AG 100 microg (Comb) or placebo in three episodes of 4 consecutive days in a double-blind randomized crossover design. Study medication was administered as daily single i.v. bolus injections at 0900 h after an overnight fast. At 1000 h, a standardized meal was served. Glucose, insulin, GH, free fatty acids (FFA) and ghrelin were measured up to 4 h after administration.

RESULTS

Insulin concentrations significantly decreased after acute administration of Comb only, reaching a minimum at 20 min: 58.2 + or - 3.9% of baseline versus 88.7 + or - 7.2 and 92.7 + or - 2.6% after administration of placebo and UAG respectively (P<0.01). After 1 h, insulin concentration had returned to baseline. Glucose concentrations did not change after Comb. However, UAG administration alone did not change glucose, insulin, FFA or GH levels.

CONCLUSION

Co-administration of AG and UAG as a single i.v. bolus injection causes a significant decrease in insulin concentration in non-diabetic subjects suffering from morbid obesity. Since glucose concentration did not change in the first hour after Comb administration, our data suggest a strong improvement in insulin sensitivity. These findings warrant studies in which UAG with or without AG is administered for a longer period of time. Administration of a single bolus injection of UAG did not influence glucose and insulin metabolism.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Molinette Hospital, Corso Dogliotti 14, 10126, Turin, Italy. r.kiewiet@erasmusmc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19628651

Citation

Kiewiet, Rosalie M., et al. "Effects of Acute Administration of Acylated and Unacylated Ghrelin On Glucose and Insulin Concentrations in Morbidly Obese Subjects Without Overt Diabetes." European Journal of Endocrinology, vol. 161, no. 4, 2009, pp. 567-73.
Kiewiet RM, van Aken MO, van der Weerd K, et al. Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes. Eur J Endocrinol. 2009;161(4):567-73.
Kiewiet, R. M., van Aken, M. O., van der Weerd, K., Uitterlinden, P., Themmen, A. P., Hofland, L. J., de Rijke, Y. B., Delhanty, P. J., Ghigo, E., Abribat, T., & van der Lely, A. J. (2009). Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes. European Journal of Endocrinology, 161(4), 567-73. https://doi.org/10.1530/EJE-09-0339
Kiewiet RM, et al. Effects of Acute Administration of Acylated and Unacylated Ghrelin On Glucose and Insulin Concentrations in Morbidly Obese Subjects Without Overt Diabetes. Eur J Endocrinol. 2009;161(4):567-73. PubMed PMID: 19628651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes. AU - Kiewiet,Rosalie M, AU - van Aken,Maarten O, AU - van der Weerd,Kim, AU - Uitterlinden,Piet, AU - Themmen,Axel P N, AU - Hofland,Leo J, AU - de Rijke,Yolanda B, AU - Delhanty,Patric J D, AU - Ghigo,Ezio, AU - Abribat,Thierry, AU - van der Lely,Aart Jan, Y1 - 2009/07/23/ PY - 2009/7/25/entrez PY - 2009/7/25/pubmed PY - 2009/10/6/medline SP - 567 EP - 73 JF - European journal of endocrinology JO - Eur J Endocrinol VL - 161 IS - 4 N2 - OBJECTIVE: To investigate the effects of unacylated ghrelin (UAG) and co-administration of acylated ghrelin (AG) and UAG in morbid obesity, a condition characterized by insulin resistance and low GH levels. DESIGN AND METHOD: Eight morbidly obese non-diabetic subjects were treated with either UAG 200 microg, UAG 100 microg in combination with AG 100 microg (Comb) or placebo in three episodes of 4 consecutive days in a double-blind randomized crossover design. Study medication was administered as daily single i.v. bolus injections at 0900 h after an overnight fast. At 1000 h, a standardized meal was served. Glucose, insulin, GH, free fatty acids (FFA) and ghrelin were measured up to 4 h after administration. RESULTS: Insulin concentrations significantly decreased after acute administration of Comb only, reaching a minimum at 20 min: 58.2 + or - 3.9% of baseline versus 88.7 + or - 7.2 and 92.7 + or - 2.6% after administration of placebo and UAG respectively (P<0.01). After 1 h, insulin concentration had returned to baseline. Glucose concentrations did not change after Comb. However, UAG administration alone did not change glucose, insulin, FFA or GH levels. CONCLUSION: Co-administration of AG and UAG as a single i.v. bolus injection causes a significant decrease in insulin concentration in non-diabetic subjects suffering from morbid obesity. Since glucose concentration did not change in the first hour after Comb administration, our data suggest a strong improvement in insulin sensitivity. These findings warrant studies in which UAG with or without AG is administered for a longer period of time. Administration of a single bolus injection of UAG did not influence glucose and insulin metabolism. SN - 1479-683X UR - https://www.unboundmedicine.com/medline/citation/19628651/Effects_of_acute_administration_of_acylated_and_unacylated_ghrelin_on_glucose_and_insulin_concentrations_in_morbidly_obese_subjects_without_overt_diabetes_ L2 - https://eje.bioscientifica.com/doi/10.1530/EJE-09-0339 DB - PRIME DP - Unbound Medicine ER -