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Respective contribution of conventional risk factors and antihypertensive treatment to stable angina pectoris and acute coronary syndrome as the first presentation of coronary heart disease: the PRIME Study.
Eur J Cardiovasc Prev Rehabil 2009; 16(5):550-5EJ

Abstract

OBJECTIVE

To test whether conventional risk factors and antihypertensive treatment were more predictive of stable angina (SA) than acute coronary syndrome (ACS) as the first presentation of coronary heart disease (CHD).

DESIGN

We used data from the PRIME Study (Prospective Epidemiological Study of Myocardial Infarction), a prospective cohort of 9758 asymptomatic middle-aged men recruited from WHO MONICA centers in Northern Ireland and France between 1991 and 1993. SA and ACS events were registered during 5 years of follow-up.

METHODS

Hazard ratios (HRs) of each risk factor measured at baseline for SA and ACS events were assessed using separate Cox proportional hazard models. Difference between HRs was estimated by the bootstrap method.

RESULTS

After 5 years of follow-up, there were 114 SA and 178 ACS as the first presentation of CHD. Diastolic blood pressure [adjusted HRs for 1 standard deviation increase = 1.34; 95% confidence interval (CI): 1.17-1.54 vs. 1.04; 95% CI: 0.87-1.25; P for comparison between HRs = 0.012], and possibly cigarette smoking over or equal to 20 pack-years (adjusted HR = 2.07; 95% CI: 1.43-2.99 vs. 1.29; 95% CI: 0.83-2.01; P for comparison between HRs = 0.062) were more predictive of ACS than SA, whereas this was the opposite for antihypertensive treatment (adjusted HR = 2.18; 95% CI: 1.39-3.41 for SA vs. 1.28; 95% CI: 0.85-1.93 for ACS, P for comparison between HRs = 0.049).

CONCLUSION

The present data support that SA and ACS, as the first presentation of CHD, may not share exactly the same determinants.

Authors+Show Affiliations

INSERM, U970, Paris Cardiovascular Research Centre (PAARC), Université Paris V, Paris , France. florence.canoui-poitrine@chu-lyon.fr

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19629011

Citation

Canoui-Poitrine, Florence, et al. "Respective Contribution of Conventional Risk Factors and Antihypertensive Treatment to Stable Angina Pectoris and Acute Coronary Syndrome as the First Presentation of Coronary Heart Disease: the PRIME Study." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 16, no. 5, 2009, pp. 550-5.
Canoui-Poitrine F, Luc G, Juhan-Vague I, et al. Respective contribution of conventional risk factors and antihypertensive treatment to stable angina pectoris and acute coronary syndrome as the first presentation of coronary heart disease: the PRIME Study. Eur J Cardiovasc Prev Rehabil. 2009;16(5):550-5.
Canoui-Poitrine, F., Luc, G., Juhan-Vague, I., Morange, P. E., Arveiler, D., Ferrieres, J., ... Empana, J. P. (2009). Respective contribution of conventional risk factors and antihypertensive treatment to stable angina pectoris and acute coronary syndrome as the first presentation of coronary heart disease: the PRIME Study. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 16(5), pp. 550-5. doi:10.1097/HJR.0b013e32832c88d1.
Canoui-Poitrine F, et al. Respective Contribution of Conventional Risk Factors and Antihypertensive Treatment to Stable Angina Pectoris and Acute Coronary Syndrome as the First Presentation of Coronary Heart Disease: the PRIME Study. Eur J Cardiovasc Prev Rehabil. 2009;16(5):550-5. PubMed PMID: 19629011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respective contribution of conventional risk factors and antihypertensive treatment to stable angina pectoris and acute coronary syndrome as the first presentation of coronary heart disease: the PRIME Study. AU - Canoui-Poitrine,Florence, AU - Luc,Gerald, AU - Juhan-Vague,Irène, AU - Morange,Pierre-Emmanuel, AU - Arveiler,Dominique, AU - Ferrieres,Jean, AU - Amouyel,Philippe, AU - Bingham,Annie, AU - Montaye,Michèle, AU - Ruidavets,Jean-Bernard, AU - Haas,Bernadette, AU - Evans,Alun, AU - Ducimetiere,Pierre, AU - Empana,Jean-Philippe, AU - ,, PY - 2009/7/25/entrez PY - 2009/7/25/pubmed PY - 2010/3/12/medline SP - 550 EP - 5 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 16 IS - 5 N2 - OBJECTIVE: To test whether conventional risk factors and antihypertensive treatment were more predictive of stable angina (SA) than acute coronary syndrome (ACS) as the first presentation of coronary heart disease (CHD). DESIGN: We used data from the PRIME Study (Prospective Epidemiological Study of Myocardial Infarction), a prospective cohort of 9758 asymptomatic middle-aged men recruited from WHO MONICA centers in Northern Ireland and France between 1991 and 1993. SA and ACS events were registered during 5 years of follow-up. METHODS: Hazard ratios (HRs) of each risk factor measured at baseline for SA and ACS events were assessed using separate Cox proportional hazard models. Difference between HRs was estimated by the bootstrap method. RESULTS: After 5 years of follow-up, there were 114 SA and 178 ACS as the first presentation of CHD. Diastolic blood pressure [adjusted HRs for 1 standard deviation increase = 1.34; 95% confidence interval (CI): 1.17-1.54 vs. 1.04; 95% CI: 0.87-1.25; P for comparison between HRs = 0.012], and possibly cigarette smoking over or equal to 20 pack-years (adjusted HR = 2.07; 95% CI: 1.43-2.99 vs. 1.29; 95% CI: 0.83-2.01; P for comparison between HRs = 0.062) were more predictive of ACS than SA, whereas this was the opposite for antihypertensive treatment (adjusted HR = 2.18; 95% CI: 1.39-3.41 for SA vs. 1.28; 95% CI: 0.85-1.93 for ACS, P for comparison between HRs = 0.049). CONCLUSION: The present data support that SA and ACS, as the first presentation of CHD, may not share exactly the same determinants. SN - 1741-8275 UR - https://www.unboundmedicine.com/medline/citation/19629011/Respective_contribution_of_conventional_risk_factors_and_antihypertensive_treatment_to_stable_angina_pectoris_and_acute_coronary_syndrome_as_the_first_presentation_of_coronary_heart_disease:_the_PRIME_Study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=19629011.ui DB - PRIME DP - Unbound Medicine ER -