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Phytocannabinoids and endocannabinoids.
Curr Drug Abuse Rev 2009; 2(1):51-75CD

Abstract

Progress in understanding the molecular mechanisms of cannabis action was made after discovery of cannabinoid receptors in the brain and the finding of endogenous metabolites with affinity to them. Activation of cannabinoid receptors on synaptic terminals results in regulation of ion channels, neurotransmitter release and synaptic plasticity. Neuromodulation of synapses by the cannabinoids is proving to have a wide range of functional effects, making them potential targets as medical preparations in a variety of illnesses, including some mental disorders and neurodegenerative illnesses. Cannabis contains a large amount of substances with affinity for the cannabinoid receptors. The endocannabinoids are a family of lipid neurotransmitters that engage the same membrane receptors targeted by tetrahydrocannabinol and that mediate retrograde signal from postsynaptic neurons to presynaptic ones. Discovery of endogenous cannabinoids and studies of the physiological functions of the cannabinoid system in the brain and body are producing a number of important findings about the role of membrane lipids and fatty acids in nerve signal transduction. Plant, endogenous and synthetic cannabinoids are using in these studies. The role of lipid membranes in the cannabinoid system follows from the fact that the source and supply of endogenous cannabinoids are derived from arachidonic acid, an important membrane constituent. The study of structure-activity relationships of molecules which influence the cannabinoid system in the brain and body is crucial in search of medical preparations with the therapeutic effects of the phytocannabinoids without the negative effects on cognitive function attributed to cannabis.

Authors+Show Affiliations

Department of Psychiatry, 1st Faculty of Medicine, Charles University in Prague, Ke Karlovu 11, 128 01 Prague 2, Czech Republic. zfisar@lf1.cuni.cz

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19630737

Citation

Fisar, Zdenek. "Phytocannabinoids and Endocannabinoids." Current Drug Abuse Reviews, vol. 2, no. 1, 2009, pp. 51-75.
Fisar Z. Phytocannabinoids and endocannabinoids. Curr Drug Abuse Rev. 2009;2(1):51-75.
Fisar, Z. (2009). Phytocannabinoids and endocannabinoids. Current Drug Abuse Reviews, 2(1), pp. 51-75.
Fisar Z. Phytocannabinoids and Endocannabinoids. Curr Drug Abuse Rev. 2009;2(1):51-75. PubMed PMID: 19630737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytocannabinoids and endocannabinoids. A1 - Fisar,Zdenek, PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2009/10/13/medline SP - 51 EP - 75 JF - Current drug abuse reviews JO - Curr Drug Abuse Rev VL - 2 IS - 1 N2 - Progress in understanding the molecular mechanisms of cannabis action was made after discovery of cannabinoid receptors in the brain and the finding of endogenous metabolites with affinity to them. Activation of cannabinoid receptors on synaptic terminals results in regulation of ion channels, neurotransmitter release and synaptic plasticity. Neuromodulation of synapses by the cannabinoids is proving to have a wide range of functional effects, making them potential targets as medical preparations in a variety of illnesses, including some mental disorders and neurodegenerative illnesses. Cannabis contains a large amount of substances with affinity for the cannabinoid receptors. The endocannabinoids are a family of lipid neurotransmitters that engage the same membrane receptors targeted by tetrahydrocannabinol and that mediate retrograde signal from postsynaptic neurons to presynaptic ones. Discovery of endogenous cannabinoids and studies of the physiological functions of the cannabinoid system in the brain and body are producing a number of important findings about the role of membrane lipids and fatty acids in nerve signal transduction. Plant, endogenous and synthetic cannabinoids are using in these studies. The role of lipid membranes in the cannabinoid system follows from the fact that the source and supply of endogenous cannabinoids are derived from arachidonic acid, an important membrane constituent. The study of structure-activity relationships of molecules which influence the cannabinoid system in the brain and body is crucial in search of medical preparations with the therapeutic effects of the phytocannabinoids without the negative effects on cognitive function attributed to cannabis. SN - 1874-4745 UR - https://www.unboundmedicine.com/medline/citation/19630737/Phytocannabinoids_and_endocannabinoids_ L2 - http://www.eurekaselect.com/93058/article DB - PRIME DP - Unbound Medicine ER -