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Phlebotomus perfiliewi transcaucasicus is circulating both Leishmania donovani and L. infantum in northwest Iran.
Exp Parasitol. 2009 Nov; 123(3):218-25.EP

Abstract

Leishmania infantum is the causative agent of infantile visceral leishmaniasis (IVL) in the Mediterranean Basin and, based on isoenzyme typing of the parasite isolated from dogs; this parasite was considered to predominate in the all foci of IVL in Iran. However, based on PCR detection and sequencing of parasite Cysteine Protease B (CPB), only one out of seven sandfly infections in Phlebotomus perfiliewi transcaucasicus was found to be L. infantum in the current investigation. The six other infections were haplotypes of Leishmania donovani, the causative agent of anthroponotic visceral leishmaniasis (AVL) in West Africa and India. The deduced amino acid of the L. donovani haplotype was found to be novel and the shortest CPB protein reported within the Leishmania spp. Circulation of both L. donovani and L. infantum by P. perfiliewi transcaucasicus, in addition to previous data indicating its ability to circulate L. tropica, suggests that this species, like other vectors of VL, is a permissive vector. Finding L. donovani infecting P. perfiliewi transcaucasicus in the area demands extensive and intensive typing of natural Leishmania infections in epidemiological investigations in Iran and the Mediterranean Basin in general.

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Authors+Show Affiliations

Oshaghi MA
Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Research, Tehran University of Medical Sciences, Tehran 14155-6446, Iran. moshaghi@sina.tums.ac.ir
Ravasan NM
No affiliation info available
Hide M
No affiliation info available
Javadian EA
No affiliation info available
Rassi Y
No affiliation info available
Sadraei J
No affiliation info available
Mohebali M
No affiliation info available
Sedaghat MM
No affiliation info available
Hajjaran H
No affiliation info available
Zarei Z
No affiliation info available
Mohtarami F
No affiliation info available

MeSH

Amino Acid SequenceAnimalsBase SequenceCysteine EndopeptidasesDNA, KinetoplastDNA, Ribosomal SpacerDogsFemaleHaplotypesHumansInsect VectorsIranLeishmania donovaniLeishmania infantumLeishmaniasis, VisceralMaleMolecular Sequence DataPhlebotomusPhylogenyPolymerase Chain ReactionPolymorphism, GeneticSequence Alignment

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19631209

Citation

Oshaghi, Mohammad Ali, et al. "Phlebotomus Perfiliewi Transcaucasicus Is Circulating Both Leishmania Donovani and L. Infantum in Northwest Iran." Experimental Parasitology, vol. 123, no. 3, 2009, pp. 218-25.
Oshaghi MA, Ravasan NM, Hide M, et al. Phlebotomus perfiliewi transcaucasicus is circulating both Leishmania donovani and L. infantum in northwest Iran. Exp Parasitol. 2009;123(3):218-25.
Oshaghi, M. A., Ravasan, N. M., Hide, M., Javadian, E. A., Rassi, Y., Sadraei, J., Mohebali, M., Sedaghat, M. M., Hajjaran, H., Zarei, Z., & Mohtarami, F. (2009). Phlebotomus perfiliewi transcaucasicus is circulating both Leishmania donovani and L. infantum in northwest Iran. Experimental Parasitology, 123(3), 218-25. https://doi.org/10.1016/j.exppara.2009.07.004
Oshaghi MA, et al. Phlebotomus Perfiliewi Transcaucasicus Is Circulating Both Leishmania Donovani and L. Infantum in Northwest Iran. Exp Parasitol. 2009;123(3):218-25. PubMed PMID: 19631209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phlebotomus perfiliewi transcaucasicus is circulating both Leishmania donovani and L. infantum in northwest Iran. AU - Oshaghi,Mohammad Ali, AU - Ravasan,Naseh Maleki, AU - Hide,Mallorie, AU - Javadian,Ezat-Aldin, AU - Rassi,Yavar, AU - Sadraei,Javid, AU - Mohebali,Mehdi, AU - Sedaghat,Mohammad Mehdi, AU - Hajjaran,Homa, AU - Zarei,Zabiholah, AU - Mohtarami,Fatemeh, Y1 - 2009/07/22/ PY - 2009/01/21/received PY - 2009/07/08/revised PY - 2009/07/14/accepted PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2009/9/19/medline SP - 218 EP - 25 JF - Experimental parasitology JO - Exp Parasitol VL - 123 IS - 3 N2 - Leishmania infantum is the causative agent of infantile visceral leishmaniasis (IVL) in the Mediterranean Basin and, based on isoenzyme typing of the parasite isolated from dogs; this parasite was considered to predominate in the all foci of IVL in Iran. However, based on PCR detection and sequencing of parasite Cysteine Protease B (CPB), only one out of seven sandfly infections in Phlebotomus perfiliewi transcaucasicus was found to be L. infantum in the current investigation. The six other infections were haplotypes of Leishmania donovani, the causative agent of anthroponotic visceral leishmaniasis (AVL) in West Africa and India. The deduced amino acid of the L. donovani haplotype was found to be novel and the shortest CPB protein reported within the Leishmania spp. Circulation of both L. donovani and L. infantum by P. perfiliewi transcaucasicus, in addition to previous data indicating its ability to circulate L. tropica, suggests that this species, like other vectors of VL, is a permissive vector. Finding L. donovani infecting P. perfiliewi transcaucasicus in the area demands extensive and intensive typing of natural Leishmania infections in epidemiological investigations in Iran and the Mediterranean Basin in general. SN - 1090-2449 UR - https://www.unboundmedicine.com/medline/citation/19631209/Phlebotomus_perfiliewi_transcaucasicus_is_circulating_both_Leishmania_donovani_and_L__infantum_in_northwest_Iran_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4894(09)00187-8 DB - PRIME DP - Unbound Medicine ER -