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Novel cyromazine imprinted polymer applied to the solid-phase extraction of melamine from feed and milk samples.
J Chromatogr A. 2009 Aug 21; 1216(34):6196-203.JC

Abstract

A water compatible molecularly imprinted polymer (MIP) using cyromazine as a mimic template, methacrylic acid as the functional polymer and ethylene glycol dimethacrylate as the cross-linker was synthesized and used to extract melamine from feed and milk samples via a molecularly imprinted solid-phase extraction (MISPE) protocol. Optimum retention of melamine on the MISPE cartridge was achieved using methanol, and the interferences in the samples were effectively washed out. The binding capacity of the polymer toward melamine was found to be about 500 microg of melamine/g of polymer. The recoveries of 2 microg and 20 microg melamine standard spiked into water extract of blank feeds and milk samples were between 83.4% and 103%, with relative standard deviation <5.6%. The cyromazine-MIP demonstrated high cross-reactivity for melamine and low affinity to cyanuric acid. The ionic bond interaction was regarded as the main factors that dominated the retention of the melamine on the MISPE cartridge.

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Authors+Show Affiliations

He L
Department of Pharmacology and Toxicology, College of Veterinary Medicine, South China Agriculture University, Guangzhou 510642, China.
Su Y
No affiliation info available
Zheng Y
No affiliation info available
Huang X
No affiliation info available
Wu L
No affiliation info available
Liu Y
No affiliation info available
Zeng Z
No affiliation info available
Chen Z
No affiliation info available

MeSH

Analytic Sample Preparation MethodsAnimal FeedAnimalsCattleFood ContaminationGas Chromatography-Mass SpectrometryMilkMolecular ImprintingPolymersResins, SyntheticSolid Phase ExtractionSolventsTriazines

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19631323

Citation

He, Limin, et al. "Novel Cyromazine Imprinted Polymer Applied to the Solid-phase Extraction of Melamine From Feed and Milk Samples." Journal of Chromatography. A, vol. 1216, no. 34, 2009, pp. 6196-203.
He L, Su Y, Zheng Y, et al. Novel cyromazine imprinted polymer applied to the solid-phase extraction of melamine from feed and milk samples. J Chromatogr A. 2009;1216(34):6196-203.
He, L., Su, Y., Zheng, Y., Huang, X., Wu, L., Liu, Y., Zeng, Z., & Chen, Z. (2009). Novel cyromazine imprinted polymer applied to the solid-phase extraction of melamine from feed and milk samples. Journal of Chromatography. A, 1216(34), 6196-203. https://doi.org/10.1016/j.chroma.2009.06.081
He L, et al. Novel Cyromazine Imprinted Polymer Applied to the Solid-phase Extraction of Melamine From Feed and Milk Samples. J Chromatogr A. 2009 Aug 21;1216(34):6196-203. PubMed PMID: 19631323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel cyromazine imprinted polymer applied to the solid-phase extraction of melamine from feed and milk samples. AU - He,Limin, AU - Su,Yijuan, AU - Zheng,Yaqiu, AU - Huang,Xianhui, AU - Wu,Li, AU - Liu,Yahong, AU - Zeng,Zhenling, AU - Chen,Zhangliu, Y1 - 2009/07/05/ PY - 2009/01/05/received PY - 2009/06/25/revised PY - 2009/06/30/accepted PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2009/10/27/medline SP - 6196 EP - 203 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1216 IS - 34 N2 - A water compatible molecularly imprinted polymer (MIP) using cyromazine as a mimic template, methacrylic acid as the functional polymer and ethylene glycol dimethacrylate as the cross-linker was synthesized and used to extract melamine from feed and milk samples via a molecularly imprinted solid-phase extraction (MISPE) protocol. Optimum retention of melamine on the MISPE cartridge was achieved using methanol, and the interferences in the samples were effectively washed out. The binding capacity of the polymer toward melamine was found to be about 500 microg of melamine/g of polymer. The recoveries of 2 microg and 20 microg melamine standard spiked into water extract of blank feeds and milk samples were between 83.4% and 103%, with relative standard deviation <5.6%. The cyromazine-MIP demonstrated high cross-reactivity for melamine and low affinity to cyanuric acid. The ionic bond interaction was regarded as the main factors that dominated the retention of the melamine on the MISPE cartridge. SN - 1873-3778 UR - https://www.unboundmedicine.com/medline/citation/19631323/Novel_cyromazine_imprinted_polymer_applied_to_the_solid_phase_extraction_of_melamine_from_feed_and_milk_samples_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(09)01011-5 DB - PRIME DP - Unbound Medicine ER -