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Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice.
Brain Res. 2009 Dec 11; 1302:256-64.BR

Abstract

IL-1beta is a potent pro-inflammatory cytokine that regulates neuroinflammation during brain damage. The expression of IL-1beta has been reported to be elevated in the striatum and substantia nigra of patients with Parkinson's disease (PD). Moreover, greater prevalence of PD in men than in women is described previously. Here, by using a sensitive mice model in which the expression of luciferase reporter gene is under the control of human IL-1beta gene promoter, we examined IL-1beta gene expression pattern in vivo after subacute MPTP toxication in old male and female mice and found that MPTP elicited greater dopaminergic toxicity in old male than in female mice. Old male mice showed dramatically elevated luciferase signals in a flexuous manner at early period of time, meanwhile, the changes in female were more moderate. However, no significant difference in astroglial reaction was observed at later time point between sexes. In conclusion, the present study demonstrated that elevated IL-1beta gene expression at early period of time may be in part responsible for the DA neuron susceptibility to MPTP in old male mice.

Authors+Show Affiliations

State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19631617

Citation

Bian, Min-Juan, et al. "Elevated Interleukin-1beta Induced By 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Aggravating Dopaminergic Neurodegeneration in Old Male Mice." Brain Research, vol. 1302, 2009, pp. 256-64.
Bian MJ, Li LM, Yu M, et al. Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice. Brain Res. 2009;1302:256-64.
Bian, M. J., Li, L. M., Yu, M., Fei, J., & Huang, F. (2009). Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice. Brain Research, 1302, 256-64. https://doi.org/10.1016/j.brainres.2009.07.030
Bian MJ, et al. Elevated Interleukin-1beta Induced By 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Aggravating Dopaminergic Neurodegeneration in Old Male Mice. Brain Res. 2009 Dec 11;1302:256-64. PubMed PMID: 19631617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice. AU - Bian,Min-Juan, AU - Li,Li-Mei, AU - Yu,Mei, AU - Fei,Jian, AU - Huang,Fang, Y1 - 2009/07/23/ PY - 2009/03/14/received PY - 2009/07/10/revised PY - 2009/07/14/accepted PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2010/2/24/medline SP - 256 EP - 64 JF - Brain research JO - Brain Res VL - 1302 N2 - IL-1beta is a potent pro-inflammatory cytokine that regulates neuroinflammation during brain damage. The expression of IL-1beta has been reported to be elevated in the striatum and substantia nigra of patients with Parkinson's disease (PD). Moreover, greater prevalence of PD in men than in women is described previously. Here, by using a sensitive mice model in which the expression of luciferase reporter gene is under the control of human IL-1beta gene promoter, we examined IL-1beta gene expression pattern in vivo after subacute MPTP toxication in old male and female mice and found that MPTP elicited greater dopaminergic toxicity in old male than in female mice. Old male mice showed dramatically elevated luciferase signals in a flexuous manner at early period of time, meanwhile, the changes in female were more moderate. However, no significant difference in astroglial reaction was observed at later time point between sexes. In conclusion, the present study demonstrated that elevated IL-1beta gene expression at early period of time may be in part responsible for the DA neuron susceptibility to MPTP in old male mice. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/19631617/Elevated_interleukin_1beta_induced_by_1_methyl_4_phenyl_1236_tetrahydropyridine_aggravating_dopaminergic_neurodegeneration_in_old_male_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)01435-8 DB - PRIME DP - Unbound Medicine ER -