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Primary radiation therapy in patients with localized orbital marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT Lymphoma).
Int J Radiat Oncol Biol Phys 2010; 77(1):86-91IJ

Abstract

PURPOSE

To evaluate the outcomes of patients with localized orbital marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) who were treated with radiotherapy (RT).

METHODS AND MATERIALS

We retrospectively reviewed the records of 46 patients who were treated with RT for pathologically confirmed localized stage IE marginal zone B-cell lymphoma of MALT. The radiation dose ranged from 21.6 to 45 Gy (median, 30.6 Gy) at 1.8-2.0 Gy per fraction. Median follow-up duration was 32.3 months (range, 3.1-113.6 months).

RESULTS

Forty-three patients (93%) achieved complete remission (CR), and three patients (7%) achieved partial remission (PR). Five-year relapse-free survival, cause-specific survival, and overall survival were 93%, 100%, and 100%, respectively. Among the patients with CR, two had recurrence at three sites. One patient relapsed locally and was successfully salvaged with reirradiation. The other patient relapsed in a distant site and was successfully treated with six cycles of CHOP chemotherapy. Late complications were noted in four patients. Two patients developed cataracts at 26 and 37 months after completion of RT. The other two patients developed nasolacrimal duct obstructions at 4 and 11 months after completion of RT.

CONCLUSION

Our study showed that a modest dose of RT is an excellent treatment modality with low complication and recurrence rates. We suggest that a dose of 30.6 Gy is tolerable and sufficient for treating orbital MALT lymphoma. Even following recurrence, successful salvage is possible with RT or chemotherapy.

Authors+Show Affiliations

Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19632068

Citation

Son, Seok Hyun, et al. "Primary Radiation Therapy in Patients With Localized Orbital Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue (MALT Lymphoma)." International Journal of Radiation Oncology, Biology, Physics, vol. 77, no. 1, 2010, pp. 86-91.
Son SH, Choi BO, Kim GW, et al. Primary radiation therapy in patients with localized orbital marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT Lymphoma). Int J Radiat Oncol Biol Phys. 2010;77(1):86-91.
Son, S. H., Choi, B. O., Kim, G. W., Yang, S. W., Hong, Y. S., Choi, I. B., & Kim, Y. S. (2010). Primary radiation therapy in patients with localized orbital marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT Lymphoma). International Journal of Radiation Oncology, Biology, Physics, 77(1), pp. 86-91. doi:10.1016/j.ijrobp.2009.04.018.
Son SH, et al. Primary Radiation Therapy in Patients With Localized Orbital Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue (MALT Lymphoma). Int J Radiat Oncol Biol Phys. 2010 May 1;77(1):86-91. PubMed PMID: 19632068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary radiation therapy in patients with localized orbital marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT Lymphoma). AU - Son,Seok Hyun, AU - Choi,Byung Ock, AU - Kim,Gi Won, AU - Yang,Suk Woo, AU - Hong,Young Seon, AU - Choi,Ihl Bohng, AU - Kim,Yeon Sil, Y1 - 2009/07/23/ PY - 2008/11/26/received PY - 2009/04/15/revised PY - 2009/04/15/accepted PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2010/4/29/medline SP - 86 EP - 91 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 77 IS - 1 N2 - PURPOSE: To evaluate the outcomes of patients with localized orbital marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) who were treated with radiotherapy (RT). METHODS AND MATERIALS: We retrospectively reviewed the records of 46 patients who were treated with RT for pathologically confirmed localized stage IE marginal zone B-cell lymphoma of MALT. The radiation dose ranged from 21.6 to 45 Gy (median, 30.6 Gy) at 1.8-2.0 Gy per fraction. Median follow-up duration was 32.3 months (range, 3.1-113.6 months). RESULTS: Forty-three patients (93%) achieved complete remission (CR), and three patients (7%) achieved partial remission (PR). Five-year relapse-free survival, cause-specific survival, and overall survival were 93%, 100%, and 100%, respectively. Among the patients with CR, two had recurrence at three sites. One patient relapsed locally and was successfully salvaged with reirradiation. The other patient relapsed in a distant site and was successfully treated with six cycles of CHOP chemotherapy. Late complications were noted in four patients. Two patients developed cataracts at 26 and 37 months after completion of RT. The other two patients developed nasolacrimal duct obstructions at 4 and 11 months after completion of RT. CONCLUSION: Our study showed that a modest dose of RT is an excellent treatment modality with low complication and recurrence rates. We suggest that a dose of 30.6 Gy is tolerable and sufficient for treating orbital MALT lymphoma. Even following recurrence, successful salvage is possible with RT or chemotherapy. SN - 1879-355X UR - https://www.unboundmedicine.com/medline/citation/19632068/Primary_radiation_therapy_in_patients_with_localized_orbital_marginal_zone_B_cell_lymphoma_of_mucosa_associated_lymphoid_tissue__MALT_Lymphoma__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(09)00583-5 DB - PRIME DP - Unbound Medicine ER -