Tags

Type your tag names separated by a space and hit enter

Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis.
Biochem Biophys Res Commun. 2009 Oct 09; 388(1):31-4.BB

Abstract

The aim of this study was to investigate the relationship between anti-fibrotic effect of Panax notoginseng saponins (PNS) and serum cytokines in rat hepatic fibrosis. Hepatic fibrosis induced by carbon tetrachloride (CCl(4)) was studied in animal models using SD rats. Liver index, serum alanine amino transferase (ALT), aspartate amino transferase (AST), transforming growth factor-beta1 (TGF-beta1), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured, respectively. Liver index and the degree of liver fibrosis were also determined. Our results showed that the levels of ALT, AST and liver index in PNS-treated group were markedly lower than those in model group. PNS therapy also significantly attenuated the degree of hepatic fibrosis, collagen area and collagen area percent in liver tissue. Furthermore, the levels of serum TGF-beta1, TNF-alpha and IL-6 were strikingly reduced in PNS-treated group compared with model group while the production of IL-10 was up-regulated. These findings demonstrate that PNS has certain therapeutic effects on hepatic fibrosis probably by immunoregulating the imbalance between pro-fibrotic and anti-fibrotic cytokines.

Authors+Show Affiliations

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19632202

Citation

Peng, Xiao-dong, et al. "Relationship Between Anti-fibrotic Effect of Panax Notoginseng Saponins and Serum Cytokines in Rat Hepatic Fibrosis." Biochemical and Biophysical Research Communications, vol. 388, no. 1, 2009, pp. 31-4.
Peng XD, Dai LL, Huang CQ, et al. Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis. Biochem Biophys Res Commun. 2009;388(1):31-4.
Peng, X. D., Dai, L. L., Huang, C. Q., He, C. M., Yang, B., & Chen, L. J. (2009). Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis. Biochemical and Biophysical Research Communications, 388(1), 31-4. https://doi.org/10.1016/j.bbrc.2009.07.099
Peng XD, et al. Relationship Between Anti-fibrotic Effect of Panax Notoginseng Saponins and Serum Cytokines in Rat Hepatic Fibrosis. Biochem Biophys Res Commun. 2009 Oct 9;388(1):31-4. PubMed PMID: 19632202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis. AU - Peng,Xiao-dong, AU - Dai,Li-li, AU - Huang,Chang-quan, AU - He,Chun-mei, AU - Yang,Bing, AU - Chen,Li-juan, Y1 - 2009/07/24/ PY - 2009/07/16/received PY - 2009/07/21/accepted PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2009/9/22/medline SP - 31 EP - 4 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 388 IS - 1 N2 - The aim of this study was to investigate the relationship between anti-fibrotic effect of Panax notoginseng saponins (PNS) and serum cytokines in rat hepatic fibrosis. Hepatic fibrosis induced by carbon tetrachloride (CCl(4)) was studied in animal models using SD rats. Liver index, serum alanine amino transferase (ALT), aspartate amino transferase (AST), transforming growth factor-beta1 (TGF-beta1), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured, respectively. Liver index and the degree of liver fibrosis were also determined. Our results showed that the levels of ALT, AST and liver index in PNS-treated group were markedly lower than those in model group. PNS therapy also significantly attenuated the degree of hepatic fibrosis, collagen area and collagen area percent in liver tissue. Furthermore, the levels of serum TGF-beta1, TNF-alpha and IL-6 were strikingly reduced in PNS-treated group compared with model group while the production of IL-10 was up-regulated. These findings demonstrate that PNS has certain therapeutic effects on hepatic fibrosis probably by immunoregulating the imbalance between pro-fibrotic and anti-fibrotic cytokines. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/19632202/Relationship_between_anti_fibrotic_effect_of_Panax_notoginseng_saponins_and_serum_cytokines_in_rat_hepatic_fibrosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(09)01459-4 DB - PRIME DP - Unbound Medicine ER -