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Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13; 33(8):1417-24.PN

Abstract

Ginseng total saponins (GTS) are the major active components of Panax ginseng C.A. Meyer, which has been used as a popular tonic herb for 2000 years in Far East countries. In the present study, two classic animal models: the forced swimming test (FST) and the chronic mild stress (CMS) model were used to evaluate the antidepressant-like activities of GTS. It was observed that GTS at doses of 50 and 100 mg/kg significantly reduced the immobility time in the FST in mice after 7-day treatment. GTS also reversed the reduction in the sucrose preference index, decrease in locomotor activity as well as prolongation of latency of feeding in the novelty environment displayed by CMS rats. In addition, HPLC-ECD and immunohistochemical staining analysis indicated that the CMS-induced decrease in monoamine neurotransmitter concentration and brain-derived neurotrophic factor (BDNF) expression in the hippocampus were almost completely reversed by GTS. In conclusion, GTS exerts antidepressant-like effects in two highly specific and predictive animal models of depression. The activity of GTS in antidepression may be mediated partly through enhancing the monoamine neurotransmitter concentration and BDNF expression in the hippocampus.

Authors+Show Affiliations

Research Center of Pharmacology and Toxicology, Peking Union Medical College, Institute of Medicinal Plant Development, Beijing, 100193, PR China. danghaixia@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19632285

Citation

Dang, Haixia, et al. "Antidepressant Effects of Ginseng Total Saponins in the Forced Swimming Test and Chronic Mild Stress Models of Depression." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 33, no. 8, 2009, pp. 1417-24.
Dang H, Chen Y, Liu X, et al. Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(8):1417-24.
Dang, H., Chen, Y., Liu, X., Wang, Q., Wang, L., Jia, W., & Wang, Y. (2009). Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. Progress in Neuro-psychopharmacology & Biological Psychiatry, 33(8), 1417-24. https://doi.org/10.1016/j.pnpbp.2009.07.020
Dang H, et al. Antidepressant Effects of Ginseng Total Saponins in the Forced Swimming Test and Chronic Mild Stress Models of Depression. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1417-24. PubMed PMID: 19632285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. AU - Dang,Haixia, AU - Chen,Ying, AU - Liu,Xinmin, AU - Wang,Qiong, AU - Wang,Liwei, AU - Jia,William, AU - Wang,Yuqing, Y1 - 2009/07/24/ PY - 2009/01/10/received PY - 2009/07/14/revised PY - 2009/07/17/accepted PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2010/1/26/medline SP - 1417 EP - 24 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 33 IS - 8 N2 - Ginseng total saponins (GTS) are the major active components of Panax ginseng C.A. Meyer, which has been used as a popular tonic herb for 2000 years in Far East countries. In the present study, two classic animal models: the forced swimming test (FST) and the chronic mild stress (CMS) model were used to evaluate the antidepressant-like activities of GTS. It was observed that GTS at doses of 50 and 100 mg/kg significantly reduced the immobility time in the FST in mice after 7-day treatment. GTS also reversed the reduction in the sucrose preference index, decrease in locomotor activity as well as prolongation of latency of feeding in the novelty environment displayed by CMS rats. In addition, HPLC-ECD and immunohistochemical staining analysis indicated that the CMS-induced decrease in monoamine neurotransmitter concentration and brain-derived neurotrophic factor (BDNF) expression in the hippocampus were almost completely reversed by GTS. In conclusion, GTS exerts antidepressant-like effects in two highly specific and predictive animal models of depression. The activity of GTS in antidepression may be mediated partly through enhancing the monoamine neurotransmitter concentration and BDNF expression in the hippocampus. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/19632285/Antidepressant_effects_of_ginseng_total_saponins_in_the_forced_swimming_test_and_chronic_mild_stress_models_of_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(09)00248-6 DB - PRIME DP - Unbound Medicine ER -