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[Vitamin D supplementation in institutionalized elderly. Effects of vitamin D3 (100,000 IU) orally administered every 3 months on serum levels of 25-hydroxyvitamin D].
Rev Rhum Mal Osteoartic 1990; 57(11):809-13RR

Abstract

A clinical trial carried out during the autumn/winter season in 46 institutionalized elderly subjects (35 women, 11 men) (group mean age = 83 +/- 2 years) revealed a severe deficiency in vitamin D in these subjects (25-hydroxyvitamin D level less than or equal to 3 ng/ml). After oral administration of 100,000 IU of vitamin D3, an increase in 25-hydroxyvitamin D levels above the 10 ng/ml threshold was observed and maintained for three months. A second dose, administered after 3 months, made it possible to sustain this level. No sign of toxicity was detected, notably no trace of hypercalcemia. In contrast, no change in the deficit (25-hydroxyvitamin D level less than or equal to 3 ng/ml) was seen in the placebo population. Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures.

Authors+Show Affiliations

C.N.R.S. URA 583, Université Paris V, Hôpital Necker, Paris.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

fre

PubMed ID

1963239

Citation

Zeghoud, F, et al. "[Vitamin D Supplementation in Institutionalized Elderly. Effects of Vitamin D3 (100,000 IU) Orally Administered Every 3 Months On Serum Levels of 25-hydroxyvitamin D]." Revue Du Rhumatisme Et Des Maladies Osteo-articulaires, vol. 57, no. 11, 1990, pp. 809-13.
Zeghoud F, Jardel A, Garabedian M, et al. [Vitamin D supplementation in institutionalized elderly. Effects of vitamin D3 (100,000 IU) orally administered every 3 months on serum levels of 25-hydroxyvitamin D]. Rev Rhum Mal Osteoartic. 1990;57(11):809-13.
Zeghoud, F., Jardel, A., Garabedian, M., Salvatore, R., & Moulias, R. (1990). [Vitamin D supplementation in institutionalized elderly. Effects of vitamin D3 (100,000 IU) orally administered every 3 months on serum levels of 25-hydroxyvitamin D]. Revue Du Rhumatisme Et Des Maladies Osteo-articulaires, 57(11), pp. 809-13.
Zeghoud F, et al. [Vitamin D Supplementation in Institutionalized Elderly. Effects of Vitamin D3 (100,000 IU) Orally Administered Every 3 Months On Serum Levels of 25-hydroxyvitamin D]. Rev Rhum Mal Osteoartic. 1990;57(11):809-13. PubMed PMID: 1963239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Vitamin D supplementation in institutionalized elderly. Effects of vitamin D3 (100,000 IU) orally administered every 3 months on serum levels of 25-hydroxyvitamin D]. AU - Zeghoud,F, AU - Jardel,A, AU - Garabedian,M, AU - Salvatore,R, AU - Moulias,R, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 809 EP - 13 JF - Revue du rhumatisme et des maladies osteo-articulaires JO - Rev Rhum Mal Osteoartic VL - 57 IS - 11 N2 - A clinical trial carried out during the autumn/winter season in 46 institutionalized elderly subjects (35 women, 11 men) (group mean age = 83 +/- 2 years) revealed a severe deficiency in vitamin D in these subjects (25-hydroxyvitamin D level less than or equal to 3 ng/ml). After oral administration of 100,000 IU of vitamin D3, an increase in 25-hydroxyvitamin D levels above the 10 ng/ml threshold was observed and maintained for three months. A second dose, administered after 3 months, made it possible to sustain this level. No sign of toxicity was detected, notably no trace of hypercalcemia. In contrast, no change in the deficit (25-hydroxyvitamin D level less than or equal to 3 ng/ml) was seen in the placebo population. Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures. SN - 0035-2659 UR - https://www.unboundmedicine.com/medline/citation/1963239/[Vitamin_D_supplementation_in_institutionalized_elderly__Effects_of_vitamin_D3__100000_IU__orally_administered_every_3_months_on_serum_levels_of_25_hydroxyvitamin_D]_ L2 - https://medlineplus.gov/vitaminddeficiency.html DB - PRIME DP - Unbound Medicine ER -