Tags

Type your tag names separated by a space and hit enter

Ion channel and receptor mechanisms of bladder afferent nerve sensitivity.
Auton Neurosci. 2010 Feb 16; 153(1-2):26-32.AN

Abstract

Sensory nerves of the urinary bladder consist of small diameter A(delta) and C fibers running in the hypogastic and pelvic nerves. Neuroanatomical studies have revealed a complex neuronal network within the bladder wall. Electrophysiological recordings in vitro and in vivo have revealed several distinct classes of afferent fibers that may signal a wide range of bladder stimulations including physiological bladder filling, noxious distension, cold, chemical irritation and inflammation. The exact mechanisms that underline mechanosensory transduction in bladder afferent terminals remain ambiguous; however, a wide range of ion channels (e.g., TTX-resistant Na(+) channels, Kv channels and hyperpolarization-activated cyclic nucleotide-gated cation channels) and receptors (e.g., TRPV1, TRPM8, TRPA1, P2X(2/3), etc) have been identified at bladder afferent terminals and implicated in the generation and modulation of afferent signals. Experimental investigations have revealed that expression and/or function of these ion channels and receptors may be altered in animal models and patients with overactive and painful bladder disorders. Some of these ion channels and receptors may be potential therapeutic targets for bladder diseases.

Authors+Show Affiliations

Department of Physiology, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19632906

Citation

Sun, Biying, et al. "Ion Channel and Receptor Mechanisms of Bladder Afferent Nerve Sensitivity." Autonomic Neuroscience : Basic & Clinical, vol. 153, no. 1-2, 2010, pp. 26-32.
Sun B, Li Q, Dong L, et al. Ion channel and receptor mechanisms of bladder afferent nerve sensitivity. Auton Neurosci. 2010;153(1-2):26-32.
Sun, B., Li, Q., Dong, L., & Rong, W. (2010). Ion channel and receptor mechanisms of bladder afferent nerve sensitivity. Autonomic Neuroscience : Basic & Clinical, 153(1-2), 26-32. https://doi.org/10.1016/j.autneu.2009.07.003
Sun B, et al. Ion Channel and Receptor Mechanisms of Bladder Afferent Nerve Sensitivity. Auton Neurosci. 2010 Feb 16;153(1-2):26-32. PubMed PMID: 19632906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ion channel and receptor mechanisms of bladder afferent nerve sensitivity. AU - Sun,Biying, AU - Li,Qian, AU - Dong,Li, AU - Rong,Weifang, Y1 - 2009/07/25/ PY - 2009/04/04/received PY - 2009/07/06/revised PY - 2009/07/06/accepted PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2010/4/17/medline SP - 26 EP - 32 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 153 IS - 1-2 N2 - Sensory nerves of the urinary bladder consist of small diameter A(delta) and C fibers running in the hypogastic and pelvic nerves. Neuroanatomical studies have revealed a complex neuronal network within the bladder wall. Electrophysiological recordings in vitro and in vivo have revealed several distinct classes of afferent fibers that may signal a wide range of bladder stimulations including physiological bladder filling, noxious distension, cold, chemical irritation and inflammation. The exact mechanisms that underline mechanosensory transduction in bladder afferent terminals remain ambiguous; however, a wide range of ion channels (e.g., TTX-resistant Na(+) channels, Kv channels and hyperpolarization-activated cyclic nucleotide-gated cation channels) and receptors (e.g., TRPV1, TRPM8, TRPA1, P2X(2/3), etc) have been identified at bladder afferent terminals and implicated in the generation and modulation of afferent signals. Experimental investigations have revealed that expression and/or function of these ion channels and receptors may be altered in animal models and patients with overactive and painful bladder disorders. Some of these ion channels and receptors may be potential therapeutic targets for bladder diseases. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/19632906/Ion_channel_and_receptor_mechanisms_of_bladder_afferent_nerve_sensitivity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(09)00405-6 DB - PRIME DP - Unbound Medicine ER -